Table of Content

25 August 2022, Volume 39 Issue 4

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Effect of RG108 on proliferation and gene expression of HT22 cell line

JIANG Le,WANG Xiaobing,HE Ershu,ZHENG Xiaoye,GONG Zhiting

2022, 39(4):  1-7.  DOI: 10.3969/j.issn.1674-490X.2022.04.001

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Objective To investigate the effect of DNA methyltransferase inhibitor RG108,on HT22 cells,a mouse hippocampal neuronal cell line cultured in vitro.Methods HT22 hippocampal neuronal cells cultured in vitro were treated with DNA methyltransferase inhibitor RG108 at concentrations of 0.5,5,and 50 μmol/L,and the cell viability was detected with CCK-8,and the expression of middle and downstream genes in the cells was detected using RT-qPCR.Results CCK-8 assay showed that 50 μmol/L RG108 could promote the proliferation of HT22 cells after 48 and 72 hours and the difference was statistically significant(P<0.05).RT-qPCR results demonstrated that the expression of synaptic plasticity-related genes nr1 and reln decreased in HT22 cells treated with 50 μmol/L RG108,and the difference was statistically significant(P<0.05).Conclusion DNA methyl transferase inhibitor RG108 can promote the proliferation of mouse hippocampal cell line HT22 cells and regulate the expression of neuroplasticity-related genes.Moreover,RG108 may affect synaptic plasticity,which may influence synaptic plasticity-related behaviors such as memory formation.

Advances on pathophysiological mechanism of postoperative delirium in elderly patients

GAO Qi,SUN Tianpei,WU Guangyi

2022, 39(4):  8-13.  DOI: 10.3969/j.issn.1674-490X.2022.04.002

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Postoperative delirium(POD)is characterized by decreased attention,consciousness and cognitive disorders and perceptual disorders.It tends to occur in elderly patients,and is closely related to prolonged hospital stay,increased economic burden,reduced quality of life and increased postoperative mortality.At present,the pathophysiology and pathogenesis of POD have not been fully defined,and there are no effective biological and clinical indicators,which affects the early diagnosis and prevention of POD to a certain extent.This paper reviews the pathogenesis of POD in recent years in order to have a clearer understanding of POD from the physiological mechanism and provide more effective methods for the prevention and treatment of POD in clinic.

Effect of enhanced sensory stimulation-oriented facilitation technique in the rehabilitation of upper limb function after stroke

XIE Ruijuan, DENG Yun, LIU Juan, YANG Nan,ZHANG Kun

2022, 39(4):  14-21.  DOI: 10.3969/j.issn.1674-490X.2022.04.003

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Objective To explore the influence of strengthening facilitation technique guided by sensory stimulation on the rehabilitation effect of upper limb function in stroke patients on occupational therapy. Methods Sixty patients with paraplegia and spasms during stroke that were treated in our department from June 2018 to May 2020 were selected as the subjects of the study. These patients were divided into therapy group(n=30)and control group(n=30). Both groups received routine rehabilitation on this basis. The therapy group were given strenghening facilitation techniques such as Brunnstrom technique, Bobath technique, Rood technique, PNF(propriceptive neuromuscular facilitation)technique, especially strengthening the application of the sense of stimulation ingredients to stimulate multi-sensory paths such as visual hearing, shallow sensations, ontogenal sensations, composite sensations and by password, brushing, tapping, pressing, extrusion, stretching, cold water, warm water, resistance, control and other measures, the treatment period was 12 weeks. Fugl-Meyer Assessmont Scnle(FMA)-upper limb was used to examine the rate the motor function of 2 groups of patients before and 6 weeks and 12 weeks after treatment. Ability of ADL(activities of daily living)was scored in 2 groups of patients before and 6 weeks and 12 weeks after treatment using an improved Barthel index scale(modified Barthel index, MBI). In strumental ADL ability 2 groups half a year after discharge using Functional Activity Questionnaires(FAQ), the Brunnstrom stage was used to determine the rate the proportion of partial separation exercise period and separation exercise period at 12 weeks of treatment in 2 groups. Results 2 groups after 6 weeks and 12 weeks had significant effects compared to pre-treatment,and the exercise ability and ADL ability of the therapy group were better than that of the control group, the exercise ability and ADL ability of the two groups after 12 weeks were better than those of the group after 6 weeks(all P<0.01). In strumental ADL ability of the therapy group was better than that of the control group(P<0.01). In 2 groups half a year after discharge, there were significantly more cases of patients with upper limb movement function recovery up to Brunnstrom 4 and above treatment group than in 2 groups(all P<0.01), it was shown that strengthening sensory stimulation in rehabilitation training could enable the patients to obtain better rehabilitation results. Conclusion The use of facilitation technique in occupational therapy, especially the strengthening of the sensational stimulation component of facilitation technique, can significantly promote the process of motor function rehabilitation in patients with paraplegia with stroke paraplegia, significantly improve the movement function of the upper limbs of patients, and improve ADL ability.

Development on digital orthopedic technology in clinical work

YANG Xuping, LI Xingyong

2022, 39(4):  22-29.  DOI: 10.3969/j.issn.1674-490X.2022.04.004

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Digital medicine is an emerging discipline that combines scientific informatics with medical technology, including 3D printing, finite element analysis and computer-aided orthopedic technology, and its application in the field of orthopedics is very extensive. Based on the many advantages of digital orthopedic technology in clinical work, it helps to solve the difficulties encountered in clinical work and has considerable application prospects, and its effective application in the clinic can benefit the majority of patients.

Advances on artificial intelligence in the diagnosis and treatment of urinary calculi

ZHAN Xiaofei, CUI Zhenyu, ZHAO Chunli

2022, 39(4):  30-38.  DOI: 10.3969/j.issn.1674-490X.2022.04.005

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As healthcare systems continue to digitize and medical data continue to increase, clinicians face significant challenges in making accurate diagnoses, developing personalized treatment plans, and determining prognoses. There are some problems such as unknown formation factors, complex components, and large anatomical differences in the occurrence sites of urinary calculi, which hinder the personalized diagnosis and treatment of patients with calculi. Artificial intelligence can flexibly analyze and learn different data types, providing new ideas for the accurate diagnosis and treatment of urinary calculi. This paper reviews the research content of artificial intelligence in the diagnosis and treatment of urinary calculi to improve the understanding of the application of artificial intelligence in the diagnosis and treatment of urinary calculi.

Developments on telemedicine in management of senile hypertension

HUANG Shengnan,ZHAO Rui,XIAO Nuan

2022, 39(4):  39-44.  DOI: 10.3969/j.issn.1674-490X.2022.04.006

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Essential hypertension is one of the most common chronic diseases in the elderly, and it is also the most common risk factor of acute cardiovascular and cerebrovascular diseases.As a new hypertension management model, telemedicine plays an important role in medication compliance and hypertension control rate of patients with hypertension.This paper summarizes telemedicine and its concept in the management of senile hypertension, the application status of telemedicine in the management of senile hypertension and the suggestions to speed up the development of telemedicine management model.

HAO's clinical experience of traditional Chinese medicine in Baoding in ophthalmology

MENG Hongwei

2022, 39(4):  45-54.  DOI: 10.3969/j.issn.1674-490X.2022.04.007

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HAO's ophthalmology of traditional Chinese Medicine(TCM)is the specialty of TCM in Baoding. HAO Dexin is a renowned Chinese ophthalmologist at the Hebei Institute of Traditional Chinese Medicine in Baoding in ancestral ophthalmology.HAO is a representative of traditional Chinese medicine ophthalmology.He has rich experience in diagnosis and treatment of diseases such as fulminant blindness, myopia and fundus oculi diseases.The curative effect is remarkable.HAO is good at treating eye diseases with traditional Chinese medicine and acupuncture.He has unique experience in the application of Chinese medicine prescription and the manipulation of acupoints.The diagnosis and treatment of ophthalmologic diseases should be based on the three Jing of Xin,Gan and Shen.

Qualitative research on learning experience of medical students' professional accomplishment education based on palliative medicine

CUI Meng,LI Na,WANG Yumei

2022, 39(4):  55-60.  DOI: 10.3969/j.issn.1674-490X.2022.04.008

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Objective To explore the learning experience of medical students on the teaching mode of professional accomplishment education based on palliative medicine.Methods The semi-structured interview method was adopted to interview 12 medical undergraduates who participated in this course.The data were analyzed with Colaizzi 7-step analysis method.Results Five themes were extracted from the learning experience of medical students,namely,enhanced altruism;enhanced professional values;increasing knowledge and learning ability;improving recognition of the concept of death and developing empathy ability.Conclusion The professional accomplishment education based on palliative medicine is beneficial to improve medical students' professional values,enhance their learning ability and initiative,then improve their professional accomplishment.

Application of scene introduction combined with case-based learning model in anesthesiology teaching

WEI Fusheng, YE Lingling, HUANG Yuanlu, MA Longxian, YANG Lei

2022, 39(4):  61-65.  DOI: 10.3969/j.issn.1674-490X.2022.04.009

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Objective To explore the effect of scene introduction strategy combined with case-based leaning(CBL)in anesthesiology teaching.Methods The undergraduate students majoring in anesthesiology in Nanchang University were randomly divided into control group and observation group according to the random number table method.The control group(26 students)was taught by the CBL,and the observation group(27 students)was taught by the scene introduction strategy combined with the CBL.And the class room test was conducted after each class.At the end of the semester,the scores of the two groups in theoretical test,experimental test and classroom test were compared,and a questionnaire survey was conducted according to the students' satisfaction with the teaching effect.Results The scores of the observation group in classroom test,theoretical test and experimental test were significantly higher than those of the control group,the difference was statistically significant(P<0.05).The questionnaire survey showed that the satisfaction rate of the observation group was significantly higher than that of the control group in improving academic performance,stimulating learning interest,promoting active learning,improving learning efficiency and students' satisfaction with teaching methods,with statistical significance(P<0.05).The questionnaire survey showed that the satisfaction rate of students in the observation group was significantly higher than that in the control group(P<0.05).Conclusion The application of the scene introduction strategy combined with the CBL in clinical anesthesiology teaching can significantly improve the theoretical level and clinical practice ability of anesthesia students.The application of this mode in anesthesiology teaching has achieved good teaching results,which is worthy of popularization and application in teaching.

The application of formative evaluation and case-based learning in practice teaching of laboratory medicine technology

WANG Dongping,WU Yang,WEI Lianhua,YAN Li,LI Keke,YE Hua,LI Shaohua,SUN Yanqing

2022, 39(4):  66-72.  DOI: 10.3969/j.issn.1674-490X.2022.04.010

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Objective To explore the practice and effect of the combined application of formative evaluation and case-based learning(CBL)in the clinical education of laboratory medicine technology. Methods A total of 135 laboratory interns were randomly divided into three groups(group A, group B and group C). Group A:summative evaluation+lecture-based learning. group B: summative evaluation+ CBL. group C: formative evaluation+CBL. The teaching quality of the three groups was evaluated from two aspects of teaching content assessment and teaching effect questionnaire survey. Results The total score and theoretical score in group B and group C were higher than those in group A, and the difference was statistically significant(P<0.05).Conclusion The combination of formative evaluation and CBL can stimulate their interest in learning,cultivate students' ability to think and solve problems independently, increase teaching flexibility, arouse students' enthusiasm for learning,improve the teaching quality, and is suitable for clinical teaching.

Construction of curriculum system of rehabilitation treatment technology specialty based on post standard

LI Ruiming, DUAN Kaixuan, CUI Dandan, GUO Yu

2022, 39(4):  73-80.  DOI: 10.3969/j.issn.1674-490X.2022.04.011

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The curriculum system is the basic guarantee for the quality of talent training. The post standard has the dual effect of testing the quality of talent training and talent employment screening.At present, the curriculum system of rehabilitation technology specialty in China is not consistent enough, which restricts the realization of talent training objectives and specifications, and affects the efficient implementation of healthy China strategy.The basic premise of ensuring the quality of talent training is to reconstruct the curriculum system of rehabilitation technology specialty, reorganize the teaching content and compile integrated teaching materials according to the post standards of rehabilitation treatment.