医学研究与教育 ›› 2012, Vol. 29 ›› Issue (6): 47-54.
陈玉敏1,陈涛平2,冯浩楼1
收稿日期:
2016-10-09
修回日期:
2016-10-09
出版日期:
2012-12-25
发布日期:
2012-12-25
Received:
2016-10-09
Revised:
2016-10-09
Online:
2012-12-25
Published:
2012-12-25
摘要: 脑缺血再灌注损伤是一种复杂的病理生理过程,这个级联反应包括多种因素多种环节相互作用、共同参与.现就脑缺血再灌注损伤的机制和治疗做一综述.
中图分类号:
陈玉敏,陈涛平,冯浩楼. 脑缺血再灌注损伤机制与治疗现状[J]. 医学研究与教育, 2012, 29(6): 47-54.
[1] 甘照儒, 桑栎楠, GAN Zhao-ru, SANG Li-nan. 脑缺血/再灌注损伤级联反应研究进展 [J]. 医学综述 2009.doi:10.3969/j.issn.1006-2084.2009.01.015 [2] 陈莎, 姚辉, 艾洪武, 游上游, CHEN Sha, YAO Hui, AI Hongwu, YOU Shangyou. 足月新生儿缺氧缺血性脑病患儿脑脊液Na+、游离Ca2+含量的分析 [J]. 检验医学 2005.doi:10.3969/j.issn.1673-8640.2005.03.019 [3] 邓银侠, 高俊玲. 脑缺血再灌注后细胞凋亡基因的研究进展 [J]. 中国现代医药杂志 2009.doi:10.3969/j.issn.1672-9463.2009.04.057 [4] 王兴盛, 苗莉, 姚小梅, 朱学良, WANG Xingsheng, MIAO Li, YAO Xiaomei, ZHU Xueliang. 大鼠脑缺血再灌注后血脑屏障超微结构的改变 [J]. 天津医药 2006.doi:10.3969/j.issn.0253-9896.2006.03.016 [5] 罗雅娟. 亚低温治疗对心肺复苏后脑保护作用的研究进展 [J]. 江西医药 2011.doi:10.3969/j.issn.1006-2238.2011.04.048 [6] 张梅, 王伟平. 依达拉奉治疗急性脑梗死的疗效观察与护理 [J]. 中国实用神经疾病杂志 2007.doi:10.3969/j.issn.1673-5110.2007.07.046 [7] 赵永福. 依达拉奉对脑缺血再灌注损伤的保护作用 [J]. 中国实用神经疾病杂志 2012.doi:10.3969/j.issn.1673-5110.2012.09.033 [8] 武变瑛, 李利平, 张新颖, 王艳, 巴卫松, WU Bian-ying, LI Li-ping, ZHANG Xin-ying, WANG Yan, BA Wei-song. 杏花雨对血管性痴呆大鼠行为及其海马Bcl-2, Bax蛋白表达的影响 [J]. 河北大学学报(自然科学版) 2012.doi:10.3969/j.issn.1000-1565.2012.04.009 [9] 汪洋, 李维祖, 尹艳艳, 曹曦, 明亮, 李卫平. 麝香醒脑宁对大鼠全脑缺血/再灌注损伤的保护作用 [J]. 安徽医科大学学报 2009.doi:10.3969/j.issn.1000-1492.2009.04.017 [10] 王希, 武建卓, 宋淑亮, 王允山, 梁浩, 吉爱国, WANG Xi, WU Jian-zhuo, SONG Shu-liang, WANG Yun-shan, LIANG Hao, JI Ai-guo. 水蛭多肽对局灶大鼠脑缺血再灌注损伤保护作用 [J]. 中国生化药物杂志 2010. [11] 张秋玲, 孙远标, 王海英, 宋述杰, 白波, ZHANG Qiu-ling, SUN Yuan-biao, WANG Hai-ying, SONG Shu-jie, BAI Bo. 白花丹参对大鼠脑缺血再灌注致线粒体损伤及细胞凋亡的影响 [J]. 中国病理生理杂志 2010.doi:10.3969/j.issn.1000-4718.2010.04.020 [12] 吴倩佳, 李光来. 乌司他丁对大鼠局灶性脑缺血再灌注损伤caspase-3表达的影响 [J]. 中西医结合心脑血管病杂志 2011.doi:10.3969/j.issn.1672-1349.2011.05.039 [13] 杨涓, 王秋娟, 潘志伟, 朱家壁, YANG Juan, WANG Qiu-juan, PAN Zhi-wei, ZHU Jia-bi. 注射用尼莫地平脂质体对大鼠全脑缺血再灌注和小鼠缺氧性损伤的保护作用 [J]. 中国临床药理学与治疗学 2006.doi:10.3969/j.issn.1009-2501.2006.12.019 [14] 关莉, 闫福曼, 张哓东, 苏文, 李小英, 周乐全, 罗荣敬, GUAN Li, YAN Fu-man, HANG Xiao-dong, SU Wen, LI Xiao-ying, ZHOU Le-quan, LUO Rong-jing. 补阳还五汤对全脑缺血模型大鼠再灌注不同时点皮质神经细胞钙超载的影响 [J]. 安徽中医学院学报 2008.doi:10.3969/j.issn.1000-2219.2008.04.022 [15] 李亮, 陈立峰. 中药对脑缺血再灌注损伤保护作用的研究进展 [J]. 中南药学 2012.doi:10.3969/j.issn.1672-2981.2012.06.019 [16] 汪茜, 王明新, 王洁, 夏红杰, 马立芝, WANG Qian, WANG Ming-xin, WANG Jie, XIA Hong-jie, MA Li-zhi. 黄芪多糖对缺血缺氧脑损伤大鼠脑组织Ca2+和兴奋性氨基酸的影响 [J]. 中国新药杂志 2006.doi:10.3321/j.issn:1003-3734.2006.12.011 [17] 李浩, 刘开祥, 俸军林, LI Hao, LIU Kai-xiang, FENG Jun-lin. 丹参酮ⅡA对鼠脑缺血再灌注损伤一氧化氮及一氧化氮合酶的影响 [J]. 中国康复理论与实践 2008.doi:10.3969/j.issn.1006-9771.2008.05.011 [18] 刘树玲, 刘梅芳, 朱宝亮, LIU Shu-ling, LIU Mei-fang, ZHU Bao-liang. 中草药成分抗缺血性脑卒中药理作用的研究进展 [J]. 医学综述 2009.doi:10.3969/j.issn.1006-2084.2009.22.040 [19] 倪彩霞, 曾南, 汤奇, 许福会, 苟玲, 王建, 夏厚林. 芳香开窍药对脑缺血再灌注损伤小鼠血脑屏障通透性的影响 [J]. 时珍国医国药 2011.doi:10.3969/j.issn.1008-0805.2011.11.029 [20] 赵见文, 田军彪, 张颜伟, 李佃贵, 杨丽静, 刘学飞. 化浊解毒活血通络法对脑缺血再灌注损伤小鼠行为学及海马CA1区神经细胞形态学的影响 [J]. 世界中医药 2011.doi:10.3969/j.issn.1673-7202.2011.06.041 [21] Aito H, Aalto KT, Raivio KO. Biphasic ATP depletion caused by transient oxidative exposure is associated with apoptotic cell death in rat embryonal cortical neurons. [J]. Pediatric Research 2002, 1(1). [22] Jassem Wayel, Fuggle SusanV, Rela Mohamed, Koo-DickenD H, Heaton NigelD. The role of mitochondria in ischemia/reperfusion injury. [J]. Transplantation: Official Journal of the Transplantation Society 2002, 4(4). [23] Zaleska MM, Mercado ML, Chavez J, Feuerstein GZ, Pangalos MN, Wood A. The development of stroke therapeutics: Promising mechanisms and translational challenges. [J]. Neuropharmacology 2009, 2(2). [24] Huang J, Upadhyay UM, Tamargo RJ. Inflammation in stroke and focal cerebral ischemia. [J]. Surgical neurology 2006, 3(3). [25] Ekdahl CT, Kokaia Z, Lindvall O. Brain inflammation and adult neurogenesis: the dual role of microglia. [J]. Neuroscience: An International Journal under the Editorial Direction of IBRO 2009, 3(3). [26] Yan YP, Sailor KA, Lang BT, Park SW, Vemuganti R, Dempsey RJ. Monocyte chemoattractant protein-1 plays a critical role in neuroblast migration after focal cerebral ischemia. [J]. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism 2007, 6(6). [27] 陈胜. 脑缺血再灌注损伤后神经细胞凋亡的研究进展 [J]. 中国新医学论坛 2009. [28] Zhou, X, Fan, GC, Ren, X, Waggoner, JR, Gregory, KN, Chen, G, Jones, WK, Kranias, EG. Overexpression of histidine-rich Ca-binding protein protects against ischemia/reperfusion-induced cardiac injury. [J]. Cardiovascular Research 2007, 3(3). [29] Costa C, Martella G, Picconi B, Prosperetti C, Pisani A, Di Filippo M, Pisani F, Bernardi G, Calabresi P. Multiple mechanisms underlying the neuroprotective effects of antiepileptic drugs against in vitro ischemia. [J]. Stroke: A Journal of Cerebral Circulation 2006, 5(5). [30] FELIX S, JEANNIN S, GOIZET C. Stroke following pulmonary arteriovenous fistula embolization in a patient with HHT [J]. Neurology 2008, 71(24). [31] Mehta SL, Manhas N, Raghubir R. Molecular targets in cerebral ischemia for developing novel therapeutics. [J]. Brain research. Brain research reviews 2007, 1(1). [32] Xing B, Chen H, Zhang M, Zhao D, Jiang R, Liu X, Zhang S. Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat. [J]. Stroke: A Journal of Cerebral Circulation 2008, 8(8). [33] Gao DK, Zhang X, Jiang XF, Peng YB, Huang WD, Cheng G, Song L. Resveratrol reduces the elevated level of MMP-9 induced by cerebral ischemia-reperfusion in mice [J]. Life sciences 2006, 22(22). [34] DING Shinghua, WANG Tiannan, CUI Wenju. Photothrombosis ischemia stimulates a sustained astrocytic Ca2+signaling in vivo [J]. Glia 2009, 57(07). [35] SHEN Jia, ZHOU Jingyi, PENG Yunlong. Ischenmic postconditioning protects against cerebral ischemia/reperfusion-induced calcium overload in mice [J]. Federation of America Societies for Experimental Biology Journal 2009, 23(01). [36] ITO Y, OHKUBO T, ASANO Y. Nitric oxide production during cerebral ischemia and reperfusion in eNOS-and nNOS-knockout mice [J]. Current Neurovascular Research 2010, 7(01). [37] Jiang MH, Kaku T, Hada J, Hayashi Y. Different effects of eNOS and nNOS inhibition on transient forebrain ischemia. [J]. Brain research 2002, 1(1). [38] Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest [J]. New England Journal of Medicine 2002, 346(08). [39] Bernard StephenA, Gray TimothyW, Buist MichaelD, Jones BruceM, Silvester William, Gutteridge Geoff, Smith Karen. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. [J]. The New England journal of medicine 2002, 8(8). [40] International Liaison Committee on Resuscition. 2005 International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations [J]. Resuscitation 2005, 67(02). [41] Field JM, Hazinski MF, Sayre MR, Chameides L, Schexnayder SM, Hemphill R, Samson RA, Kattwinkel J, Berg RA, Bhanji F, Cave DM, Jauch EC, Kudenchuk PJ, Neumar RW, Peberdy MA, Perlman JM, Sinz E, Travers AH, Berg MD, Billi JE, Eigel B, Hickey RW, Kleinman ME, Link MS, Morrison LJ, O'Connor RE, Shuster M, Callaway CW, Cucchiara B, Ferguson JD, Rea TD, Vanden Hoek TL. Part 1: executive summary: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. [J]. Circulation: An Official Journal of the American Heart Association 2010, 18 Suppl.3(18 Suppl.3). [42] Nadareishvili ZG, Li H, Wright V, Maric D, Warach S, Hallenbeck JM, Dambrosia J, Barker JL, Baird AE. Elevated pro-inflammatory CD4+CD28- lymphocytes and stroke recurrence and death. [J]. Neurology: Official Journal of the American Academy of Neurology 2004, 8(8). [43] DANIEL STRBIAN, PETRI T. KOVANEN, MARJA-LIISA KARJALAINEN-LINDSBERG, TURGUT TATLISUMAK, PERTTU J. LINDSBERG. [J]. Annals of medicine 2009. [44] Felger JC, Abe T, Kaunzner UW, Gottfried Blackmore A, Gal Toth J, McEwen BS, Iadecola C, Bulloch K. Brain dendritic cells in ischemic stroke: time course, activation state, and origin. [J]. Brain, Behavior, and Immunity 2010, 5(5). [45] De La Cruz JP, Guerrero A, Gonzalez Correa JA, Arrebola MM, de la Cuesta SF. [J]. Journal of Neuroscience Research 2004. [46] Zieden B, Olsson AG. The role of statins in the prevention of ischemic stroke. [J]. Current atherosclerosis reports 2005, 5(5). [47] Puato M, Faggin E, Rattazzi M, Zambon A, Cipollone F, Grego F, Ganassin L, Plebani M, Mezzetti A, Pauletto P. [J]. Stroke: A Journal of Cerebral Circulation 2010. [48] Tuttolomondo A, Di Sciacca R, Di Raimondo. Inflammation as a therapeutic target in acute ischemic stroke treatment. [J]. Current topics in medicinal chemistry 2009, 14(14). [49] Endo H, Kamada H, Nito C, Nishi T, Chan PH. Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats. [J]. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 2006, 30(30). [50] Niizuma, K, Endo, H, Nito, C, Myer, DJ, Kim, GS, Chan, PH. [J]. Proceedings of the National Academy of Sciences of the United States of America 2008. [51] 韩威, 野向春, 孟昭杰, 魏胜男, 常文光. 尼莫地平对大鼠急性脑缺血再灌注损伤早期保护作用的研究 [J]. 中风与神经疾病杂志 2012. [52] KIEWERT C, HARTMANN J, STOLL J. NGP1-01 is a brain-permeable dual blocker of neuronal voltage-and ligand-operated calcium channels [J]. Neurochemical Research 2006, 31(03). [53] Koinig H, Vornik V, Rueda C, Zornow MH. Lubeluzole inhibits accumulation of extracellular glutamate in the hippocampus during transient global cerebral ischemia. [J]. Brain research 2001, 2(2). [54] Zhang Y, Jin Y, Behr MJ, Feustel PJ, Morrison JP, Kimelberg HK. [J]. Experimental Neurology 2005. [55] O'Neill MJ, Murray TK, McCarty DR, Hicks CA, Dell CP, Patrick KE, Ward MA, Osborne DJ, Wiernicki TR, Roman CR, Lodge D, Fleisch JH, Singh J. [J]. Brain research 2000. [56] GüMüSTAS K, META GüZEYLI F M, ATüKEREN P. The effects of vitmin E on lipid peroxidation, nitric oxide production and superoxide dismutase expression in hyperglycemic rats with cerebral ischemia-reperfusion injury [J]. Turk Neurosurg 2007, 17(02). [57] 王永炎. 中医内科学 [M]. 上海:上海科学技术出版社 1994. [58] Shaltoni HM, Albright KC, Gonzales NR, Weir RU, Khaja AM, Sugg RM, Campbell-MS 3rd, Cacayorin ED, Grotta JC, Noser EA. [J]. Stroke: A Journal of Cerebral Circulation 2007. [59] Shi ZS, Loh Y, Walker G, Duckwiler GR. Endovascular thrombectomy for acute ischemic stroke in failed intravenous tissue plasminogen activator versus non-intravenous tissue plasminogen activator patients: revascularization and outcomes stratified by the site of arterial occlusions. [J]. Stroke: A Journal of Cerebral Circulation 2010, 6(6). |
[1] | 张印恩,于欢欢,王键龙,胡斌,曾诚,林文哲,徐瑞轩,焦建宝. 关于戈勒姆病的研究进展[J]. 医学研究与教育, 2023, 40(5): 29-37. |
[2] | 王密,刘芳,陈菁菁,赵虎. 不同治疗方法在隐裂牙中的回顾性分析[J]. 医学研究与教育, 2023, 40(3): 22-27. |
[3] | 宫哲轩,武广义. 糖皮质激素治疗不同原因急性肺损伤研究进展[J]. 医学研究与教育, 2023, 40(3): 28-37. |
[4] | 范文甜,许亚欣,刘艺珂,陈春红. 急性ST段抬高型心肌梗死患者经皮冠状动脉介入治疗术后无复流现象的治疗进展[J]. 医学研究与教育, 2023, 40(3): 38-45. |
[5] | 张天桥,田艺超,闫玲,田素斋,龚树辉. 不同呼吸训练在腰背痛康复中的应用进展[J]. 医学研究与教育, 2023, 40(3): 61-67. |
[6] | 房翠,王秀丽,李玲钰,史福平. 缺血性脑卒中后抑郁的发病机制及新生物学指标[J]. 医学研究与教育, 2023, 40(2): 18-24. |
[7] | 贾海燕,张卫锋,贾辛未,宋万庆,孙微微,王乾一. 急性心肌梗死不同冠脉介入治疗时机的预后分析[J]. 医学研究与教育, 2023, 40(2): 25-32. |
[8] | 汪晓晨,邴子钰,孔珺. 前体mRNA剪接因子基因突变与视网膜色素变性的研究进展[J]. 医学研究与教育, 2023, 40(1): 10-21. |
[9] | 王艳萌,王宁,隗麒轩,黄雨青,杨信才. 以三甲医院为主导的康复管理体系对脑卒中偏瘫患者的影响[J]. 医学研究与教育, 2023, 40(1): 29-32. |
[10] | 高旗,孙天培,武广义. 老年患者术后谵妄的病理生理机制研究进展[J]. 医学研究与教育, 2022, 39(4): 8-13. |
[11] | 谢瑞娟,邓赟,刘涓,杨楠,张堃. 以感觉刺激为导向的易化技术对脑卒中后上肢功能康复效果的影响[J]. 医学研究与教育, 2022, 39(4): 14-21. |
[12] | 李睿明,段凯旋,崔丹丹,郭宇. 基于岗位标准的康复治疗技术专业课程体系构建[J]. 医学研究与教育, 2022, 39(4): 73-80. |
[13] | 高春婷,袁慧,杜军辉. 双眼视功能异常在近视进展中作用的研究进展[J]. 医学研究与教育, 2022, 39(3): 14-20. |
[14] | 王静,韩力,张泽明. 慢性阻塞性肺疾病相关肺动脉高压的研究进展[J]. 医学研究与教育, 2022, 39(3): 21-28. |
[15] | 郝建章, 张虎. 视网膜静脉阻塞合并黄斑水肿的治疗与展望[J]. 医学研究与教育, 2022, 39(3): 35-40. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||