医学研究与教育 ›› 2015, Vol. 32 ›› Issue (2): 40-43.

• 临床研究 • 上一篇    下一篇

血浆 β2- 微球蛋白、H-CRP、HCY 与外周动脉粥样硬化病的风险分级关系

冀景刚,刘海勇,孙立巍,赵俊卿,顾学昌,左瑞菊,曹丽秋,步玉辉   

  1. 沧州市人民医院,河北 沧州 061000
  • 出版日期:2015-04-25 发布日期:2015-04-25
  • 通讯作者: 步玉辉(1987—),男,河北吴桥人,医师,硕士,主要从事甲状腺、乳腺的临床治疗及基础研究。E-mail: buyuhui1987@126.com
  • 作者简介:冀景刚(1972—),男,河北河间人,主治医师,主要从事周围血管外科治疗。E-mail: jjgczs @163.com

Risk classification of plasma β2-microglobulin, high-CRP, HCY and peripheral atherosclerosis disease

JI Jinggang, LIU Haiyong, SUN Liwei, ZHAO Junqing, GU Xuechang, ZUO Ruiju, CAO Liqiu, BU Yuhui   

  1. Cangzhou People’s Hospital, Cangzhou 061000, China
  • Online:2015-04-25 Published:2015-04-25

摘要: 目的 探讨外周动脉粥样硬化病(PAD)风险分级与血浆 β2- 微球蛋白(β2-microglobulin, β2-MG)、高敏 C 反应蛋白(high-sensitivity C-reactive protein H-CRP)和同型半胱氨酸 (homocysteine,HCY)关系。方法 对沧州市人民医院普外(血管外科)2010 年 1 月至 2013 年 5 月诊治的 PAD 患者 96 例进行分级。按 ABI 值分为:低风险组(0.7≤ABI ≤0.9,n=25),中风险组(0.4≤ABI<0.7, n=52)和高风险组(ABI<0.4, n=19)。均以同期 40 例健康者作为对照,比较各组的β2-MG、H-CRP、HCY 的浓度,进行相关性分析。 结果 血清 β2-MG、H-CRP 、HCY 的浓度随着 ABI 分期的进展而升高,ABI 的数值与 β2-MG、H-CRP、HCY 的浓度呈负相关(P<0.05)。 结论 PAD 随着病情的严重程度,血浆中的β2-MG、H-CRP、HCY 浓度逐渐升高;β2-MG 、H-CRP 和 HCY 联合测定与 ABI 分级结合有助于更好地判断 PAD 患者的诊断和预后。

关键词: 外周动脉粥样硬化病, β2- 微球蛋白, ABI, H-CRP, HCY

Abstract: Objective To investigate the peripheral atherosclerotic disease (PAD) risk classification and plasma β2-microglobulin (β2-microglobulin, β2-MG) high-sensitivity C-reactive protein (H-CRP) of homocysteine (HCY) relationship. Methods From January, 2010 to May, 2013 96 PAD patients were graded and treated in our hospital. According to the ABI value they were divided into: low risk group (0.7≤ABI≤0.9, n=25), medium risk group (0.4≤ABI<0.7, n=52), and the high risk group (ABI<0.4, n=19). 40 healthy persons served as the controls the concentration of β2-microglobulin, high CRP, HCY and their correlation were analyzed. Results The concentration of serumβ2-MG, H-CRP, HCY increased with the ABI stage and the progress, the concentrations were negatively correlated with ABI value with a beta 2-microglobulin H-CRP HCY. Conclusion PAD with the severity of the condition, in the plasma β2-MG H-CRP HCY concentration increased gradually,the joint determination of β2-MG H-CRP HCY and ABI combined with a hierarchical diagnosis and prognosis of patients with PAD is helpful to make sound diagnosis

Key words: peripheral atherosclerotic disease, &beta, 2-microglobulin, ABI, H-CRP, HCY

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