医学研究与教育 ›› 2015, Vol. 32 ›› Issue (4): 24-28.DOI: 10.3969/j.issn.1674-490X.2015.04.007

• 疾病预防与控制 • 上一篇    下一篇

系统性红斑狼疮患者治疗结局影响因素分析

张红杰1,畅晋1,陈萌2,黄帅帅1,许鸣华2   

  1. 1. 河北大学公共卫生学院,河北 保定 071000;2. 河北大学附属医院,河北 保定 071000
  • 出版日期:2015-08-25 发布日期:2015-08-25
  • 通讯作者: 许鸣华(1970—),女,河北清苑人,主任医师,硕士,从事风湿免疫疾病的临床和科研工作。 E-mial: xuminghua6616@163.com
  • 作者简介:张红杰(1966—),女,河北保定人,教授,硕士,主要从事慢性病防治教学和科研工作。

Analysis on the influencing factors of treatment outcome of systemic lupus erythematosus

ZHANG Hongjie1, CHANG Jin1, CHEN Meng2, HUANG Shuaishuai1, XU Minghua2   

  1. 1. Department of Health Statistics, Institute of Public Health, Hebei University, Baoding 071000, China; 2. Department of Rheumatology, Affiliated Hospital of Hebei University, Baoding 071000, China
  • Online:2015-08-25 Published:2015-08-25

摘要: 目的 探讨影响系统性红斑狼疮 (SLE) 治疗结局的因素。方法 收集某综合医院风湿免疫科 2010 年至 2013 年 系统性红斑狼疮患者病历资料,分析系统性红斑狼疮治疗结局的影响因素。结果 共分析 350 份 SLE 病历资料。单 因素分析显示中老年(≥45 岁)患者、C 反应蛋白升高、C3 降低、起病重或危重、SLE 复发者治疗结局较差。多 因素 logistic 回归分析显示,年龄和是否复发是 SLE 患者治疗结局的独立影响因素,OR 值分别为 2.017 和 2.517。 结论 中老年患者、SLE 复发患者的治疗结局较差,应在临床治疗时给予重视。

关键词: 系统性红斑狼疮, 治疗结局, 影响因素

Abstract: Objective To explore the influencing factors of treatment outcome of SLE. Methods Data about the patients with SLE was collected by copying the information from the medical records during 2010 to 2013 in a comprehensive hospital, and the influencing factors of treatment outcome of SLE were analyzed. Results 350 medical records were collected. Univariate analysis showed that patients with middle-and-old, positive C-reactive protein, C3 decreased, serious disease and relapsed patients had a poor outcome. Multivariate Logistic regression analysis showed that age and whether relapse were independent influencing factors of treatment outcome in patients with SLE, OR were 2.017 and 2.517 respectively. Conclusion The treatment outcome of elderly patients (≥45 years old) and relapsed patients was poor, and more attention should be given while clinical treatment.

Key words: SLE, treatment outcome, influencing factors