miR-30a的表达与上皮性卵巢癌患者预后的关系

doi:10.3969/j.issn.1674-490X.2019.02.003

医学研究与教育 ›› 2019, Vol. 36 ›› Issue (2): 13-16.DOI: 10.3969/j.issn.1674-490X.2019.02.003

miR-30a的表达与上皮性卵巢癌患者预后的关系

王伟明¹,刘金¹,张惠¹,解丹¹,刘辉²

1.河北大学附属医院妇产科, 河北保定 071000;
2.河北大学公共卫生学院, 河北保定 071000

收稿日期:2018-12-06 出版日期:2019-04-25 发布日期:2019-04-25
通讯作者: 刘辉(1978—),男,河北安国人,讲师,硕士,主要从事肿瘤流行病学研究。E-mail: liuhui@hbu.cn
作者简介:王伟明(1977—),女,河北定州人,副主任医师,硕士,主要从事妇产科学研究。通信作者:刘辉(1978—),男,河北安国人,讲师,硕士,主要从事肿瘤流行病学研究。 E-mail: liuhui@hbu.cn
基金资助:
国家自然科学基金面上项目(21778013)

Received:2018-12-06 Online:2019-04-25 Published:2019-04-25

摘要/Abstract

摘要： 目的探讨miR-30a在上皮性卵巢癌患者中的表达及其与预后的关系。方法采用实时荧光定量PCR法检测139例上皮性卵巢癌患者组织中miR-30a的表达水平,绘制生存曲线并进行生存分析,探讨其与卵巢癌患者预后的关系。结果卵巢癌患者组织中miR-30a的表达较癌旁组织升高(P<0.05)。miR-30a的高表达与低分化的组织学分期、发生淋巴结转移、发生腹膜转移和较差的FIGO分期(P<0.05)有关。生存分析发现miR-30a高表达患者生存期较短;多因素分析提示miR-30a高表达是卵巢癌的独立预后因素,HR为2.702。结论 miR-30a的高表达是上皮性卵巢癌独立的预后因素,miR-30a可能成为卵巢癌新的诊断和预后标志物。

关键词: miR-30a, 上皮性卵巢癌, 表达, 预后

Abstract: Objective To investigate the miR-30a expression in epithelial ovarian cancer(EOC)and its relationship with the clinicopathological features and prognosis. Methods The miR-30a expressions in 139 cases of EOC tissues were detected with RT-PCR assay. The correlations between miR-30a expressions and clinicopathological features of EOC were analyzed. Survival curves for patients with different miR-30a expressions were plotted using the Kaplan-Meier method and compared using the log-rank test. Results The miR-30a expressions elevated significantly in EOC tissues compared with that in adjacent normal tissues(P<0.05). High miR-30a expressions significantly correlated with lower histological grade, lymph node metastasis, peritoneal metastasis and higher FIGO stage(P<0.05). Kaplan-Meier analysis with log-rank test revealed that high miR-30a expressions were correlated with short survival time of patients with EOC. Multivariate analysis showed that miR-30a expressions were an independent rognostic factor for the overall survival, HR=2.702. Conclusion The miR-30a expression is an independent prognostic factor of patients with EOC,which can serve as a diagnostic and prognostic marker in clinical practice.

Key words: miR-30a, epithelial ovarian cancer, expression, prognosis

中图分类号:

王伟明,刘金,张惠,解丹,刘辉. miR-30a的表达与上皮性卵巢癌患者预后的关系[J]. 医学研究与教育, 2019, 36(2): 13-16.

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miR-30a的表达与上皮性卵巢癌患者预后的关系

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