doi:10.3969/j.issn.1674-490X.2018.06.002

Abstract

Abstract: Gastroesophageal reflux disease(GERD)is a common disease of the digestive system. Although the main symptoms are in the esophagus, it can also have other clinical presentations of multiple systems. More and more studies have shown that GERD is related to lung diseases. This article summarizes the current status of studies on the mechanism between GERD and chronic obstructive pulmonary disease, pneumonia, idiopathic pulmonary fibrosis, gastroesophageal reflux cough, asthma and lung transplantation at home and abroad.

Key words: gastroesophageal reflux disease, pulmonary disease, pathogenesis

CLC Number:

References

[1] 中华医学会病理学分会消化疾病学组筹备组. 胃食管反流病、Barrett 食管和食管胃交界腺癌病理诊断共识[J]. 中华病理学杂志, 2017, 46(2): 79-83.
[2] LEE A L, GOLDSTEIN R S. Gastroesophageal reflux disease in COPD: links and risks[J]. Int J Chron Obstruct Pulmon Dis, 2015, 10: 1935-1949.
[3] BONACIN D, FABIJANI D, RADI M, et al. Gastroesophageal reflux disease and pulmonary function: a potential role of the dead space extension[J]. Med Sci Monit, 2012, 18(5): CR271-CR275.
[4] SAKAE T M, PIZZICHINI M M, TEIXEIRA P J, et al. Exacerbations of COPD and symptoms of gastroesophageal reflux: a systematic review and meta-analysis[J]. J Bras Pneumol, 2013, 39(3): 259-271.
[5] AJMERA M, RAVAL A D, SHEN C, et al. Explaining the increased health care expenditures associated with gastroesophageal reflux disease among elderly Medicare beneficiaries with chronic obstructive pulmonary disease: a cost-decomposition analysis[J]. Int J Chron Obstruct Pulmon Dis, 2014, 9: 339-348.
[6] KIM J, LEE J H, KIM Y, et al. Association between chronic obstructive pulmonary disease and gastroesophageal reflux disease: a national cross-sectional cohort study[J]. BMC Pulm Med, 2013, 13: 51.
[7] RAVELLI A M, PANAROTTO M B, VERDONI L, et al. Pulmonary aspiration shown by scintigraphy in gastroesophageal reflux-related respiratory disease[J]. Chest, 2006,130(5): 1520-1526.
[8] IRWIN R S. Chronic cough due to gastroesophageal reflux disease: ACCP evidence-based clinical practice guidelines[J]. Chest, 2006, 129(1 Suppl): S80-S94.
[9] VAKIL N. Acid inhibition and infections outside the gastrointestinal tract[J]. Am J Gastroenterol, 2009, 104(Suppl 2): S17-S20.
[10] AYBAY C, IMIR T, OKUR H. The effect of omeprazole on human natural killer cell activity[J]. Gen Pharmacol, 1995, 26(6): 1413-1418.
[11] SCARINGI L, CORNACCHIONE P, FETTUCCIARI K, et al. Activity inhibition of cytolytic lymphocytes by omeprazole[J]. Scand J Immunol, 1996, 44(3): 204-214.
[12] YOSHIDA N, YOSHIKAWA T, TANAKA Y, et al. A new mechanism for anti-inflammatory actions of proton pump inhibitors-inhibitory effects on neutrophil-endothelial cell interactions[J]. Aliment Pharmacol Ther, 2000, 14(Suppl 1): 74-81.
[13] 叶俏. 特发性肺纤维化与胃食管反流的研究进展[J]. 慢性病学杂志, 2015, 16(1): 39-43.
[14] SHIMAZU R, AOKI S, KURATOMI Y. Experimental pulmonary fibrosis in rats with chronic gastric acid reflux esophagitis[J]. Auris Nasus Larynx, 2015, 42(5): 382-384.
[15] RAGHU G, MEYER K C. Silent gastro-oesophageal reflux and microaspiration in IPF: mounting evidence for anti-reflux therapy[J]. Eur Respir J, 2012,39(2): 242-245.
[16] KING C, NATHAN S D. Identification and treatment of comorbidities in idiopathic pulmonary fibrosis and other fibrotic lung diseases[J]. Curr Opin Pulm Med, 2013,19(5): 466-473.
[17] 陈碧, 蒋捍东. 胃食管反流病与特发性肺纤维化[J]. 中华结核和呼吸杂志, 2016,39(2): 137-139.
[18] LEE J S, COLLARD H R, ANSTROM K J, et al. Anti-acid treatment and disease progression in idiopathic pulmonary fibrosis: an analysis of data from three randomised controlled trials[J]. Lancet Respir Med, 2013,1(5): 369-376.
[19] LEE J S, RYU J H, ELICKER B M, et al. Gastroesophageal reflux therapy is associated with longer survival in patients with idiopathic pulmonary fibrosis[J]. Am J Respir Crit Care Med, 2011,184(12): 1390-1394.
[20] 姚东英, 刘菲. 胃食管反流病与慢性咳嗽的关系[J]. 国际消化病杂志, 2011,31(4): 201-203.
[21] 弓三东, 崔立红. 胃食管反流性咳嗽发病机制的研究进展[J]. 世界华人消化杂志, 2014,22(19): 2665-2670.
[22] SMITH J A, DECALMER S, KELSALL A, et al. Acoustic cough-reflux associations in chronic cough: potential triggers and mechanisms[J]. Gastroenterology, 2010,139(3): 754-762.
[23] ATES F, VAEZI M F. Insight into the relationship between gastroesophageal reflux disease and asthma[J]. Gastroenterol Hepatol(N Y), 2014,10(11): 729-736.
[24] HERSHCOVICI T, JHA L K, GADAM R, et al. The relationship between type 2 diabetes mellitus and failure to proton pump inhibitor treatment in gastroesophageal reflux disease[J]. J Clin Gastroenterol, 2012,46(8): 662-668.
[25] ARAS G, KANMAZ D, KADAKAL F, et al. Gastroesophageal reflux disease in our asthma patients: the presence of dysphagia can influence pulmonary function[J]. Multidiscip Respir Med, 2012,7(1): 53.
[26] 刘教春, 郑林, 詹志刚, 等. 24h动态PH监测在支气管哮喘合并胃食管反流病的临床研究[J]. 临床肺科杂志, 2016,21(09): 1642-1646.
[27] 朱莎, 李芳. 胃食管反流源性哮喘发病机制的研究现状[J]. 大连医科大学学报, 2013,35(6): 611-613.
[28] BROERS C, TACK J, PAUWELS A. Review article: gastro-oesophageal reflux disease in asthma and chronic obstructive pulmonary disease[J]. Aliment Pharmacol Ther, 2018,47(2): 176-191.
[29] CHRISTIE J D, EDWARDS L B, KUCHERYAVAYA A Y, et al. The registry of the international society for heart and lung transplantation: 29th adult lung and heart-lung transplant report-2012[J]. J Heart Lung Transplant, 2012,31(10): 1073-1086.
[30] HATHORN K E, CHAN W W, LO W K. Role of gastroesophageal reflux disease in lung transplantation[J]. World J Transplant, 2017,7(2): 103-116.
[31] 陈军, 方泽民, 魏翔, 等. 肺移植术后胃食管反流病预防和治疗的初步经验[J]. 临床外科杂志, 2015,23(10): 776-778.
[32] SUEN H C, HENDRIX H, PATTERSON G A. Physiologic consequences of pneumonectomy. consequences on the esophageal function[J]. Chest Surg Clin N Am, 1999,9(2): 475-483, xiii.
[33] HADJILIADIS D, DUANE D R, STEELE M P, et al. Gastroesophageal reflux disease in lung transplant recipients[J]. Clin Transplant, 2003,17(4): 363-368.
[34] FISICHELLA P M, REDER N P, GAGERMEIER J, et al. Usefulness of pH monitoring in predicting the survival status of patients with scleroderma awaiting lung transplantation[J]. J Surg Res, 2014,189(2): 232-237.

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 13

Recommended Articles

Metrics

Comments

[1]	. [J]. Journal of Hebei Medical College for Continuing Education, 2023, 40(3): 28-37.
[2]	. [J]. Journal of Hebei Medical College for Continuing Education, 2023, 40(2): 18-24.
[3]	ZHANG Jinghui,ZHAO Hanqing,WANG Zewen,XIANG Hongwei,GE Shaoqin. Simple obesity and application of TCM Piwei theory [J]. Journal of Hebei Medical College for Continuing Education, 2022, 39(3): 54-59.
[4]	WANG Jing, HAN Li, ZHANG Zeming. Advances on chronic obstructive pulmonary disease associated pulmonary hypertension [J]. Journal of Hebei Medical College for Continuing Education, 2022, 39(3): 21-28.
[5]	. [J]. Journal of Hebei Medical College for Continuing Education, 2021, 38(6): 36-43.
[6]	. [J]. Journal of Hebei Medical College for Continuing Education, 2021, 38(2): 21-25.
[7]	. [J]. Medical Reserch and Education, 2018, 35(6): 30-33.
[8]	. [J]. Medical Reserch and Education, 2018, 35(6): 1-4.
[9]	. [J]. Medical Reserch and Education, 2018, 35(4): 11-18.
[10]	. [J]. Medical Reserch and Education, 2018, 35(2): 13-16.
[11]	ZHENG Pei, GAO Wei, CHEN Ying. The pathogenesis, prevention and nursing of critically ill patients complicated with stress ulcer [J]. Medical Reserch and Education, 2015, 32(1): 80-84.
[12]	ZHANG Ke,LIU Junfeng,XIANG Shasha,KANG Meng,DAI Yue. Mechanism of gastroesophageal relfux disease pathogenesis and its symptom perception [J]. Medical Reserch and Education, 2014, 31(4): 71-74.
[13]	ZHANG Qingyun,DONG Xiaodong,HAO Yuan,CHEN Yumin. Study on the pathogenesis of Parkinson’s disease [J]. Medical Reserch and Education, 2013, 30(3): 85-88,99.