Journal of Hebei Medical College for Continuing Education

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Effects ofα-zeranol on the IL-6 expression and secretion in rat osteoblasts

DUAN Fei,HAO Huachao,XUE Juan,LI Shaochun,LIU Weihua,GU Yu,SUN Xiaofang

Medical Reserch and Education 2014, 31 (1): 1-7. DOI: 10.3969/j.issn.1674-490X.2014.01.001

Abstract （387）

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Objective To investigate the effects ofα-zeranol on the IL-6 expression and secretion in rat osteoblasts. Methods Osteoblasts were isolated from the skull of SD neonatal rats and identified by morphological observation, ALP staining, and collagen I immunolfuorescence staining. 17β-estradiol andα-zeranol with different concentration were administrated. The expression of IL-6 mRNA in the osteoblasts was detected by RT-PCR and the level of IL-6 in culture supernatant of osteoblasts was measured by ELISA. Results α-zeranol with 10-10~10-5 mol/L concentrations could inhibit the expression and secretion of IL-6 in osteoblasts, among which the concentrations of 10-6 and 10-7 mol/L had obvious effects. Conclusionα-zeranol can inhibit the expressions of IL-6 mRNA and protein in osteoblasts, it may play an important role in the prevention of postmenopausal osteoporosis.

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Study on sperm membrane ultrastructure of non-abstructive infertile male

WANG Ran,YIN Huiying,GUO Mingshen,LIU Shuzhuo,GE Shaoqin

Medical Reserch and Education 2014, 31 (1): 8-12. DOI: 10.3969/j.issn.1674-490X.2014.01.002

Abstract （308）

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Objective To explore the inlfuence of sperm membrane ultrastructure damage on the non-obstructive infertile male. Methods After embedding the fresh semen from one case of infertile male, using transmission electron microscopy (TEM) to observe the sperm plasma membrane, outer acrosomal membrane , inner acrosomal membrane etc. Results Under the electron microscope, the defects of plasma membrane, outer acrosomal membrane and inner acrosomal membrane in the semen sperm of this infertile man were examined, with some of other abnomal spermultrastructures observed, such as defects in the sperm acrosome, nucleus, neck, mitochondrial and microtubules. Conclusion The non-obstructive male infertility is closely related to the abnormality of sperm membrane ultrastructure.

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Expression and puriifcation of Survivin gene fusion protein

LI Li,LIU Jing,JIANG Jizhi

Medical Reserch and Education 2014, 31 (1): 13-16. DOI: 10.3969/j.issn.1674-490X.2014.01.003

Abstract （313）

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Objective Survivin gene is the strongest apoptosis-inhibition factor among inhibitor of apoptosis protein (IAP), and purification of fusion protein of functional domains (baculovirus IAP repeat, BIR) may provide the foundation for interaction research between the gene and related other genes. Methods BIR sequence, after ampliifcation with PCR and validation by Escherichia coli DH5αthrough pGEX4T-2 vector, was transformed into E. coli BL21. Fusion protein of BIR was induced by IPTG and puriifed by Glutathione Agarose Affinity Chromatography. Results The amplified fragment BIR was about 276bp, purified fusion protein molecular weight of approximately 37ku. Conclusion PCR results are consistent with the expected fragment size, recombinant plasmids after 2h after IPTG induction, the cell in the fusion protein increase signiifcantly, which provide basis for further research on Survivin gene function and its interacting protein.

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The changes of serum amyloid A (SAA), plasma D-dimer and tumer marker CA724 for predicting tumor metastasis of patients with colorectal cancer

HU Ling,SU Lei,SHANG Yanhong,WANG Zhiyu,LI Xiaofang,JIAO Jin,CHEN Chunyan

Medical Reserch and Education 2014, 31 (1): 17-20,45. DOI: 10.3969/j.issn.1674-490X.2014.01.004

Abstract （431）

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Objective To explore the changes of serum amyloid A (SAA), plasma D-dimer and tumer marker CA724 for predicting tumor metastasis of patients with colorectal cancer. Methods Preoperative SAA, D-dimer and CA724 were measured in 58 patients with colorectal and 55 patients with benign disease, and they were analyzed with statistics method. In addition, according to pathological TNM (AJCC/UICC TNM), the patients with colorectal were divided into no metastasis group, regional lymph node metastasis group and distant metastasis group for comparing SAA, D-dimer and CA724 between groups. Results SAA, D-dimer and CA724 levels were signiifcantly higher in patients with colorectal carcinoma than those with benign diseases (P<0.05). SAA test showed that there was statistical significance between no metastasis group, regional lymph node metastasis group and distant metastasis group, and there was no statistical signiifcance by CA724. SAA and D-dimer levels in distant metastasis group were obviously higher than that of no metastasis group and regional lymph node metastasis group (P<0.05). Conclusion There is guiding signiifcance for conifrming regional lymph node metastasis and distant metastasis in patients with colorectal to detect SAA CA724 and D-dimer levels.

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Relationship between expression of PTEN and survival prognosis of NSCLC

WANG Ying,ZHANG Xiaopeng

Medical Reserch and Education 2014, 31 (1): 21-23. DOI: 10.3969/j.issn.1674-490X.2014.01.005

Abstract （305）

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Objective To study the relationship between expression of PTEN and survival prognosis of NSCLC. Methods 62 cases with non-small cell lung cancer conducted radical surgical resection and 14 cases done adjacent normal tissue were selected and examined PTEN protein by immunohistochemical SP method to explore its relationship with the survival of the patients. Results The results indicated that there were statistically significant differences between PTEN expression of cancer and normal tissues adjacent groups. There were statistically signiifcant differences about the PTEN expression between the positive group and the negative group (P<0.05). Conclusion The low expression of PTEN in non-small cell lung cancer shows that PTEN plays an important role in the development of non-small cell lung cancer, which is signiifcantly associated with the survival time of the patients.

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Expression of osteopontin and adhesion molecule CD44v6 in colon adenocarcinoma and their clinical signiifcance

ZHANG Ye,BIAN Yongsheng,LIU Jinzhong

Medical Reserch and Education 2014, 31 (1): 24-27. DOI: 10.3969/j.issn.1674-490X.2014.01.006

Abstract （329）

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Objective To investigate expression of osteopontin (OPN) and adhesion molecule CD44v6 in colon adenocarcinoma and their clinical signiifcance. Methods 80 cases of colon cancer tissue were detected by immunohistochemical methods (with lymph node metastasis in 32 cases, 48 cases without lymph node metastasis), 30 cases of colorectal adenoma, 20 cases from colon tumor (polyp, adenoma, cancer, etc.) 5 cm above normal tissue osteopontin and CD44v6 expression levels were examined to analyze the correlation of osteopontin and CD44v6 expression in colon adenocarcinoma. Results Adenocarcinoma of the colon and surrounding lymph nodes, osteopontin and CD44v6 expression were signiifcantly higher than that of normal colon tissue and colonic adenoma expression levels (P<0.05), colon adenocarcinoma with metastasis in osteopontin CD44v6 protein expression levels were significantly higher than that of non-metastatic colon adenocarcinoma (P<0.05). Colon adenocarcinoma osteopontin expression and expression of CD44v6 were in a state of consistency (P<0.05). Conclusion OPN-CD44v6 with colon adenocarcinoma, developing consistent, osteopontin and CD44v6 joint detection for colon cancer development and prognosis explicitly provide a basis for clinical diagnosis and treatment , which has a certain signiifcance in clinical practices.

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Comparative analysis of outcomes on antituberculosis ifxed-dose combination and plate combination drug in treatment with patients with initial tuberculosis

ZHANG Jinguo,ZHANG Baozong,ZHANG Yan,WANG Yanhui,SUN Xiaoli,YU Jian

Medical Reserch and Education 2014, 31 (1): 28-32. DOI: 10.3969/j.issn.1674-490X.2014.01.007

Abstract （598）

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Objective To get the clinical comparative observation on outcomes of antituberculosis fixed-dose combination and plate combination drug with initial tuberculosis treatment, providing a scientiifc basis for the antituberculosis fixed-dose combination clinical application. Methods Patients with initial treatment tuberculosis were divided into treatment group and the control group. The treatment group was treated with anti tuberculosis ifxed-dose combination, while the control group was treated with plate combination drug. Two groups all used the alternate day therapy program (2H3R3Z3E3/4H3R3). Observe the treatment completion, loss, program change and discontinuation of the medicine of the two groups with the method of control study. Results For the tuberculosis patients of initial treatment smear-positive and initial treatment smear-negative, the treatment completion rate of antituberculosis ifxed-dose combination group was greater than that of plate combination drug group(P<0.05). Loss rate of antituberculosis fixed-dose combination group was less than that of plate combination drug group(P<0.05). Program change rate of antituberculosis ifxed-dose combination group was less than that of plate combination drug group(P<0.05). The rate and the frequency of discontinuation of the medicine of antituberculosis ifxed-dose combination group was less than that of plate combination drug group(P<0.05). Conclusion Antituberculosis fixed-dose combination is advantageous to help medical staff on patient therapy management and supervision, and the application of it in the National Tuberculosis control programme is feasible.

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Retrospective report of clinical characterizations of an Enterobacter cloacae carrying NDM-1 associated with urinary tract infection

CAO Lijun,YANG Jing,GENG Fengzhen,LI Huiqing,SHI Zheng,SHI Dongyan

Medical Reserch and Education 2014, 31 (1): 33-36. DOI: 10.3969/j.issn.1674-490X.2014.01.008

Abstract （339）

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Objective A retrospective analysis in terms of clinical characteristics and detection was carried out for a case of Enterobacter cloacae bearing NDM-1 isolated from a urine specimen of an in-patient in our hospital in July 2012. The purpose of this paper was to render suggestions for controlling the epidemic of“superbugs”based on discussions regarding its antibiotic-resistant characterization and mechanism. Methods According to the recommendations of CLSI, susceptibility testing for antibiotics using K-B and MIC methods was performed. Carbapenemase production and its phenotypic were confirmed by modified Hodge test and metal-enzyme test. PCR for detecting and sequencing the antibiotic-resistance gene was also performed. Results This isolate was resistant to 15 antibiotics such as imipenem, meropenem and others which were classiifed into 7 categories. This isolation showed positive for modiifed Hodge test and screening test for detecting metal-enzyme phenotype. The DNA sequence of the isolation amplified by PCR showed 99%similarities comparing with NDM-1 gene cited in Genbank. It was conifrmed as the ifrst report of E. cloacae carrying NDM-1 by the CDC of Heibei Province.Conclusion The NDM-1-producing isolation may be related to the elder patient who was inifrm, catheterized and experienced multi-drug treatments. Therefore, in order to lessen the incidents of multi-drug resistant strain, it is ideal that we should focus on the control over catheterization, the use of antibiotics and taking strict sterilization.

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The rehabilitation guide of Shi’ Jiegudan combined with small splint immobilization in treatment of Colles fracture

ZHANG Caifen,JIA Siyue,WANG Feiran,SHI Han,SHI Shaobing,WU Liping,XU Yingjie

Medical Reserch and Education 2014, 31 (1): 37-40. DOI: 10.3969/j.issn.1674-490X.2014.01.009

Abstract （326）

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Objective To observe the clinical curative effects of manual diaplasis and small splint immobilization combined with rehabilitation guide in treatment of Colles fracture. Methods 68 cases with stable Colles fracture were treated with manual diaplasis, small splint immobilization and Shi’ Jiegudan, and given rehabilitation guide. The clinical curative effect of 3 months was appraised. Results All patients were followed up for 4-10 months with an average of 6 months. All of them achieved bony union and clinical healing standard. Clinical healing time was 21-39 days with an average of (28.02±1.64) days. 65 cases were cured, 3 cases improved. The cure rate was 95.59%, and the total efifciency was 100%. Conclusion The rehabilitation guide of the patients treated with small splint immobilization is effective clinically. It is worthy for being widely used in clinical orthopedics.

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Researches on randomized controlled trials of patients with shoulder-hand syndrome after stroke by routine rehabilitation training combined with medium-frequency electrotherapy

SHI Cuixia,XIE Ruijuan,WANG Xiaohong,YANG Yanling,DENG Yun,CHEN Lu

Medical Reserch and Education 2014, 31 (1): 41-45. DOI: 10.3969/j.issn.1674-490X.2014.01.010

Abstract （317）

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Objective To observe the effects of routine rehabilitation training combined with medium-frequency electrotherapy in the treatment of patients with shoulder-hand syndrome after stroke. Methods 84 cases with shoulder-hand syndrome after stroke were randomly divided into the treatment group ( 42 cases )and a control group ( 42 cases). Two groups were given rehabilitation training for 4 weeks, and the treatment group received medium-frequency electrotherapy meanwhile. Upper limb motor functions, activities of daily living and upper extremity pain and swelling were measured apart by the Fugl-Meyer assessment, MBI index, and visual analog scores. The indicators before and after treatment were compared. Results There were 80 patients completed the trial (including treatment group 40 cases, control group 40 cases), and two group patients’ upper limb pain, edema, FMA and MBI scores compared with those before the treatment were signiifcantly improved (P<0.05), the treatment group improved more signiifcantly than that of the control group (P<0.05), the efifciency of the treatment group and the total efifciency was better than that of the control group (P<0.05). Conclusion Routine rehabilitation training combined with medium-frequency electrotherapy is a good method for the treatment of shoulder hand syndrome after stroke.

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Resecting large primary dumbbell tumor tangled with abdominal organs in lumbar region through single-stage posterior approach

ZHENG Yang,LI Jing

Medical Reserch and Education 2014, 31 (1): 46-50. DOI: 10.3969/j.issn.1674-490X.2014.01.011

Abstract （278）

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Objective To evaluate the feasibility, safety and effect of resection large spinal-retroperitoneal dumbbell tumor tangled with vital abdominal organs through independent posterior approach. Methods 18 patients' clinical data, operation records, pathologic examination results and follow-up data were included in this retrospective analysis. In the initial 8 patients, combined surgical approaches from back and front were used. The later 10 patients were operated on using an independent improved posterior approach to remove tumor. Results In earlier 8 patients who underwent a combined surgery from posterior and antero-lateral approaches, total surgical time averaged 5 hours, the blood loss averaged 800 mL. 1 patient died of brain metastasis 5 months post-surgically. 7 cases symptoms disappeared, no tumor recurrence. In later 10 patients, only independent posterior approach was used, operative time averaged 3 hours, blood loss averaged 450 mL. All patients were not tumor recurrence and symptoms disappear. Conclusion Primary large dumbbell tumor in lumbar region which tangles with abdominal organ can be safely removed through independent posterior approach. Compared with combined posterior and anterior approaches, independent posterior approach is more simple, less traumatic, and similarly effective.

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Observation on the effects of dialectical applying ear acupuncture point buried beans in alleviating pain in patients with primary dysmenorrheal

XU Haixia,LYU Derong,SHU Chanjuan

Medical Reserch and Education 2014, 31 (1): 51-53,82. DOI: 10.3969/j.issn.1674-490X.2014.01.012

Abstract （313）

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Objective To observe the effects of dialectical applying ear acupuncture point buried beans to reduce the pain in justification of common type of primary dysmenorrheal. Methods Fifty cases of patients with primary dysmenorrhea in after syndrome differentiation were given corresponding ear acupuncture point buried beans. 0.5 h later pain reliefs with patients were assessed and the recurrence of the patients with periodic pain was examined. Results In iffty patients with various types of primary dysmenorrheal, 49 cases eased the pain in half an hour, the total effective rate was 98.0%. In 36 patients with periodic pain, 31 cases relieved, the effective rate was 86.1%. Conclusion The method of dialectical applying ear acupuncture point buried beans can effectively alleviate pain in patients with primary dysmenorrhea.

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Study on the disinfection of pretreatment of pancreatic enzyme on pulmonary tuberculosis patients with sputum smear-positive

ZHANG Yongqiang,LIU Lanrui,ZHANG Jinguo,ZHU Ning

Medical Reserch and Education 2014, 31 (1): 54-56. DOI: 10.3969/j.issn.1674-490X.2014.01.013

Abstract （327）

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Objective To evaluate the effects of chlorine-containing disinfectant on TB sputum preprocessed by pancreatic enzyme. Methods 116 samples from sputum smear-positive pulmonary tuberculosis patients collected from outpatient service were randomly divided into the control group and treatment group. 58 samples of TB sputum in treatment group were preprocessed by 5%pancreatic enzyme disinfector, then to 84 disinfector of containing 5 000 mg/L chlorine. The 58 samples in control group, were directly processed by 84 disinfector of containing 5 000 mg/L chlorine. After 0.5 h, 1 h and 2 h of the treatment, the positive rates of mycobacterium tuberculosis of each sputum samples were comparatively analyzed. Results The positive rates of mycobacterium tuberculosis of 0.5 h, 1 h and 2 h in control group were 100%, 88%and 100%respectively. After pretreatment of pancreatic enzyme, the positive rates of 0.5 h, 1 h and 2 h in treatment group were 62%, 14%and 0 respectively.Conclusion The pretreatment of pancreatic enzyme on sputum of pulmonary tuberculosis patients can obviously promote the disinfectant effects. It should be actively promoted in disinfectants on TB sputum.

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Study of the inlfuence of internet on learning status of medical students

WU Han,JIN Tianxing,WANG Feiran,ZHANG Liwen

Medical Reserch and Education 2014, 31 (1): 57-60. DOI: 10.3969/j.issn.1674-490X.2014.01.014

Abstract （309）

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Objective To study the diversity between medical students with internet addiction and the control and analyze the effecst of internet addiction. Methods 687 medical students were conducted with retrospective investigation on the situation of internet use over the past semester. Results The rates of internet addiction and internet dependence were 4.8% and 8.3% respectively. The academic record, skipping classes depended on internet, net play in classes, preferences of after-school activities and the purpose of net play had signiifcantly differences between internet addiction group and the controls(P<0.05). Conclusion Internet addiction has a negative impact on study.

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Physical activity effected by fast walking in elderly patients with type 2 diabetic disease

LI Yanling,ZHANG Wei,ZHANG Jinli,FENG Na,XU Haojun

Medical Reserch and Education 2014, 31 (1): 61-65. DOI: 10.3969/j.issn.1674-490X.2014.01.015

Abstract （303）

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Objective To evaluate the effects of fast walking exercise on the physical activity in elderly patients with type 2 diabetes (T2DM) in glucose metabolism and physical activity indicators. Methods 80 patients with T2DM were randomly divided into two groups:exercise group and the control group, 40 cases in each group. Exercise group performed on 16 weeks of fast walking, before the movement of glucose metabolism and physical activity indicators were compared. Results The experimental group iftness program VO2max before and after exercise, 30s arm lfexion and extension, 2min standing still, chair-reach, grab the back stretch, 6min walk, six test scores were signiifcantly increased (P<0.05). While continuous improvement 30s standing and sitting in the chair stand test results go two (P<0.01). In the control group it had no signiifcant improvement after the test. Patients in the control group iftness body each index changed little (P>0.05). 2h postprandial blood glucose (2hPG) decreased significantly (P<0.05), glycosylated hemoglobin (HbAlc), postprandial 24h urine positive rate, fasting urine positive rate was signiifcantly lower (P<0.01) fasting plasma glucose (FPG), fasting insulin (Flns) and 2h postprandial insulin (2hIns) levels did not change signiifcantly (P>0.05). Lower extremity muscle strength tests comparing exercise group had ankle flexion and extension muscle strength growth to varying. Conclusion Fast walking exercise training program will help to improve glucose metabolism and activity in patients with T2DM.

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Subjective well-being of female patients with urinary incontinence inlfuenced by spouse synchronization of health education

YAN Hongli,ZHANG Jinli,ZANG Weidong,ZHANG Wei,LIU Fengmin,TAO Yingbin

Medical Reserch and Education 2014, 31 (1): 66-69. DOI: 10.3969/j.issn.1674-490X.2014.01.016

Abstract （308）

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Objective To investigate how spouse synchronization of health education affects the subjective well-being of the female patients with urinary incontinence. Methods 106 cases with urinary incontinence of healthy spouse were randomly divided into two groups. In observation group 53 cases of patients and their spouses simultaneous implementation of health education. In the control group, 53 cases were only received health education to herself. Results Before the education, the difference between Health Education Social Support Rating Scale for four groups of patients and SWB was no statistically signiifcance (P>0.05). After conducting spouse synchronization of health education one month, 3 months, the different indicators and SWB scores of the experimental group were higher than that of the control group (P<0.05). Conclusion Through conducting the spouse synchronous of health education, the social supports can be signiifcantly increased, and it is also helpful for the patients to get quick recovery.

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Advances on the treatment and clinical assessment in Mayer-Rokitansky-Kuster-Hauser syndrome

LI Yachai,GAO Xinping,HUANG Xianghua

Medical Reserch and Education 2014, 31 (1): 70-78. DOI: 10.3969/j.issn.1674-490X.2014.01.017

Abstract （425）

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To solve the problem of sexual roles and sexual life of patients with Mayer-Rokitansky-Kuster-Hauser syndrome, the functional vagina need to be established. Non-surgical and surgical treatments were commonly in clinical at present. Numerous studies have described different methods of vaginoplasty and assessed clinical outcomes including the anatomy and function of the artiifcial vagina, long-term prognosis, and the complication rate. The most appropriate treatment methods are choiced by doctors according to the patient's condition and surgeon experiences.

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The mechanisms of NK cells in killing Toxoplasma gondii and the role of traditional Chinese medicine in its regulation

WU Dan,XIAO Beilei,LI Xiaodong,WANG Feiran,YANG Moyuan,WANG Weiqiang

Medical Reserch and Education 2014, 31 (1): 79-82. DOI: 10.3969/j.issn.1674-490X.2014.01.018

Abstract （317）

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The killing activity of NK cells, whose main target cells are some tumor cells, cells infected by virus, tissue cells and parasites, etc, has no MHC restriction, and does not rely on antibody, so it plays an important role in the immune response to toxoplasma infection in cells. The following will review the Chinese herb ingredient which affects the activity of NK cells to kill toxoplasma and the mechanisms of NK cell in killing Toxoplasma gondii.

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The inlfuencing factors about the compliance of antipsychotics and intervention strategies

YU Xuezhu

Medical Reserch and Education 2014, 31 (1): 83-86. DOI: 10.3969/j.issn.1674-490X.2014.01.019

Abstract （338）

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The article reviewed the recent research progress of the compliance of antipsychotics. The content included the definition and the related factors of compliance. It described the intervention strategies of improving compliance, such as psychosocial intervention, procedural intervention, drug intervention, and so on. It also discussed the limitation of the present research and future research direction about the compliance of antipsychotics.

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Study on detection method for cerebral neurotransmitter dopamine

ZHANG Qingyun,LI Jialin,ZHENG Pei,LI Yanxia,CHE Yuxuan,DONG Xiaodong

Medical Reserch and Education 2014, 31 (1): 87-90. DOI: 10.3969/j.issn.1674-490X.2014.01.020

Abstract （753）

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Dopamine is a special neurotransmitter in human brain, and the abnormal changes of its content will result in the emergence of clinic illness, such as Parkinson’s disease. How to detect the dopamine simply and quickly is an important topic concerned by the researchers all over the world. The usual detection methods include spectrophotometry, chemiluminescence method, chemical lfuorescence method, liquid chromatography, electrochemical method, et al. In this article the studies of detection methods for dopamine in recent years are reviewed.

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Research progress of Chinese herb prevention and treatment of pulmonary ifbrosis at the molecular level

XUE Juan,LIU Weihua,DUAN Fei,SUN Xiaofang,LI Shaochun,GUO Yongqing,LI Jian,LI Xiaoqing

Medical Reserch and Education 2014, 31 (1): 91-94. DOI: 10.3969/j.issn.1674-490X.2014.01.021

Abstract （353）

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Some single Chinese herb can be used for the prevention and treatment of pulmonary ifbrosis.First of all, this paper describes the mechanism of pulmonary fibrosis in cell and molecular level. Secondly, this paper describes single Chinese herb prevention and treatment of pulmonary fibrosis experiment progress in cell and molecular level to ifnd the prevention and treatment of pulmonary ifbrosis drug targets as a theoretical basis for clinical treatment.

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The application and evaluation about the anchored instruction strategy in general nursing practice teaching

JING Kunjuan,CUI Fengying,ZHANG Liran

Medical Reserch and Education 2014, 31 (1): 95-100. DOI: 10.3969/j.issn.1674-490X.2014.01.022

Abstract （312）

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Objective To explore anchored instruction strategy in the application of general nursing practice teaching and evaluation. Methods The three-year higher vocational nursing students as investigating object were investigated, anchored instruction strategy based on constructivism learning theory to general nursing training classes for the teaching design and application designed teaching effect after implementation of the questionnaire were conducted. Results 94.1%of the students considered that the application of this teaching strategy was helpful to stimulate the learning interest, and cultivate the information search, analysis and solving problems abilities, and the ability of cooperation to help others, but also shortened the gap between theory and practice. Conclusion The anchored instruction strategy applied in general nursing training courses has signiifcant difference in cultivating good information literacy and innovation ability of nursing students.

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Study on the advantages of merging two courses---Child and Adolescent Health and Child Care

WANG Tingting,LYU Xin,LI Rong,SHAO Hong

Medical Reserch and Education 2014, 31 (1): 101-104. DOI: 10.3969/j.issn.1674-490X.2014.01.023

Abstract （296）

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Objective To study the advantages and theoretical basis of merging the two courses ---Child and Adolescent Health(CAH), Child Care(CC). Methods Comparative analysis was used to compare the contents of the course syllabus and teaching plans of CAH and CC with the public health physician examination syllabus. Results The results showed that most of the contents of CAH and CC were repeated, as the same knowledge of this two courses was taught respectively, more class hours were spent. This study found that the same knowledge of the two courses still play important role after the two courses had been merged. In addition they conformed to the contents of the public health physician examination syllabus. Conclusion Repeating the same contents and wasting class hours could be avoided by merging the two courses, the connections of this two courses could be enhanced by this way, contents of merging conform to the public health physician examination syllabus.

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Discussion on the management of practical teaching and improvement the quality of clinical teaching

SU Huixuan,ZHOU Huiping

Medical Reserch and Education 2014, 31 (1): 105-107. DOI: 10.3969/j.issn.1674-490X.2014.01.024

Abstract （256）

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Clinical practice for medical students is a process of combining basic medical theory with clinical skills, which is a critical stage of medical education. The authors realize that it can improve the quality of clinical teaching by optimizing the management of practical teaching, strengthening teaching organization, perfecting teaching system, training the teachers' comprehensive qualities and strengthening the standardized management of clinical teaching and teaching supervision.

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Apply of problem-based learning in clinical practice of thoracic oncological surgery

SUN Xiaohong,CHEN Ling,LUO Dongbo,OU Jianghua

Medical Reserch and Education 2014, 31 (1): 108-110. DOI: 10.3969/j.issn.1674-490X.2014.01.025

Abstract （292）

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Objective To investigate the role of PBL teaching method in clinical practice of thoracic oncological surgery. Methods 34 students of clinical medical specialty in Xinjiang Medical University were randomly divided into PBL group (Problem-based learning group, n=17) and (traditional LBL group traditional lecture-based learning group, n=17). The effectiveness of these two different teaching group were compared. Results Both average scores of common knowledge and clinical case analysis in PBL group were signiifcantly higher than those of LBL group. The student's ability of self learning, the way of clinical thinking and the capability of knowledge understanding in PBL group were signiifcantly better than those in LBL group. Conclusion The way of PBL can improve the effectiveness of medical student's learning in the clinical practice of thoracic oncological surgery, enhance their capability of patients treatment. The PBL teaching method in practice of thoracic oncological surgery has certain promotion value.

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Medical Reserch and Education 2014, 31 (1): 111-112. DOI: 10.3969/j.issn.1674-490X.2014.01.026

Abstract （371）

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Effects of perna viridis polysaccharides on apoptosis of cervical cancer cell and expression of miRNA-34a

LAI Yinxuan,HE Dongmei,YANG Limei,LIU Xinguang,LI Jiangbin

Medical Reserch and Education 2014, 31 (2): 1-3. DOI: 10.3969/j.issn.1674-490X.2014.02.001

Abstract （281）

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Objective To investigate the effects of perna viridis polysaccharides (PVPS) on apoptosis of cervical cancer cell and expression of miRNA-34a. Methods Cervical cancer cells were treated with PVPS (100 mg/L) for 48 hours, then flow cytometry was used to analyse apoptosis and real-time quantitative PCR to detect expression of miRNA-34a. Results Compared with control group, PVPS can significantly rise the apoptosis rate (P<0.001) and expression of miRNA-34a (P<0.01) in cervical cancer cell. Conclusion PVPS can induce apoptosis of cervical cancer cell by elevate expression of miRNA-34a.

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Research of relationship between matrix metalloproteinase-9 and carotid atherosclerosis plaque’s stability

SONG Yueping,SUN Juping,ZHOU Jinying,DI Weiying,LIU Dan,GAO Juan

Medical Reserch and Education 2014, 31 (2): 4-6. DOI: 10.3969/j.issn.1674-490X.2014.02.002

Abstract （301）

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Objective To study the relationship between matrix metalloproteinase-9 and carotid atherosclerosis plaque’s stability. Methods The bilateral carotid atherosclerosis of 48 asymptomatic carotid atherosclerosis patients(ACA group) and 20 normal controls(NC group) were examined with color Doppler. The serum levels of MMP-9 in all the groups were measured by enzyme linked immunosorbent assay. Results Carotid atherosclerosis plaque was not found in NC group. The serum levels of MMP-9 in ACA group were significantly higher than that in NC group(all P<0.05). In ACA group, the serum levels of MMP-9 in vulnerable plaque subgroup were significantly higher than that in stabled plaque subgroup(all P<0.05) and the serum levels of MMP-9 in stable plaque subgroup were signiifcantly higher than that in no plaque subgroup(all P<0.05). Conclusion The serum levels of MMP-9 can be serum markers of carotid atherosclerosis plaque and its stability index.

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The impact of Iodixanol against kidney injury molecule-1 and the renal tubular cell apoptosis in rats with renal insufifciency

WANG Xianjun,WU Shangqin,YAO Qinghai,DONG Guofeng

Medical Reserch and Education 2014, 31 (2): 7-11. DOI: 10.3969/j.issn.1674-490X.2014.02.003

Abstract （376）

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Objective To observe the impact of Iodixanol against kidney injury molecule-1 and the renal tubular cell apoptosis in rats with renal insufifciency. Methods 48 male wistar rats were randomly divided into four groups:normal control group, model group, Iodixanol group1, Iodixanol group2 (n=12). Iodixanol groups and model group were applied the methods of left renal artery narrowing (30%), right nephrectomy to produce renal insufifciency model in rats respectively, in the preoperative and postoperative 2 weeks every other day by measuring the angular vein blood BUN, SCr and taking urine test of urinary kidney injury molecule-1 (KIM-1) values. After the ifrst three weeks of intravenous saline model group, iodixanol (5 mL/kg)injection of iodixanol group 1, iodixanol (10 mL/kg)injection of iodixanol group 2, the changes of blood urea nitrogen, creatinine and urinary KIM-1 of the two iodixanol groups before applying the contrast agent, after 3 h, 24 h, 48 h, 72 h and 7 d were observed. Three rats of each group were sacriifed in 24 h, 72 h and 7th day after injection of contrast agent. The renal tubular cell apoptosis rates were measured by TUNEL and the differences of each group were compared. Results After in the ifrst two days of surgery, serum BUN, SCr levels in model group were signiifcantly higher than that of the normal group (P<0. 0 1 ) and rised sharply up to about 2 times before surgery, Then gradually decreased after surgery stable at 1.5-2.0 times the preoperative levels two weeks. But the values of KIM-1 were no signiifcant difference (P>0.05). Compared with the model group, in 24 h, 72 h and 7th day after the injection of contrast agents, the values of BUN and SCr, the value of KIM-1 in urine and the rates of apoptosis of renal tubular cells in iodixanol group 2 were signiifcantly increased higher than that of the model group (P<0.01). After three hours iodixanol injection of iodixanol group 2, urinary KIM-1 levels that increased signiifcantly earlier than the rise in the iodixanol group1, the difference was signiifcant (P<0.01). Conclusion By using the left renal artery narrowing and right nephrectomy method can be prepared with mild to moderate chronic renal failure in animal models;iodixanol can cause acute kidney injury of chronic renal failure animals and the speciifc mechanisms may induce renal contrast agent tubule epithelial cell apoptosis. KIM-1 can be used as a contrast agent nephropathy early predictors. Different concentrations of contrast agents for renal tubular injury are different.

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Effects of red LED lights on the regeneration of liver injury in rats

SUN Jiangang,LIU Shihao,DONG Hongwei,HOU Chenning,XIE Yinghui,LIU Zihao,WANG Xinyue,JI Kan,CUI Yan,LI Li

Medical Reserch and Education 2014, 31 (2): 12-16. DOI: 10.3969/j.issn.1674-490X.2014.02.004

Abstract （325）

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Objective To observe the effects of red light source on the liver regeneration of liver injury in rats. Methods Fifty experimental SD rats were randomly divided into five groups, normal control group, model group, 10 min irradiation group, 20 min irradiation group, and 30 min irradiation group, with 10 rats in each group. The blood sampling was undergone to test alanine aminotransferase and aspartate aminotransferase of all groups after 4 weeks. The livers were taken out and weighed to calculate the proportion of regeneration liver lobes weight. The liver tissues were taken to observe the regenerated liver cells of regeneration leaves with microscope. Results The alanine aminotransferase level of each treatment group was lower than that of model group (P<0.05). The aspartate aminotransferase level of the rats in 30 min irradiation group was decreased than those of model group (P<0.05). The results of pathology showed the liver cell regeneration of the treatment group was signiifcantly better than the model group (P<0.05). Compared with the model group, the proportion of the regeneration liver lobe in each treatment group was signiifcantly increased (P<0.05). Conclusion Red light could promote the regeneration capacity of the damaged liver, and help liver function recover of rats with liver injury.

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Logistic regression analysis on inlfuencing factors of medical abortion outcome

LIU Meiyun,ZHANG Hongjie,ZHU Jihong,GAO Jing

Medical Reserch and Education 2014, 31 (2): 17-20. DOI: 10.3969/j.issn.1674-490X.2014.02.005

Abstract （286）

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Objective To explore the influencing factors of medical abortion outcome, and provide evidences for making intervention measures. Methods A case-control study was adopted with cases who had incomplete or failure abortion after medical abortion, and the controls were those who had complete abortion. The data was analyzed by SPSS16.0. Results The univariate analysis showed that factors such as the surgical abortion history (χ2=4.691, P=0.030), the site of the medical abortion (χ2=13.487, P=0.000), pregnant weeks (χ2=6.747, P=0.009), whether vaginitis before medical abortion (χ2=22.153, P=0.000) were influencing the medical abortion outcome. The multivariate analysis showed that risk factors were the site of the medical abortion (OR=3.693, P=0.009)and whether vaginitis before medical abortion (OR=4.520, P=0.000). Conclusion In private clinics, the ratio of incomplete abortion or failure of medical abortion was more than that in public hospital or family planning clinics. For the women with vaginitis, the possibility of incomplete abortion or failure was greater.

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Sensitivity analysis on commonly used chemotherapy drugs in treating breast cancer cells

ZHOU Bin,Li Yuanyuan

Medical Reserch and Education 2014, 31 (2): 21-24. DOI: 10.3969/j.issn.1674-490X.2014.02.006

Abstract （417）

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Objective Through culturing breast cancer cells in vitro, and applying common chemotherapy drug sensitivity testing to provide clinical reference and choice of chemotherapy drugsto reduce the clinical chemotherapy choice blindness and get better implementation of individual treatment. Methods MTT method was applied in testing susceptibility of the tumor cells and tumor cells cultured in vitro in surgical resection of lung cancer (13 cases), esophageal cancer (4 cases). Results 16 kinds of chemotherapeutic drugs with high sensitivity to lung squamous cell carcinoma were the following:oxaliplatin (60%), cisplatin, cyclophosphamide, paclitaxel (40%). 16 kinds of chemotherapeutic drugs with high sensitivity to lung cancer were the followings:vinorelbine, paclitaxel, fluorouracil (63%). 16 kinds of chemotherapeutic drugs with high sensitivity to esophageal squamous cell carcinoma were the followings:Navelbine, vincristine, topotecan (75%). Conclusion Susceptibility testing of tumor cells in vitro has guiding significance for reasonable choice of breast cancer chemotherapy.

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Analysis of the death causes of patients with hypertensive intracerebral hemorrhage after operation

SONG Chaoyan,XIE Dong,DONG Xiaohui,WANG Chunsheng

Medical Reserch and Education 2014, 31 (2): 25-29. DOI: 10.3969/j.issn.1674-490X.2014.02.007

Abstract （363）

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Objective To explore the effects and inlfuence factors of the patients with hypertensive intracerebral hemorrhage (HICH) after operation and analyze the causes of death after operation. Methods Clinical data of 324 cases with hypertensive intracerebral hemorrhage after operation was analyzed retrospectively, and tried to find out the primary related reasons of death based on the analysis. Results The patient’s consciousness obstructive level when they were admitted into hospital was more severe, the mortality was more higher. The mortality in IV, V level was increased obviously (P<0.01). The mortality was higher in the group that hemorrhage amount was larger. When hemorrhage >80mL, it was significant (P<0.01). The hemorrhage was deeper, the mortality was higher. The mortality increased significantly in the group of thalami and intraventricular hemorrhage (P<0.05). The important factors of the direct cause of death were pernicious intracranial hypertension and pulmonary infection in complications (P<0.01). Conclusion Consciousness obstructive level, regions of hemorrhage, amount of hemorrhage, and complications were important factors that affected the postoperation mortality in patient with hypertensive intracerebral hemorrhage.

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Postoperative analgesia effects of parecoxib sodium preemptive analgesia for abdominal surgery in elderly patients

ZHANG Jinli,YAN Hongli,JIN Xiaoshi

Medical Reserch and Education 2014, 31 (2): 30-32,59. DOI: 10.3969/j.issn.1674-490X.2014.02.008

Abstract （365）

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Objective To investigate parecoxib sodium preemptive analgesia effects of abdominal surgery in elderly patients with postoperative analgesia. Methods ASA I-II class underwent open surgery. 60 cases of elderly patients were randomly divided into observation group and control group, 30 cases in each group. The observation group started 30 min before anesthesia intravenously parecoxib sodium 40 mg, control group at the same time intravenous Saline. Results The postoperative analgesia magnitude improvement in VAS score and VAS was significantly better than the control group; observation group were nausea, sleepiness, dizziness was significantly lower than the control group; patients using the drug reduced postoperative pain remedy were observed. Conclusion Parecoxib sodium preemptive analgesia for postoperative analgesia in elderly patients with abdominal surgery is better, higher security method in relieving pains in clinical practices.

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Clinical observation of aesthetic restoration with unprepared porcelain laminate veneer in front teeth

ZHANG Ling,WANG Qi,ZHANG Wei

Medical Reserch and Education 2014, 31 (2): 33-36. DOI: 10.3969/j.issn.1674-490X.2014.02.009

Abstract （386）

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Objective To observe the clinical effects of aesthetic restoration with unprepared porcelain laminate veneer in front teeth. Methods 100 teeth restored with unprepared Porcelain Laminate Veneer were collected and were examined periodically after 2 years, so as to record the completeness of the restored teeth, the satisfaction of the color and the sensitivity of the target teeth after the bond. Results 6 teeth failed out of the 100 teeth restored with unprepared porcelain laminate veneer. Success rate was 94.0%. Conclusion Unprepared porcelain laminate veneer can be used to treat the defect, space, and the discoloration of the front teeth. Successful clinical results can be achieved. Therefore it is a reliable technique for restoring front teeth aesthetically.

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Study on the determination of serum homocysteine levels in young patients with post-stroke depression

LIU Xiyan,LI Huimin,SHI Fuping,JIANG Ye,ZHANG Qiuping,GAO Tianchu

Medical Reserch and Education 2014, 31 (2): 37-40. DOI: 10.3969/j.issn.1674-490X.2014.02.010

Abstract （325）

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Objective To study the correlation of the serum homocysteine (Hcy) levels and young patients with post-stroke depression. Methods 80 cases of stroke patients (incidence 3 weeks) from 18 to 45 years old were selected who had been diagnosed and were treated from September, 2011 to November, 2013 in the outpatient of our hospital as the subjects of study. Among them, 35 cases with post-stroke depression were in Group A, the left 45 cases with post-stroke depression who had not been occurred in Group B, 35 cases of healthy people served as normal reference group. The serum homocysteine levels between Group A, B and the reference group were compared. According to HAMD score, the severity of depression in Group A were assessed, it was divided into mild depression, moderate depression and severe depression subgroup, then compared the serum homocysteine levels among the three subgroups. Results Compared with normal reference group, Hcy levels of Group A and B were signiifcantly higher, the difference was statistically signiifcant. Hcy levels of the three groups were compared respectively, all of the differences were statistically signiifcant. The Hcy levels of the mild, moderate and severe depression group in Group A were increased with the increase of HAMD score.The degree of depression and homocysteine levels were positively correlated (r=0.7545, P<0.05). Conclusion The occurrence of stroke and post-stroke depression in young adults were related with the Hcy levels of serum, and the higher of the Hcy levels is , the more severe degrees of depression are.

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Clinical observations of Carbamazepine combined with pricking and lfash-ifre cupping in the treatment of postherpetic neuralgia

MA Xiaojuan,ZHANG Weina,LI Heshan,QIE Yongtao

Medical Reserch and Education 2014, 31 (2): 41-44. DOI: 10.3969/j.issn.1674-490X.2014.02.011

Abstract （406）

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Objective To observe the curative effect and safety of pricking and lfash-ifre cupping therapy to cure the postherpetic neuralgia. Methods The 60 cases were divided into two groups:one was the control group, Carbamazepine 100 mg was taken orally by the patients in control group, three times per day. And the 40 cases from the observation group were additionally treated with pricking and lfash-ifre cupping every two days beside Carbamazepine. Two weeks were served as one course of treatment. After ifnished, the curative effects were evaluated using the method of visual analogue scale (VAS), according to the pain and sleeping quality of patients before and after treatment. Results The cure rate in observation group was 87.5%and that of control group was 60.00%. The difference was signiifcant (P<0.05). The pain and the accumulate point of sleeping of patients from both groups were signiifcantly decreased after cure, and the curative effects of tested group was better than that of controls (P<0.5). Conclusion The pain of patients was greatly alleviated with the treatment of Carbamazepine combined with pricking and lfash-ifre cupping, and the life quality of patients can be improved, furthermore the method is easy to perform, and gets a good compliance, has little side-effects, which is a good alternative to cure the postherpetic neuralgia.

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Clinical obserwation on curative effects of Mizolastine combined with the capsule of Runzaozhiyang in the trestment of chronic urticaria

MA Xiaomin,LI Heshan,WEI Yixuan

Medical Reserch and Education 2014, 31 (2): 45-47. DOI: 10.3969/j.issn.1674-490X.2014.02.012

Abstract （388）

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Objective To investigate the clinical effect and safety when Mizolastine was combined with the capsule of Runzaozhiyang to cure the chronic urticarial. Methods The 110 cases were divided into two groups, one was the observation group, Mizolastine and the capsule of Runzaozhiyang were taken orally by the patients from the observation group, and the dose was 10mg once a daily and 4 capsules one time, 3 times per day for Mizolastine and the capsule of Runzaozhiyang, respectively. The other group was the check, 54 cases were only fed with the Mizolastine, the usage and dose was same as that of test group. The observation lasted for 4 weeks continuously and the effect was evaluated based on the clinical symptoms, the decrease exponent of physical sign after one week, two weeks, and four weeks. Results The cure rate in observation group was 92.86%, and the control group was 74.07%. The difference was signiifcant (P<0.05). Conclusion The therapy of Mizolastine combined with the capsule of Runzaozhiyang to cure the chronic urticarial can get a better curative effects and this therapy has a little side-effects and good compliance.

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Application of establishing standard percutaneous nephrolithotomy channel with balloon dilation in the treatment of renal staghorn calculi

LIU Ping,YANG Wenzeng,AN Feng,GU Deqiang,CUI Zhenyu

Medical Reserch and Education 2014, 31 (2): 48-50. DOI: 10.3969/j.issn.1674-490X.2014.02.013

Abstract （336）

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Objective To evaluate the efficacy and safety of balloon dilatation through percutaneous nephroscopic channel establishment in the treatment of renal staghorn calculi. Methods From 2012 August to 2013 August 35 cases of percutaneous renal access were established with the treatment of renal staghorn calculi using balloon dilation to observe the bleeding and channel creation time. Results Percutaneous nephroscopic channels were established successfully in all patients, the average channel establishment time was about 6.5 min. no significant residual stones in 31 patients, stone clearance rate was 88.6%, 4 cases of patients with residual stones, about the size of 0.5-0.7 cm, after extracorporeal shock wave lithotripsy and stone combination drug therapy, after 3 months later, the stones were discharged in all patients, there was no damage to surrounding organs, no blood fransfusion and collection system complications, coninuous follow up for 3-12 months, no complication happened. Conclusion The balloon dilation establishing standard PCNL channel has the advantages of fast, safe, effective, and provides a better treatment for patients with renal staghorn calculi.

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Determination and evaluation of the sanitary quality of non-commercial liquor samples partial circulating in Hebei province

YANG Hongru,HAN Dandan,LIU Yanfei,GAO Wen,ZHANG Bo

Medical Reserch and Education 2014, 31 (2): 51-55. DOI: 10.3969/j.issn.1674-490X.2014.02.014

Abstract （265）

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Objective To understand the status of sanitary quality of non-commercial liquor, and provide scientific basis for health supervision departments, the content of methanol, fusel oil, heavy metals of partial non-commercial liquor samples were detected in Hebei Province. Methods Part of the urban district and county rural were selected as the investigation spots, 65 samples from home-made (19 samples) and bulk liquor (46 samples) were randomly collected for testing. The content of methanol and fusel oil were detected by capillary gas chromatographic column method, and flame atomic absorption spectrometry method was applied in measuring the content of lead, cadmium and manganese. The experimental process and evaluation were referenced to the current national standards. Results 59 of the 65 (90.77%) non-commercial liquor samples are qualiifed in the indicators of methanol. Qualiifed rate of brewed liquor and bulk liquor are 68.42%(13/19) and 100%(46/46) respectively with statistically signiifcant difference (P=0.000). Of the 65 samples, the median content of methanol, fusel oil and alcohol are 0.091 g/L , 0.261 g/L and 45.89%vol respectively. Content of the above three indicates in home-made liquor are (0.470 g/L, 1.513 g/L, 49.00%vol) higher than that of the bulk liquor(0.082 g/L, 0.190 g/L, 44.945%vol) with statistically signiifcant difference (P<0.05). Conclusion Sanitary quality of the Non-commercial liquor can not be ignored in Hebei Province, especially the home-made liquor. Hope relevant departments to strength supervision to ensure the drinker’s health.

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