急性脑梗死患者血清胆红素、同型半胱氨酸与颈动脉粥样硬化斑块性质的关系

doi:10.3969/j.issn.1674-490X.2019.01.003

医学研究与教育 ›› 2019, Vol. 36 ›› Issue (1): 13-16.DOI: 10.3969/j.issn.1674-490X.2019.01.003

急性脑梗死患者血清胆红素、同型半胱氨酸与颈动脉粥样硬化斑块性质的关系

李蒙蒙¹,朱明肃¹,李轩²,冯锐²,王佩²

1.承德医学院研究生学院, 河北承德 067000;
2.保定市第一中心医院神经内科, 河北保定 071000

收稿日期:2018-07-13 出版日期:2019-02-25 发布日期:2019-02-25
通讯作者: 王佩(1971—),女,河北保定人,主任医师,博士,硕士生导师,主要从事脑血管病、癫痫、帕金森氏病等疾病的临床研究。E-mail: w_z_h_01@163.com
作者简介:李蒙蒙(1991—),女,河北保定人,医师,在读硕士,主要从事脑血管病的临床研究。 E-mail: 425735833@qq.com

Received:2018-07-13 Online:2019-02-25 Published:2019-02-25

摘要/Abstract

摘要： 目的探讨急性脑梗死患者血清胆红素、同型半胱氨酸(homocysteine,Hcy)水平与颈动脉粥样硬化斑块稳定性的相关性。方法选取急性脑梗死患者192例,于入院次日清晨空腹采集外周静脉血,采用化学氧化法检测血清胆红素、荧光偏振免疫法检测血Hcy 水平。应用 IU-22彩色多普勒超声诊断仪测定两组颈动脉内膜中层厚度(IMT),探究急性脑梗死患者血清胆红素、Hcy 水平与颈动脉粥样硬化斑块稳定性的相关性。结果易损斑块组血清胆红素(尤其是直接胆红素)显著低于稳定斑块组(P<0.05),易损斑块组Hcy水平显著高于稳定斑块组(P<0.05)。结论急性脑梗死患者颈动脉粥样硬化斑块稳定性在一定范围内可能与血Hcy 水平呈负相关,与血清总胆红素、直接胆红素水平呈正相关。

关键词: 急性脑梗死, 胆红素, 同型半胱氨酸, 颈动脉粥样硬化斑块, 稳定性

Abstract: Objective To investigate the correlation between serum bilirubin and homocysteine(Hcy)and the stability of carotid atherosclerotic plaques in patients with acute cerebral infarction. Methods 192 patients with acute ischemic stroke were selected to collect peripheral venous blood on the second early morning in the hospital. The serum bilirubin were detected by chemical oxidation and Hcy were detected by fluorescence polarization immunoassay. Two groups of carotid artery intima-media thickness(IMT)were measured by IU-22 color Doppler ultrasonography, and the correlation of serum bilirubin and Hcy levels with carotid atherosclerotic plaques in patients with acute cerebral infarction was analyzed. Results The serum bilirubin(especially direct bilirubin)in vulnerable plaque group was significantly lower than that of the stable plaque group(P <0.05), and the level of Hcy in vulnerable plaque group was significantly higher than that of the stable plaque group(P < 0.05). Conclusion The stability of carotid atherosclerotic plaque in patients with acute cerebral infarction may be negatively correlated with the level of blood Hcy, and is positively correlated with the level of serum total bilirubin and direct bilirubin to some degree.

Key words: acute cerebral infarction, bilirubin, homocysteine, carotid atherosclerotic plaques, stability

中图分类号:

R743.3

李蒙蒙,朱明肃,李轩,冯锐,王佩. 急性脑梗死患者血清胆红素、同型半胱氨酸与颈动脉粥样硬化斑块性质的关系[J]. 医学研究与教育, 2019, 36(1): 13-16.

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急性脑梗死患者血清胆红素、同型半胱氨酸与颈动脉粥样硬化斑块性质的关系

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