Association between CHI3L1 expression levels and four cardiovascular diseases: a two-sample Mendelian randomization study

doi:10.3969/j.issn.1674-490X.2026.01.002

Abstract

Abstract: Objective To investigate whether there is a causal relationship between Chitinase-3-like protein 1(CHI3L1)and four cardiovascular diseases(hypertensive heart disease, heart failure, coronary artery disease, myocardial infarction). Methods This study employed a two-sample Mendelian randomization approach, using inverse-variance weighted, weighted median, and MR-Egger methods for effect estimation. Results All analytical methods showed that there was no significant genetic evidences supporting a causal role of CHI3L1 in the four cardiovascular diseases(P>0.05). Conclusion This study does not provide that genetic evidences could result in a causal role of CHI3L1 in the development of cardiovascular diseases.

Key words: Mendelian randomization, Chitinase-3-like protein 1, cardiovascular disease, heart failure, myocardial infarction

CLC Number:

R541
R543

WANG Yijiao, LI Xiaoshan, DUAN Zesen, CAO Mengyun, ZHANG Junling. Association between CHI3L1 expression levels and four cardiovascular diseases: a two-sample Mendelian randomization study[J]. Journal of Hebei Medical College for Continuing Education, 2026, 43(1): 11-19.

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