Effects of perna viridis polysaccharides on apoptosis of cervical cancer cell and expression of miRNA-34a

doi:10.3969/j.issn.1674-490X.2014.02.001

Abstract

Abstract: Objective To investigate the effects of perna viridis polysaccharides (PVPS) on apoptosis of cervical cancer cell and expression of miRNA-34a. Methods Cervical cancer cells were treated with PVPS (100 mg/L) for 48 hours, then flow cytometry was used to analyse apoptosis and real-time quantitative PCR to detect expression of miRNA-34a. Results Compared with control group, PVPS can significantly rise the apoptosis rate (P<0.001) and expression of miRNA-34a (P<0.01) in cervical cancer cell. Conclusion PVPS can induce apoptosis of cervical cancer cell by elevate expression of miRNA-34a.

Key words: perna viridis, polysaccharides, cervical cancer, apoptosis, miRNA

CLC Number:

R966

LAI Yinxuan,HE Dongmei,YANG Limei,LIU Xinguang,LI Jiangbin. Effects of perna viridis polysaccharides on apoptosis of cervical cancer cell and expression of miRNA-34a[J]. Medical Reserch and Education, 2014, 31(2): 1-3.

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Effects of perna viridis polysaccharides on apoptosis of cervical cancer cell and expression of miRNA-34a

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