亚临床甲状腺功能减退患者血清促甲状腺激素水平与冠脉病变的相关性

doi:10.3969/j.issn.1674-490X.2020.01.008

医学研究与教育 ›› 2020, Vol. 37 ›› Issue (1): 41-46.DOI: 10.3969/j.issn.1674-490X.2020.01.008

亚临床甲状腺功能减退患者血清促甲状腺激素水平与冠脉病变的相关性

于莹¹,李晓盼¹,付然¹,宋朕¹,王超²

1.承德医学院研究生学院, 河北承德 067000;
2.保定市第一中心医院心脏重症监护室, 河北保定 071000

收稿日期:2019-12-05 出版日期:2020-02-25 发布日期:2020-02-25
通讯作者: 王超(1975—),男,河北保定人,主任医师,教授,硕士生导师,主要从事冠状动脉介入研究。E-mail: we123aaa@aliyun.com
作者简介:于莹(1994—),女,河北廊坊人,医师,在读硕士,主要从事冠心病的诊疗。 E-mail: yuying94@qq.com

Received:2019-12-05 Online:2020-02-25 Published:2020-02-25

摘要/Abstract

摘要： 目的探讨亚临床甲状腺功能减退症(subclinical hypothyroidism,SCH)患者血清促甲状腺激素(thyroid stimulating hormone,TSH)水平与冠脉病变严重程度的相关性。方法收集经冠脉造影确诊为冠心病的患者246例,根据血清TSH的水平分为亚临床甲减组126例及甲功正常组120例;计算亚临床甲减组冠脉病变SYNTAX评分。采用Spearman分析TSH水平与冠脉病变严重程度的相关性。结果(1)亚临床甲减组与甲功正常组患者的年龄、性别、吸烟史、高血压病患病率、收缩压、舒张压相比较,差异无统计学意义(P>0.05)。(2)亚临床甲减组TSH、TC、TG、LDL-C、AIP均高于正常组,差异有统计学意义(P<0.05)。(3)亚临床甲减组中高分组TSH、TC、TG、LDL-C、AIP高于中分组及低分组、中分组高于低分组,差异有统计学意义(P<0.05)。Spearman相关分析显示,TSH与SYNTAX评分呈正相关(r=0.768,P<0.001)。结论亚临床水平的TSH升高是冠心病的危险因素之一,且与冠状动脉病变严重程度之间存在正相关性。

关键词: 冠心病, 亚临床甲状腺功能减退症, SYNTAX评分, 血浆致动脉硬化指数

Abstract: Objective To study the correlation between the level of thyroid stimulating hormone(TSH)and the severity of coronary artery disease in patients with subclinical hypothyroidism(SCH).Methods 246 patients with coronary heart disease diagnosed by coronary angiography, according to the level of serum TSH, were selected and divided into subclinical hypothyroidism group(126 patients)and normal nail function group(120 patients), and the SYNTAX score of coronary artery disease in subclinical hypothyroidism group was calculated. Spearman was used to analyze the correlation between TSH level and severity of coronary artery disease. Results There was no significant difference in age, sex, smoking history, prevalence of hypertension, systolic blood pressure and diastolic blood pressure between subclinical hypothyroidism group and normal group(P>0.05).The TSH,TC, TG, LDL-C, AIP in subclinical hypothyroidism group were higher than those in normal group, the difference was statistically significant(P<0.05). The TSH, TC, TG, LDL-C, AIP were higher than middle group and low group、middle group were higher than low group in subclinical hypothyroidism group, the difference was statistically significant(P<0.05). Spearman correlation analysis showed that TSH was positively correlated with SYNTAX score(r=0.768, P<0.001). Conclusion The increase of TSH at subclinical level is one of the risk factors of coronary heart disease, and has a positive correlation with the severity of coronary artery disease.

Key words: coronary heart disease, subclinical hypothyroidism, SYNTAX score, plasma arteriosclerosis index

中图分类号:

于莹,李晓盼,付然,宋朕,王超. 亚临床甲状腺功能减退患者血清促甲状腺激素水平与冠脉病变的相关性[J]. 医学研究与教育, 2020, 37(1): 41-46.

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亚临床甲状腺功能减退患者血清促甲状腺激素水平与冠脉病变的相关性

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