Advances on chronic heart failure in minipig models

doi:10.3969/j.issn.1674-490X.2016.05.009

Abstract

Abstract: Chronic heart failure(CHF)is a complex cardiovascular syndrome.The establishment of an appropriate animal model of CHF is crucial for the study of pathogenesis and pharmacotherapy in CHF.Porcine models of chronic heart failure have became imperative because minipig is closer to human in physiopathology and anatomy.In recent years,the commonly used methods of minipig models of CHF are myocardial infarction,volume overload,pressure overload,drug-induced and ventricular rapid pacing.

Key words: chronic heart failure, animal model, minipig, myocardial infarction

CLC Number:

R541

YING Chenting,FAN Ziyu,NIU Xiaolong. Advances on chronic heart failure in minipig models[J]. Medical Reserch and Education, 2016, 33(5): 40-43.

References

[1] 中华医学会心血管病学分会,中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2014[J] .中华心血管病杂志,2014,42(2):98.DOI:10.3760/cma.j.issn.0253-3758.2014.02.004.
[2] 王靓,黄金玲,施慧,等.对慢性心力衰竭实验动物模型制作方法的研究进展[J] .当代医药论丛,2014,12(10):291.DOI:10.3969/j.issn.2095-7629.2014.10.254.
[3] SCHULERI K H,BOYLE A J,CENTOLA M,et al.The bottleneck stent model for chronic myocardial ischemia and heart failure in pigs[J] .AJP-Heart and Circulatory Physiology,2013,305(9):H1297-H1308.DOI:10.1152/ajpheart.005612013.
[4] KARL H S,ANDREW J B,MARCO C,et al.The Adult Gttingen Minipig as a model for chronic heart failure after myocardial infarction: focus on cardiovascular imaging and regenerative therapies[J] .Comparative Medicine,2009,58(6):568-579.
[5] SCHULERI K H,CENTOLA M,CHOI S H,et al.CT for evaluation of myocardial cell therapy in heart failure?: a comparison with CMR imaging[J] .Jacc Cardiovascular Imaging,2011,4(12):1284-1293.DOI:10.1016/j.jcmg.2011.09.013.
[6] 孙帅,郭涛.冠状动脉堵闭法与栓塞法制备小型猪心肌梗死模型的对比[J] .中国组织工程研究与临床康复,2009,13(50):9913-9916.DOI:10.3969/j.issn.1673-8225.2009.50.023.
[7] TARKIA M,STARK C,HAAVISTO M,et al.Cardiac remodeling in a new pig model of chronic heart failure: Assessment of left ventricular functional,metabolic,and structural changes using PET,CT,and echocardiography[J] .Journal of Nuclear Cardiology,2015,22(4):655-665.DOI:10.1007/s12350-015-0068-9.
[9] 彭鹏,孙嘉康,叶振,等.小型猪二尖瓣返流联合多点结扎法建立慢性心力衰竭模型[J] .中国循环杂志,2014,29(增刊1):40-41.
[10] 宗刚军,吴刚勇,夏阳,等.一种慢性主动脉瓣关闭不全动物模型建立的实验研究[J] .心脏杂志,2013,23(6):723-726.
[11] 陈翔,王飞宇,谭洪文,等.经导管建立大动物急性主动脉瓣关闭不全模型的实验研究[J] .介入放射学杂志,2014,23(7):615-618.DOI:10.3969/j.issn.1008-794X.2014.07.18.
[12] 马周瑞,于云鹏,蒲田,等.幼猪主动脉缩窄模型的术式探讨[J] .上海交通大学学报（医学版）,2013,33(11):1431-1435.DOI:10.3969 /j.issn.1674-8115.2013.11.001.
[13] 李继军,王斐,朱丽敏,等.主动脉峡部环扎构建猪导管前型主动脉缩窄模型[J] .上海交通大学学报（医学版）,2014,34(1):40-43.DOI:10.3969 /j.issn.1674-8115.2014.01.008.
[14] 徐创业,蔺嫦燕.大动物心衰模型研究进展[J] .北京生物医学工程,2013,32(5):537.DOI:10.3969/j.issn.1002-3208.2013.05.18.
[15] 李梅秀,田国忠,欧叶涛,等.大鼠阿霉素慢性心衰模型的制备与心衰指标的判定[J] .解剖学研究,2005,27(3):176-178.DOI:10.3969/j.issn.1671-0770.2005.03.006.
[16] 师幸伟,程冕,白融,等.阿霉素诱导兔心衰模型的建立与评价[J] .动物医学进展,2013,34(3):44-47.DOI:10.3969/j.issn.1007-5038.2013.03.011.
[17] 侯应龙.心动过速性心力衰竭[J] .中国心脏起搏与心电生理杂志,2002,16(6):472.DOI:10.3969/j.issn.1007-2659.2002.06.018.
[18] 张超群,王志荣,顾万华,等.快速心房起搏制作猪心动过速心肌病动物模型研究[J] .徐州医学院学报,2013,33(4):243-245.DOI:10.3969/j.issn.1000-2065.2013.04.008.

[1]	. [J]. Journal of Hebei Medical College for Continuing Education, 2023, 40(3): 38-45.
[2]	. [J]. Journal of Hebei Medical College for Continuing Education, 2023, 40(2): 25-32.
[3]	ZHANG Hongqiang, ZHANG Bing, LI Jianqi, JU Hailong. Mesenchymal stem cells for cardiac repair: opportunities and challenges [J]. Journal of Hebei Medical College for Continuing Education, 2022, 39(5): 25-30.
[4]	. [J]. Journal of Hebei Medical College for Continuing Education, 2021, 38(5): 45-50.
[5]	. [J]. Journal of Hebei Medical College for Continuing Education, 2021, 38(3): 56-61.
[6]	. [J]. Journal of Hebei Medical College for Continuing Education, 2020, 37(6): 7-13.
[7]	. [J]. Medical Reserch and Education, 2019, 36(3): 1-7.
[8]	. [J]. Medical Reserch and Education, 2018, 35(1): 25-30.
[9]	ZHANG Lanfang,JIA Xinwei,WANG Zhanqi,XIE Junmin,HAN Kunpeng. Protection of Rosuvastatin combined with Diltiazem in patients with AMI undergoing percutaneous coronary intervention [J]. Medical Reserch and Education, 2016, 33(3): 1-5.
[10]	ZHANG Lanfang,JIA Xinwei,WANG Zhanqi,XIE Junmin,HAN Kunpeng. Protection of Rosuvastatin combined with Diltiazem in patients with AMI undergoing percutaneous coronary intervention [J]. Medical Reserch and Education, 2016, 33(3): 1-5.
[11]	TIAN Zhiyu, ZHAO Wenping, JIA Xinwei, XU Jingjing, PAN Huanjun, LI Ya, ZHAO Shujun. Application research on BNP in acute myocardial infarction patients with primary percutaneous coronary intervention [J]. Medical Reserch and Education, 2015, 32(2): 24-29.
[12]	XIAO Nuan, TANG Luning, TAN Lili, CHEN Yaqing, ZHAO Hongmei. Research progress of WBC count and the prognosis of acute myocardial infarction [J]. Medical Reserch and Education, 2014, 31(6): 89-94.
[13]	ZHANG Jing,CHEN Chunhong,WANG Yanfei. Effects of early Tiroifban Hydrochloride on platelet aggregation rate and prognosis in patients with non-ST-segment elevation myocardial infarction [J]. Medical Reserch and Education, 2014, 31(3): 25-28.
[14]	. Efficacy of H-FABP and IMA in the early diagnosis of acute myocardial infarction [J]. Medical Reserch and Education, 2013, 30(2): 34-36.
[15]	. Stem cells for cardiac repair in acute myocardial infarction [J]. Medical Reserch and Education, 2012, 29(6): 60-64.