医学研究与教育 ›› 2023, Vol. 40 ›› Issue (5): 1-7.DOI: 10.3969/j.issn.1674-490X.2023.05.001

• 磁共振成像专题 •    下一篇

磁共振成像增强肝胆期不同病理分级肝内肿块型胆管癌的信号特征分析

殷小平,邢立红,卓利勇,张宇,王佳宁,刘珊,陈新星   

  1. 河北大学附属医院放射科, 河北 保定 071000)殷小平, 博士, 教授, 主任医师, 河北大学附属医院副院长、护理学院副院长, 河北省炎症相关肿瘤精准影像学重点实验室主任, 河北省放射影像科医学重点学科的学科带头人, 河北省“三三三人才工程”第二层次人选, 保定优管专家。现任中国研究型医院感染与炎症放射学组青年学组主任委员, 中华放射学会传染学组委员, 中国抗癌协会影像专委会委员, 北京影像诊疗创新联盟青年委员主任委员, 中国医学救援协会影像分会委员, 河北省放射学会常委, 河北省女医师学会影像学分会副主任委员, 河北省神经学影像分会常委, 保定市放射学会主任委员。主要从事腹盆腔系统疾病的影像研究, 尤其侧重影像组学及人工智能在肿瘤精准影像诊断及预后评估的研究。承担省科技厅、卫生厅、财政厅等项目17项, 以第一作者或通信作者发表SCI文章26篇, SCI总影响因子=134.7, 其中高被引1篇(被引次数208), JCR 1区2篇, JCR 2区12篇, 核心期刊50余篇。获得河北省科技进步一等奖1项, 二等奖1项, 三等奖1项, 市厅级科技奖一等奖3项。参编著作9部, 牵头起草并发布河北省地方标准《新型冠状病毒感染疫情期间放射学科防控技术要求》一部, 参与专利发明2项。
  • 收稿日期:2023-03-08 出版日期:2023-10-25 发布日期:2023-10-26
  • 作者简介:殷小平(1978—), 女, 河北徐水人, 主任医师,教授,博士,博士生导师,主要从事腹盆腔疾病的影像诊断研究。 E-mail: hdfyrad@hbu.edu.cn
  • 基金资助:
    河北省“三三三人才工程”项目(B20031008);保定市科学技术研究与发展计划项目(2041ZF176)

  • Received:2023-03-08 Online:2023-10-25 Published:2023-10-26

摘要: 目的 探讨MRI增强肝胆期信号特征与肝内肿块型胆管癌(intrahepatic mass cholangiocarcinoma, IMCC)病理分级的关系。方法 回顾性分析IMCC确诊患者,分析病灶肝胆期的信号特征。统计学分析采用卡方检验。结果 IMCC确诊患者共49例,高分化5例,中分化26例,低分化18例。病灶长径<3 cm者11例,3~6 cm者18例,>6 cm者20例。肝胆期出现靶征者21例,多层靶征20例,低信号8例。肝胆期病灶外周低信号环存在41例,其中环完整20例,不完整21例。病灶大小在不同肝胆期信号间、低信号环是否完整在不同病理间的差异有统计学意义(χ2=18.937,P=0.001;χ2=6.618,P=0.037)。结论 肝胆期病灶外周低信号环不完整多见于低分化IMCC,病灶越大者越多呈分层靶征。

关键词: 磁共振成像, 肿块型胆管癌, 肝胆期, 病理分级

Abstract: Objective To investigate the relationship between signal characteristics in enhanced-MRI hepatobiliary phase(HBP)and pathological grade of intrahepatic mass cholangiocarcinoma(IMCC). Methods Patients diagnosed with IMCC were retrospectively analyzed, and the signal characteristics of lesions in HBP were analyzed. Statistical analysis was performed by Chi-square test. Results 49 patients were diagnosed with IMCC. There were 5 cases with well-differentiated, 26 cases with moderately-differentiated and 18 cases with poorly-differentiated. 11 patients with lesion length less than 3 cm; 18 patients with lesion length between 3 cm and 6 cm, 20 patients with lesion length more than 6 cm. In HBP, 21 patients had target sign, 20 patients had multilayer target sign, and 8 patients had low signal. 41 cases had peripheral low. The difference of lesion size between different signal in HBP, and the difference of peripheral low signal ring integrity between different pathological grades were statistically significant(χ2=18.937, P=0.001; χ2=6.618, P=0.037). Conclusion Incomplete peripheral low signal ring in HBP is more common in poorly-differentiated IMCC, and the larger the lesion is, the more it shows multilayer target sign.

Key words: magnetic resonance imaging, intrahepatic mass-forming cholangiocarcinoma, hepatobiliary phase, pathological grade

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