Table of Content

25 December 2025, Volume 42 Issue 6

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Advances on ferroptosis in hematological malignancies

WU Ting,ZHOU Yue

2025, 42(6):  1-14.  DOI: 10.3969/j.issn.1674-490X.2025.06.001

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Hematological malignancies are a group of heterogeneous diseases originating from the hematopoietic and lymphatic systems, characterized fundamentally by malignant clonal proliferation and differentiation arrest. Clinically, there are often significant challenges of poor prognosis and high risk of recurrence. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has been confirmed to be closely related to the pathogenesis, progression, and therapeutic response of hematological malignancies. This article systematically reviews the molecular mechanisms of ferroptosis. It focuses on the research developments of hematological malignancies represented by leukemia, multiple myeloma, myelodysplastic syndromes, and lymphoma through the regulation of ferroptosis-related genes and pathways in order to provide a theoretical foundation for a deeper understanding of the disease process and the development of targeted treatment strategies.

Latest treatment progress of heart failure

ZHAO Yang, CHEN Siji, LIN Shuwu

2025, 42(6):  15-25.  DOI: 10.3969/j.issn.1674-490X.2025.06.002

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Heart failure is a syndrome characterized by impaired ventricular filling and/or ejection function, often caused by various cardiac structures or functional impairments. The cardiac output cannot meet the metabolic needs of body tissues, resulting in pulmonary and/or systemic congestion, as well as inadequate blood perfusion to organs and tissues. Heart failure affects approximately 64 million people worldwide. In recent years, significant progress has been made in the treatment of heart failure in various fields such as internal and external medicine, from the “Golden Triangle” to the “New Four Links” and then to the “Five Golden Flowers”. From “heart transplantation” to “cardiac resynchronization therapy” and then to “left ventricular assist device”. By referring to existing clinical research and practice, we mainly summarize effective measures for the prevention and treatment of heart failure(mainly chronic heart failure), providing reference for clinical doctors.

Correlation between radiographic changes and clinical outcomes after supramalleolar osteotomy for varus ankle osteoarthritis

DUO Wanfa, LI Hua

2025, 42(6):  26-33.  DOI: 10.3969/j.issn.1674-490X.2025.06.003

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Objective To investigate the correlation between radiographic changes and clinical outcomes after supramalleolar osteotomy(SMOT)for varus ankle osteoarthritis(AA). Methods A retrospective analysis was conducted on 23 patients(24 feet)with varus AA treated with SMOT between January 2019 and August 2023. There were 9 males(9 feet)and 14 females(15 feet), with a mean age of 57.94 years. Radiographic parameters were compared preoperatively and at final follow-up. Clinical outcomes were assessed using the American Orthopedic Foot and Ankle Society(AOFAS)score and Visual Analogue Scale(VAS)for pain. Correlations between radiographic parameters and AOFAS/VAS scores, as well as between changes in radiographic parameters and final scores, were analyzed. Results The mean follow-up was 15.25±3.07 months. All radiographic parameters, AOFAS, and VAS scores showed significant improvement postoperatively(P<0.01). The mean AOFAS score were improved to 81.31±2.73, and VAS decreased to 1.93±0.29. Pearson analysis revealed that medial clear space(MCS)was significantly correlated with AOFAS and VAS scores both preoperatively and at final follow-up(P<0.05). Changes in tibial articular surface angle(TAS)and MCS were significantly correlated with clinical outcomes(P<0.01). Conclusion SMOT provides satisfactory mid-term outcomes for varus AA. Changes in TAS and MCS are important indicators for evaluating clinical efficacy, with greater changes associated with better outcomes.

Identification and characterization of SNP and InDel variants in Scutellaria baicalensis Georgi transcriptom

SUN Zhichao,ZHAO Chunying,LU Yang,XIE Yan,WANG Hui,GAO Yanxia

2025, 42(6):  34-40.  DOI: 10.3969/j.issn.1674-490X.2025.06.004

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Objective To develop specific molecular markers of Scutellaria baicalensis and perform genetic diversity analysis and molecular marker-assisted breeding. Methods Single nucleotide polymorphisms(SNP)and insertion and deletion polymorphisms(InDel)sites in the transcriptome of flowers and roots of Scutellaria baicalensis were analyzed. Results The results showed that an average of 216 067 SNPs were found in the transcriptome of 18 skullcap flowers and roots, and the ratio of conversion to transversion was 1.42~1.61, and the number of loci distributed in the exome region was the largest, and the number of loci with missense mutations was the largest. The average number of InDel loci in each sample was 22 864, and the number of insertion loci was greater than that of the deletion type, which was the most distributed in the gene and had the most frameshift insertions. Conclusion The results show that the transcriptome of the flowers and roots of Scutellaria baicalensis is rich in SNPs and InDel loci, and has high polymorphisms, which provides data support for the development of specific molecular markers in Scutellaria baicalensis.

Analysis of current situation and influencing factors of communication ability between nursing undergraduates and the elderly

WANG Ruofan, WANG Shanshan, YU Wanchen, XIE Xin, GAO Hangjin

2025, 42(6):  41-49.  DOI: 10.3969/j.issn.1674-490X.2025.06.005

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Objective To investigate the current status of communication competence between undergraduate nursing students and the elderly and analyze the influencing factors. Methods A total of 364 nursing undergraduates from a medical college in Tianjin were selected by stratified sampling from December 2024 to January 2025. General information questionnaire, Self-Rating Scale of Communication Competence between Nursing Students and the Elderly, Extraversion-Introversion Personality Scale, and Emotional Intelligence Scale were used for the survey. Multiple linear regression analysis was adopted to identify the influencing factors of communication competence between nursing undergraduates and the elderly. Results The communication competence score of 364 undergraduate nursing students with the elderly was 80.05±8.43. The communication competence was positively correlated with the total score of emotional intelligence(P<0.01). Multiple linear regression analysis showed that whether having studied communication skills courses, personality traits, and emotional intelligence were the influencing factors of communication competence between undergraduate nursing students and the elderly(P<0.05), explaining 20.30% of the total variance. Conclusion The communication competence of nursing undergraduates with the elderly is at a medium to high level. Nursing educators should first clarify the relevant influencing factors of this competence, and then adopt appropriate intervention methods to further improve nursing students' communication ability with the elderly group.

Mediating effect of loneliness between social constraints and depression in breast cancer patients

CAO Longnü, CUI Hongquan, WANG Yinling

2025, 42(6):  50-56.  DOI: 10.3969/j.issn.1674-490X.2025.06.006

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Objective To investigate the mediating effect of loneliness on the relationship between social constraints and depression in breast cancer patients and inform the reduction of the incidence of depression in breast cancer patients. Methods Data were collected from 257 breast cancer patients at a hospital in Jiangsu province using three scales: the Patient Health Depression Questionnaire, Social Constraints Scale, and Cancer Loneliness Scale. General information was then analyzed. Results Depression, social constraints and loneliness scores of breast cancer patients were 6.63±3.15, 30.71±7.73 and 21.24±5.21 respectively. Depression was positively connected to social constraints and loneliness, and social constraints was positively connected to loneliness(r=0.498,r=0.396,r=0.639, all P<0.01). The loneliness of breast cancer patients has a partial mediating effect between social constraints and depression, with the mediating effect making up 27.15% of the total effect. Conclusion Medical workers should take measures to reduce the social constraints of breast cancer patients and reduce the loneliness so as to reduce the occurrence of depression.

Advances on multimodal analgesia management after skin flap repair

WU Hexiang, DI Tietao,JIANG Yuan,ZHANG Chunling,CHEN Lu,PAN Yao

2025, 42(6):  57-63.  DOI: 10.3969/j.issn.1674-490X.2025.06.007

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The postoperative pain of skin flap repair is severe,prolonged duration and complex mechanism,which affects the rehabilitation and quality of life of patients. Single analgesic method is often difficult to meet the clinical needs. Multimodal analgesia management integrates the advantages of different intervention methods and accurately acts on the pain conduction pathway,which has become a research hotspot. This paper reviews the mechanism of postoperative pain,multimodal analgesia management strategy and self-pain management of patients,and analyzes the advantages and disadvantages of different analgesia strategies and clinical application effects,so as to provide reference for medical workers in order to improve the effect of pain management through doctor-patient cooperation.

Effect of different health education methods on fall vigilance of elderly inpatients

WANG Zheng, BI Zhaoyu, ZHU Fei, SONG Yanyan, ZHANG Shumin, LIU Juan, GAO Yuan, CHEN Xi

2025, 42(6):  64-72.  DOI: 10.3969/j.issn.1674-490X.2025.06.008

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Objective To explore the application effect of routine education, gain-based framework healtheducation and loss-based framework health education in fall prevention of hospitalized elderly patients. Methods Ninety-six elderly patients who were hospitalized in the Department of Neurology and Rehabilitation Ward of a tertiary hospital in Baoding city from July to August 2025 were selected as study subjects. The subjects were divided into three groups: the control group implemented conventional health education; to further clarify the impacts of the gain framework and loss framework, the intervention group was divided into the gain-framing group and the loss-framing group. The gain framework group added gain framework theory-guided health education on a conventional basis; and the loss framework group combined loss framework theory intervention on a conventional basis, comparing the fall alertness and fall self-efficacy scores of patients in the three groups before and after the intervention. There were 2 cases of loss of visits in the control group and 1 case of loss of visits in the loss framework group during the intervention period. Results Falls alertness was significantly increased in all three groups of patients after the intervention compared with the pre-intervention period(P<0.05), in which the alertness and falls self-efficacy scores were higher in the gain-framing group and loss-framing group than in the control group, with statistically significant differences(P<0.05), and the loss-framing group was better than that of the gain-framing group in improving falls alertness and self-efficacy, with statistically significant differences(P<0.05). Conclusion The health education program designed based on the theory of information frame effect can effectively enhance the fall prevention awareness and self-management ability of elderly inpatients, and the loss frame-oriented intervention strategy is more advantageous.

Research on the delicacy management model of the second classroom for emergency medicine professional master's degree programs

JIANG Min, YAN Ping, CHEN Shaoying, CAO Zanfeng, KUANG Suhua, LIANG Zijing, LIANG Qing

2025, 42(6):  73-80.  DOI: 10.3969/j.issn.1674-490X.2025.06.009

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Objective In response to the numerous drawbacks of the current “parallel training” model for professional master's degree(specialized master's)education, a more scientific and effective second classroom training system for emergency medicine master's students has been constructed to comprehensively and rapidly enhance the core competencies required for advanced applied professionals. Methods This study developed a systematic second classroom training program and explored its implementation through a delicacy management teaching model among 24 emergency medicine professional master's students from the classes of 2020-2023 at the First Affiliated Hospital of Guangzhou Medical University. Results During the training period, the competency of emergency medicine master's students significantly improved across the board, with student satisfaction reaching 91.66% and instructor satisfaction as high as 97.14%.Conclusion Practice has demonstrated that the integration of the second classroom, systematic training, and delicacy management into the education of emergency medicine master's students has high practical value.