Journal of Hebei Medical College for Continuing Education

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Advances on the role of purine receptor in blood pressure regulation

WANG Xinxin, LI Lu, WU Guangyi

Journal of Hebei Medical College for Continuing Education 2022, 39 (1): 1-7. DOI: 10.3969/j.issn.1674-490X.2022.01.001

Abstract （330）

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Hypertension is a multi-factor disease with unknown etiology and serious complications. Due to the complexity of this disease, the pathogenesis of most patients with essential hypertension is still unknown. A large body of evidence shows that the purinoceptor signaling pathway plays a key role in a variety of diseases and constitutes a ubiquitous intercellular communication system. Almost all purinoceptors are expressed on the cells of the cardiovascular system. Some purine receptor subtypes has been confirmed in blood pressure regulation according to the existing research results and conjectures, but the knowledge is still limited. With the increasing understanding of the pathophysiology of purinoceptors, purine receptor compounds are also being developed for the treatment of hypertension. Therefore, the article summarizes the effects of purinoceptors on blood pressure and the latest research developments.

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Identification and bioinformatics analysis of key neutrophil genes in patients with primary antiphospholipid syndrome

LIN Meiying, GAN Donghui, GAO Ying, WANG Zhengjie,CHEN Zhimin

Journal of Hebei Medical College for Continuing Education 2022, 39 (1): 8-14. DOI: 10.3969/j.issn.1674-490X.2022.01.002

Abstract （282）

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Objective To screen key differential genes and identify the biological functions and signaling pathways involved in neutrophils from patients with primary antiphospholipid syndrome(APS)by bioinformatic methods. Methods RNA sequencing data of neutrophils from APS patients were downloaded from the GEO database, differentially expressed genes were screened by using the limma package in R language, and up- and down-regulated genes were subjected to gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis by clusterProfiler, respectively. Finally, protein-protein interaction network was constructed by STRING database and core genes in the network were calculated using cytoscape software. Results A total of 512 up-regulated genes and 473 down-regulated genes were obtained by limma package screening. Up-regulated genes were mainly involved in functions and pathways including regulation of innate immune response, neutrophil activation, inflammatory complex formation, etc. down-regulated genes were mainly involvedin functions and pathways including T cell activation, lymphocyte differentiation, lymphocyte activation, etc. IFIT1, IFI35, IFI3, CCL2, TLR8, FCGR1A were the core genes among the up-regulated genes. MYC, CD8A, FYN,CD28, LCK, GNB2L1 were the core genes among the down-regulated genes. Conclusion The core genes identified by bioinformatic methods may be the key targets for the immune effects of neutrophils in patients with primary antiphospholipid syndrome.

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Developments on risk factors of complications in joint replacement

HE Zhenqiang,ZHU Lin,PANG Jingwen,YIN Xiujuan,JIAO Jianbao

Journal of Hebei Medical College for Continuing Education 2022, 39 (1): 15-24. DOI: 10.3969/j.issn.1674-490X.2022.01.003

Abstract （318）

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With the acceleration of China's aging process, the incidence of chronic bone and joint diseases is increasing year by year, and one of the most effective treatments is total joint arthroplasty. At present, total joint arthroplasty has been widely used in clinic, but some patients still have complications. Because the preoperative factors of total joint arthroplasty can affect the incidence of postoperative complications, by improving the preoperative risk factors, we can provide the patients with artificial joint replacement with the best operation opportunity and reduce the incidence of surgical complications. This paper introduces the influence of common preoperative risk factors of total joint arthroplasty on the incidence of postoperative complications, hoping to provide some guidance for orthopedic surgeons in preventing postoperative complications.

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Developments on radiogenomics based on MRI in lung cancer brain metastases

SUI Lianyu, YIN Xiaoping, WANG Jianing

Journal of Hebei Medical College for Continuing Education 2022, 39 (1): 25-34. DOI: 10.3969/j.issn.1674-490X.2022.01.004

Abstract （387）

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Brain metastases are intracranial malignant tumors with high incidence and poor prognosis, brain metastases from lung cancer are the most common in clinical practice. MR is the preferred imaging diagnosis method for intracranial tumors, and MRI imagingomics is gradually applied to the precise and individualized diagnosis and treatment of brain metastases. With the continuous in-depth research on the connection between genes and tumors, tumor diagnosis is extended to the direction of molecular genetics. Radiogenomics is a method of fusing imaging phenotypes with genes and molecules, using non-invasive and accurate methods to detect tumors. The molecular genetic changes of the disease have been widely used in tumor discovery, treatment guidance and prognosis prediction, etc. This article reviews the feasibility and research progress of MRI radiogenomics radio genomics in brain metastases.

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Value of bedside technology in diagnosis and monitoring of acute pulmonary edema

LI Luxi, CHEN Fang, WANG Bin, ZHAN Xiuwen, LIANG Lu

Journal of Hebei Medical College for Continuing Education 2022, 39 (1): 35-40. DOI: 10.3969/j.issn.1674-490X.2022.01.005

Abstract （306）

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Acute pulmonary edema disease is a common clinical emergency and critical illness, and the disease develops rapidly, and it is necessary to have timely and effective diagnosis and treatment, otherwise it is easy to endanger the life of patients. Therefore, it is necessary to make early and correct diagnosis of acute pulmonary edema, especially to clarify its etiology, which is very important for the treatment and prognosis of patients. This article reviews the diagnostic and monitoring value of bedside technique in acute pulmonary edema.

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Advances on recurrence of secondary hyperparathyroidism after parathyroidectomy

JIN Qiu, LIANG Yulong

Journal of Hebei Medical College for Continuing Education 2022, 39 (1): 41-48. DOI: 10.3969/j.issn.1674-490X.2022.01.006

Abstract （358）

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Disturbance of calcium and phosphorus metabolism in chronic renal failure patients with long-term dialysis can cause compensatory hyperplasia of parathyroid gland and the increase of intact parathyroid hormone(iPTH)known as renal hyperparathyroidism(HPT)or secondary hyperparathyroidism(SHPT),clinical manifestations can include high parathyroidin, high calcium or hypocalcemia, and persistent high phosphorus. It can lead to diseases of skeletal system, neuropsychiatric system, blood system and cardio-cerebrovascular system, seriously affecting the quality of life and life span. The 2017 Global Guidelines for Kidney Disease recommend Chronic Kidney Disease(CKD)stage 3-5 complicated with severe hyperparathyroidism that does not respond to drug therapy, and parathyroidectomy is recommended. The problem of postoperative recurrence rate affects the further promotion of surgery. Although ultrasound and radionuclide scanning techniques have become more sophisticated in the past few years, it is still not possible to ensure complete preoperative localization of all parathyroids, especially those with less hyperplasia. The recurrence rate of subtotal resection and total resection plus autologous transplantation is higher than that of total resection, so total resection is more recommended for the prevention of recurrence. In addition, the improvement of preoperative localization, thymotomy, intraoperative parathyroid hormone monitoring and intraoperative nerve monitoring also contributed to the reduction of postoperative recurrence.

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Challenges and countermeasures of population aging to public health service

CHENG Huaizhi, GUO Bin, SONG Jiawei, LI Yu

Journal of Hebei Medical College for Continuing Education 2022, 39 (1): 49-53. DOI: 10.3969/j.issn.1674-490X.2022.01.007

Abstract （1386）

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China is facing a huge medical challenge from its aging problem. By 2050, China's population aged 65 and above will reach 400 million, of which the population aged 80 and above will reach 150 million. This paper reviews the evolution and current situation of population aging systematically through literature review, and analyzes some public health problems caused by China's aging population from the perspective of economic: underutilization of health service, the rapid rise of health costs, the huge demand for nursing service. It is suggested that we should strengthen health education for the elderly, expand nursing service, provide individual nursing care for them, further improve the medical security system and build a sustainable long-term care insurance system.

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Current situation and development strategy of community hospice care in China

JIN Yan, QIAO Yanhua

Journal of Hebei Medical College for Continuing Education 2022, 39 (1): 54-60. DOI: 10.3969/j.issn.1674-490X.2022.01.008

Abstract （841）

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By combing the development model and experience of community hospice care in China, this paper analyzes the main problems existing in the development of community hospice care, and puts forward reasonable suggestions for the development of community hospice care in China, such as increasing support and guarantee, strengthening the construction of talent team, establishing a correct concept of life and death so as to promote the faster and better development of domestic community hospice care services.

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Discussion on improving community home-based elderly care model based on appreciative inquiry

SHANG Dongxu, LU Xiangyu, WANG Xinxin, WANG Lina, GUO Yufang

Journal of Hebei Medical College for Continuing Education 2022, 39 (1): 61-67. DOI: 10.3969/j.issn.1674-490X.2022.01.009

Abstract （319）

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The community home-based elderly care model is one of the elderly care models vigorously implemented in China. However, due to the particularity of the elderly group, there are some problems in the implementation of the community home-based elderly care model, such as the shortage of medical resources, the low degree of specialization and cooperation of service personnel, the poor interaction of multiple information, and the incomplete expression of the needs of the elderly. As a new way of organizational change, appreciative inquiry provides new ideas to solve the above problems. From the perspective of realizing the goal of appreciative inquiry, this paper puts forward relevant suggestions to improve the community home-based elderly care model in order to provide reference for improving the community home-based elderly care model.

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Current status of research on clinical progress management of benign prostatic hyperplasia

JIANG Dongxu, ZOU Hao, SUN Min, ZHANG Linlin

Journal of Hebei Medical College for Continuing Education 2022, 39 (1): 68-74. DOI: 10.3969/j.issn.1674-490X.2022.01.010

Abstract （410）

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In recent years,with the acceleration of aging,the prevalence of benign prostatic hyperplasia(BPH)has shown an increasing trend,seriously affecting the quality of life of elderly men,and at the same time,it has brought an economic burden to the global medical care service system. In order to explore the current status of BPH management methods at home and abroad,an integrated analysis was carried out by searching relevant literature on BPH clinical progress management. At present,in order to delay and change the clinical progress of BPH patients,management methods combining clinical and non-clinical interventions have been adopted at home and abroad,and some results have been achieved,but there are still certain limitations. This paper analyzes and summarizes the current research status, and provides a reliable basis for the management of BPH clinical progress in the later stage.

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Advances on cancer-related fatigue and its influencing factors in patients with cervical cancer

GUO Xinran, JING Kunjuan, ZHANG Lingling, WANG Bei

Journal of Hebei Medical College for Continuing Education 2022, 39 (1): 75-80. DOI: 10.3969/j.issn.1674-490X.2022.01.011

Abstract （345）

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This paper summarizes the current situation of cancer-related fatigue in patients with cervical cancer, and analyzes the impact of different factors on cancer-related fatigue, which is helpful to help nurses implement targeted and scientific nursing intervention, effectively alleviate cancer-related fatigue and improve the quality of life of patients.

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The key role of Nrf2 in ischemic stroke

ZHU Jianping, LI Yunman

Journal of Hebei Medical College for Continuing Education 2022, 39 (2): 1-9. DOI: 10.3969/j.issn.1674-490X.2022.02.001

Abstract （502）

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Ischemic stroke is one of the main causes of death and disability worldwide. Nuclear factor E2-related factor 2(Nrf2)is an important transcription factor that regulates the balance of the body's redox reaction. It participates in resisting endogenous or exogenous stress by coordinating a variety of cytoprotective genes. The Nrf2 signaling pathway not only strictly regulates the body's redox homeostasis, but also participates in the regulation of multiple processes in the body metabolism. Therefore, targeting Nrf2 has become a potential strategy for the prevention and treatment of central nervous system diseases including ischemic stroke. In this review, we first introduced the structural features of Nrf2 and Kelch-like ECH-related protein 1(Keap1), and briefly described the activation and regulation of the Nrf2 pathway. Next, we discussed the pathological and physiological mechanism, upstream regulators and downstream targets of the Nrf2 pathway. In this context, we extended the discussion to the role of Nrf2 after ischemic stroke and explored potential therapeutic directions.

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Effects of PDCD5 on the patients with severe influenza

LI Ming, SU Wei, MA Shiheng, WANG Tao

Journal of Hebei Medical College for Continuing Education 2022, 39 (2): 10-15. DOI: 10.3969/j.issn.1674-490X.2022.02.002

Abstract （201）

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Objective To analyze the clinical complications of patients with influenza pneumonia in different PDCD5 levels and the risk factors of severe influenza patients. Methods 104 patients with influenza treated in our hospital from June 2020 to December 2020 were divided into HP group(PDCD5>10 μg/L, n=38)and LP group(PDCD5≤10 μg/L, n=66). They were divided into mild disease group(n=61)and severe disease group(n=43)according to the severity. The incidence of respiratory failure, cardiac myositis and multiple organ failure(MODS)were analyzed. The general and clinical data of the two groups were compared, and the independent risk factors of severe patients were analyzed with multivariate logistic regression. Results The incidence of respiratory failure, myocarditis and MODS in HP group were higher than those in LP group(P<0.05). Univariate analysis showed that there were significant differences between severe group and mild group in BMI, smoking history, COPD, MMP9, PaO₂/FiO₂, lymphocyte, lymphocyte subsets and PDCD5 level(P<0.05). Multivariate logistic regression analysis showed that low lymphocyte and CD4⁺T cell, high PCT and PDCD5>10 μg/L were independent risk factors for patients with severe influenza(P<0.05). Conclusion Lymphocytes, CD4⁺T lymphocytes, PDCD5 and PCT may affect the disease progression and more attention should be paid to those indexes.

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Advances on vasculogenic mimicry in breast cancer

WEI Yali,SUN Chengcheng,WANG Xiaochun

Journal of Hebei Medical College for Continuing Education 2022, 39 (2): 16-23. DOI: 10.3969/j.issn.1674-490X.2022.02.003

Abstract （372）

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Vasculogenic mimicry is a special model of angiogenesis. This structure is composed of tumor cells instead of traditional endothelial cells, and provides nutrition for tumor growth, invasion and metastasis. In recent years, it has been found that vasculogenic mimicry is related to the prognosis, invasion, metastasis and drug resistance of many kinds of malignant tumors. It is generally believed that vasculogenic mimicry and angiogenesis depend on some common mechanisms. And some people believe that the formation of vasculogenic mimicry is one of the reasons leading to the development of resistance to anti-angiogenic drugs. The mechanism of vasculogenic mimicry in breast cancer, including related signaling pathways, as well as tumor stem cells, epithelial mesenchymal and anti angiogenesis therapy, are reviewed. The significance and future direction of vasculogenic mimicry as a therapeutic target for breast cancer will be prospected.

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Diurnal distribution characteristics and related influencing factors of febrile seizures in children

HOU Ting,ZHONG Xiaoyi,WEI Jihong

Journal of Hebei Medical College for Continuing Education 2022, 39 (2): 24-28. DOI: 10.3969/j.issn.1674-490X.2022.02.004

Abstract （249）

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Objective To explore the diurnal distribution characteristics and related factors of the number of febrile convulsions in children. Methods The diurnal distribution characteristics of 443 children with febrile convulsion hospitalized in the Department of Pediatrics of Affiliated Hospital of Hebei University from January 2014 to December 2019 were analyzed retrospectively. The effects of gender(male/female), age at onset(≤3 years old/>3 years old), gestational age(preterm birth/term birth)and birth mode(caesarean delivery/natural delivery)on the day-night distribution of febrile seizures were analyzed. Results The diurnal distribution of the number of seizures was different(χ²=5.411,P=0.020), the results of univariate analysis showed that there were differences in the day and night distribution of seizures in children with different genders, age at first onset, and gestational age(all P<0.05). Logistic regression analysis showed that age at onset and gestational age the influencing factors of the diurnal distribution of febrile seizures in children, and the differences were statistically significant(all P<0.05).Conclusion The diurnal distribution of the number of febrile convulsions in children has certain characteristics, which is affected by age at onset and gestational age.

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A bibliometric analysis of 10 years in the hot research and development trend of Yishui school based on CiteSpace

XU Heng, ZHANG Jinmin, ZHANG Yaqi, LIU Dasheng, LI Fuhai, GE Shaoqin, ZHAO Hanqing

Journal of Hebei Medical College for Continuing Education 2022, 39 (2): 29-40. DOI: 10.3969/j.issn.1674-490X.2022.02.005

Abstract （399）

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In order to analyze and discuss the research hotspots and development trends of the Yishui school in the field of domestic scholars in the past 10 years, the relevant literature of the Yishui school in CNKI, Wanfang, VIP in the recent 10 years were explored using bibliometrics. The CiteSpace software was applied to draw a knowledge map, and the amount of articles, research teams, issuing organizations, and keywords were visually analyzed and retrieved. The study included 2 397 related documents, 3 649 keywords, 17 keyword clusters; 53 authors published more than 5 articles, and found that Zhang Baochun and Ren Beida, Liu Guirong and Yao Wenxuan, Li Fuping and Dong Shangpu and other scholars were the three major academically influential teams represented mainly focus on Li Dongyuan and Piwei theory. In the past five years, they had begun to pay attention to other Yishui school representatives during the Ming and Qing Dynasties. In the past two years, we had produced certain results in the context of new coronavirus pneumonia, but the overall analysis of the internal organs identification theory and other researches were slightly insufficient, and the research methods were slightly outdated, suggesting that in the future we should strengthen the research on the traceability of the Yishui school and further improve the inheritance system of the Yishui school.

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Influencing factors of deciduous teeth caries of preschool children in China:a Meta analysis

WANG Mi, CHEN Jingjing, LIU Fang, ZHANG Yan, QI Jing

Journal of Hebei Medical College for Continuing Education 2022, 39 (2): 41-47. DOI: 10.3969/j.issn.1674-490X.2022.02.006

Abstract （354）

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Objective To provide reference for the prevention of deciduous caries of preschool in China by analyzing the influencing factors of deciduous caries of preschool. Methods Computer retrieval of clinical case-control trial literatures meeting the requirements was conducted on common databases including Embase, Cochrane Library, Pubmed, Web of Science, Chinese Academic Journal Full-Text Database(CNKI), Wanfang Database, Viper and Chinese Biomedical Literature Database(CBM)at home and abroad, and the retrieval time was from build libraries to October 2020. Chinese and English literatures related to the factors affecting primary tooth caries in preschool children were collected, and the quality of the included literatures was strictly evaluated by 2 researchers, and the data of middle and high quality literatures were extracted. Results A total of 5 730 subjects were included in 10 articles, including 3 012 cases with caries and 2 718 cases without caries. The Meta analysis results showed that the risk factors of caries in preschool in China were: brushing times <1(OR=3.06,95%CI=2.08-4.48,P<0.05), frequently eating sweets or candies(OR=1.33,95%CI=1.17-1.51,P<0.05), eating sweets before going to bed(OR=2.94,95%CI=1.64-5.26,P<0.05). Gargle habit(OR=0.36, 95%CI=0.23-0.57, P<0.05)is an important protective factor of caries in preschool children in China. Conclusion The establishment of good oral hygiene habits is helpful to reduce the risk of dental caries in preschool children in China。

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Application progress of Snyder's hope theory in the nursing of chronic non-malignant patients

PANG Lin, JING Kunjuan

Journal of Hebei Medical College for Continuing Education 2022, 39 (2): 48-53. DOI: 10.3969/j.issn.1674-490X.2022.02.007

Abstract （353）

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Chronic non-malignant diseases refer to other chronic diseases other than cancer, which cause serious psychological burden to patients and their families due to the persistence of the disease. Hope, as an inner psychological force, can enhance the patient's self-confidence in the face of the disease. This paper introduces the connotation of Snyder's theory of hope, summarizes and analyzes the influencing factors of the hope level of chronic non-malignant patients and the application status of hope theory in the nursing of chronic non-malignant patients, and provides a reference for the development of targeted intervention measures for chronic non-malignant patients.

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A meta-analysis of the detection rate of dysphagia in patients with acute stroke

YANG Yang, WANG Jue, LIU Ning

Journal of Hebei Medical College for Continuing Education 2022, 39 (2): 54-65. DOI: 10.3969/j.issn.1674-490X.2022.02.008

Abstract （270）

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Objective To systematically evaluate the status of dysphagia in patients with acute stroke. Methods PubMed, EMbase, Web of Science, The Cochrane Library, Chinese Biomedical Literature Database(CBM), VIP, CNKI, WanFang and other databases were used to search literatures on the detection rate of dysphagia in patients with acute stroke from the establishment of the database to November 5, 2021. Two nursing researchers independently screened the retrieved literatures according to the inclusion and exclusion criteria, extracted data, and evaluated the bias risk of the included literatures. Then Stata16 software was used for Meta analysis. Results A total of 29 articles were included, including 26799 subjects. The prevalence of dysphagia in acute stroke patients was 53%(95%CI:0.46-0.60). Subgroup analysis showed 20% of males(95%CI:0.17-0.22)and 20% of females(95%CI:0.17-0.24). The detection rates were 6%(95%CI:-0.03-0.15)in patients under 50 years old, 9%(95%CI:0.04-0.15)in patients 50 to 59 years old, 26%(95%CI:-0.04-0.56)in patients 60 to 69 years old, 29%(95%CI:0.03-0.54)in patients aged 70-79 years, and 39%(95%CI:-0.24-1.03)in patients aged 80 years or older. The prevalence of dysphagia in cerebral stem, cerebellum, cerebellum, brainstem + cerebellum and brainstem + hemisphere stroke patients was 39%, 13%, 21%, 33% and 90% respectively. The detection rates of swallowing disorders in patients with total anterior circulation infarction(TACI), partial anterior circulation infarction(PACI), posterior circulation infarction(POCI)and lacunar infarction(LACI)were 58%, 25%, 26% and 16% respectively. The prevalence of dysphagia in patients with cardiogenic stroke, large vessel occlusion, small vessel occlusion and atherosclerosis was 18%, 14%, 9% and 14% respectively. The prevalence of dysphagia in patients with hypercholesterolemia, hypertension, smoking, diabetes, atrial fibrillation and hyperlipidemia were 19%, 22%, 19%, 22%, 22% and 10% respectively. The prevalence of dysphagia in hypertension, diabetes, smoking and drinking was 28%, 27%, 38% and 16% respectively. Conclusion The rate of dysphagia in acute stroke patients is high. However, due to the limitations of the quality and quantity of the included literatures, the above conclusions still need to be verified by incorporating higher-quality literatures.

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Advances on drug management in patients with inflammatory bowel disease

LUO Fameng, LIU Rong, ZHANG Haiyan

Journal of Hebei Medical College for Continuing Education 2022, 39 (2): 66-71. DOI: 10.3969/j.issn.1674-490X.2022.02.009

Abstract （231）

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In recent years, the incidence of inflammatory bowel diseases(IBD)has been increasing in China, and it is a common digestive system disease mainly manifested as long-term and persistent repeated inflammation. This paper induced, summarized and analyzed relevant literatures on drug management of IBD patients at home and abroad in recent years, and expounded whether it could improve patients' drug management ability, improve their cognition of disease and improve their quality of life, so as to provide reference for hospitals or communities to implement drug management of IBD.

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Construction of clinical competence evaluation index system for oral cavity undergraduate interns

Ma binger, Chen Huishan, Wang Haiyou, Lu Yanhui, Zhou Yuan, Yang Huixiao

Journal of Hebei Medical College for Continuing Education 2022, 39 (2): 72-80. DOI: 10.3969/j.issn.1674-490X.2022.02.010

Abstract （271）

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Objective To construct a clinical ability evaluation index system for oral cavity undergraduate interns to apply to the evaluation of clinical competence of oral cavity undergraduate interns, and to promote the whole oral clinical practice teaching, and to improve the comprehensive clinical quality of interns. Methods Based on the literature review, this study preliminarily constructed the clinical competence evaluation index system for oral cavity undergraduate interns, and used Delphi expert consultation to conduct two rounds of expert consultation, and selected the clinical competence evaluation index system for oral cavity undergraduate interns and and determined the weight by using analytic hierarchy process and percentage weight method.Results After two rounds of Delphi's expert consultation,an index system of clinical ability evaluation for oral cavity undergraduate interns with 8 primary indicators and 55 secondary indicators was constructed and its weight was determined.Conclusion Based on the reasonable application of Delphi's expert consultation method, this study established a clinical competence evaluation index system for oral undergraduate interns, which is comprehensive and suitable for the evaluation of clinical competence of oral cavity undergraduates. The index system is conducive to discovering the problems existing in the interns during the internship and promptly recommending improvement strategies, and playing a guiding role in improving the clinical ability of the interns.

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The effect of interferon-α2b on PD-1/PD-L1 signaling pathway of HEL cells

QI Lin,CHENG Zhiyong,ZHANG Lijun,WANG Meng,WANG Baoyan

Journal of Hebei Medical College for Continuing Education 2022, 39 (3): 1-8. DOI: 10.3969/j.issn.1674-490X.2022.03.001

Abstract （253）

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Objective To study the effects of interferon-α2b(IFN-α2b)on proliferation and apoptosis and the influence with programmed death-1(PD-1)and programmed death ligand-1(PD-L1)of JAK2 V617F positive human erythroleukemia HEL cells. Methods Different concentrations of IFN-α2b were applied to human erythroleukemia HEL cell lines. CCK-8 was used to detect cell viability and caspase-3/7 activity was detected by caspase-3/7 activity assay kit. The expression levels of JAK2, PD-1 and PD-L1 mRNA were detected by fluorescence quantitative PCR. Flow cytometry was used to detect the effects of different concentrations of interferon-α2b on the expression of PD-1 and PD-L1 protein in HEL. Results Different concentrations of IFN-α2b could inhibit HEL cell proliferation in time and dose-dependent manner. IFN-α2b could increase caspase-3/7 activity of HEL cells in a dose and time-dependent manner; IFN-α2b could reduce JAK2 V617F mutation in a dose-dependent manner,inhibit the expression of PD-1 mRNA and protein, and slightly increase the expression of PD-L1.Conclusion IFN -α2b may inhibit HEL proliferation and participate in the regulation of PD-1/PD-L1 expression.

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Advances on determination methods of flavonoids in Chinese herbal medicine

YANG Hui,YANG Tianrun,MA Ziyun

Journal of Hebei Medical College for Continuing Education 2022, 39 (3): 9-13. DOI: 10.3969/j.issn.1674-490X.2022.03.002

Abstract （1017）

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Flavonoids are a kind of natural organic compounds widely existing in plants and are abundant in many Chinese herbal medicines. As an effective component of many traditional Chinese medicines, flavonoids play an important role in the treatment of diseases due to their extensive physiological or pharmacological activities, and are widely used in clinical practice. Therefore, the determination of such compounds in Chinese herbal medicine is one of the important links in drug quality control. In this paper, different determination methods of flavonoids in Chinese herbal medicine are reviewed.

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Role of binocular vision function in the progression of myopia

GAO Chunting, YUAN Hui, DU Junhui

Journal of Hebei Medical College for Continuing Education 2022, 39 (3): 14-20. DOI: 10.3969/j.issn.1674-490X.2022.03.003

Abstract （554）

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Myopia is a common disease in the population, and its incidence is increasing year by year, especially in children and adolescents, seriously affecting their physical and mental health. Binocular vision refers to that two eyes see at the same time, while external objects fall on the retina, forming retinal images, nerve excitatory transmission go to the brain higher center, so that the visual signals of two eyes merge into a single perceptual object. When viewing stereoscopic objects, due to the difference of normal pupil distance and the angle of faxation, the images formed on the retina of the two eyes are not completely symmetrical and have certain horizontal difference. This phenomenon is called Binocular Parallax, which gives us stereoscopic perception. Many studies have shown that binocular vision functions such as accommodation, convergence, stereoscopic vision and the development of myopia interact.The purpose of this article is to review the developments of binocular vision function and myopia in order to provide reference for the prevention and control of myopia to choose effective and appropriate programs.

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Advances on chronic obstructive pulmonary disease associated pulmonary hypertension

WANG Jing, HAN Li, ZHANG Zeming

Journal of Hebei Medical College for Continuing Education 2022, 39 (3): 21-28. DOI: 10.3969/j.issn.1674-490X.2022.03.004

Abstract （332）

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Chronic obstructive pulmonary disease(COPD)has become a global public health problem due to its large number of patients, high mortality rate and heavy social and economic burden. Pulmonary hypertension, pulmonary heart disease and heart failure caused by COPD seriously threaten life health and quality of life of patients. The quality of life can be improved if the disease can be controlled in time, effectively controlled and slowed down. This article reviews the pathogenesis, clinical manifestations, diagnosis and treatment of COPD associated pulmonary hypertension.

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Advances on radiomics in adrenal adenoma

WU Chunmei, YIN Xiaoping

Journal of Hebei Medical College for Continuing Education 2022, 39 (3): 29-34. DOI: 10.3969/j.issn.1674-490X.2022.03.005

Abstract （376）

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Adrenal adenoma is a common tumor in clinical practices. At present, initial progress has been made in the identification of adrenal benign and malignant tumors, functional adrenal adenoma subtypes, lipid adenoma and pheochromocytoma. Studies on adrenal adenoma are mainly carried out through texture analysis and histogram analysis, which can effectively evaluate tumor atypia and provide effective help in clinical decision-making.In addition, the normogram model combining clinical features and imaging features has a good identification effect for functional adrenal adenoma subtypes. The purpose of this article is to review the current status, problems and prospects of imaging in the diagnosis and differential diagnosis of adrenal adenoma, and the prediction, monitoring and prognosis of treatment strategies.

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Prospect of treatment of retinal vein edema combined with macular edema

HAO Jianzhang, ZHANG Hu

Journal of Hebei Medical College for Continuing Education 2022, 39 (3): 35-40. DOI: 10.3969/j.issn.1674-490X.2022.03.006

Abstract （366）

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Retinal vein occlusion(RVO)is the most common retinal vascular disease and one of the most common causes of blindness. The incidence of RVO increases with age. Most patients are over 65 years old, but the age of onset of the disease is also getting younger because of changes in the Chinese diet. Macular edema, often accompanied by retinal vein occlusion, is also a major cause of vision loss in patients with the disease.At present, there are many treating approaches for the patients with retinal vein occlusion combined with macular edema. Each method has its different effects due to the individual differences of the patients. To date, different treatment schemes are conducted according to the patients' own conditions, and most of them are combined with several treatment methods. By consulting relevant literatures and personal experience in the process of treating patients, the author summarizes and discusses the prospects of the treatment methods, curative effects, prognosis and costs of retinal vein occlusion complicated with macular edema, so as to find potential problems and influencing factors and explore the best clinical treatment regimen.

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Application of ultrasound monitoring of inferior vena cava diameter in critically ill patients

HUANG Jiahui, FU Tingfei, LIANG Lu

Journal of Hebei Medical College for Continuing Education 2022, 39 (3): 41-46. DOI: 10.3969/j.issn.1674-490X.2022.03.007

Abstract （293）

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Ultrasound monitoring of the inferior vena cava is a non-invasive, safe and repeatable technique, which can avoid adverse reactions such as infection due to invasive operations. Its diameter is correlated with central venous pressure, can reflect the patient's capacity status, assess the patient's condition development timely and accurately, and grasp the best treatment opportunity, which has guiding significance for the treatment of critically ill patients.

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Developments on Kümmell's disease

ZHANG Yin'en, JIAO Jianbao

Journal of Hebei Medical College for Continuing Education 2022, 39 (3): 47-53. DOI: 10.3969/j.issn.1674-490X.2022.03.008

Abstract （380）

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Kümmell's disease(KD)is a delayed form of vertebral ischemic necrosis after minor trauma. KD shows delayed vertebral compression fracture, and the most common lesion is at the junction of thoracolumbar spine. Patients with KD often have a history of minor trauma. Although the postoperative pain disappears, the symptoms often relapse and worsen, and kyphosis deformity occurs many years later.The diagnosis of KD depends not only on imaging technology, but also on the comprehensive analysis of patients' medical history and clinical symptoms. Intraspinal fracture caused by trauma is considered to be the most important feature in the diagnosis of KD. Patients with KD can adopt different treatment schemes according to whether there is nerve defect. Patients with KD without nerve defect can be treated with conservative treatment, percutaneous vertebroplasty(PVP), percutaneous kyphoplasty(PKP)and other methods.However, the above methods are often accompanied by leakage of bone cement.With the development of modern medicine and technology, in order to reduce the leakage of bone cement, clinicians have made a series of improvements to the operation on the basis of PVP, PKP, anterior reconstruction and posterior osteotomy, which effectively reduces the occurrence of complications and improves the quality of life of patients.

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Simple obesity and application of TCM Piwei theory

ZHANG Jinghui,ZHAO Hanqing,WANG Zewen,XIANG Hongwei,GE Shaoqin

Journal of Hebei Medical College for Continuing Education 2022, 39 (3): 54-59. DOI: 10.3969/j.issn.1674-490X.2022.03.009

Abstract （319）

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Simple obesity refers to obesity without obvious disease inducement, which is caused by genetic factors and environmental factors.Clinical practice shows that the TCM treatment of simple obesity has the advantages of small side effects, significant curative effect and high degree of patient acceptance.The theory of Piwei plays an important role in the treatment of simple obesity as an important practical theoretical basis in the clinical application of TCM.This paper analyzes the etiology and pathogenesis of simple obesity by combining the clinical experience of the treatment of simple obesity in recent years, and systematically discusses the application of Piwei theory in the clinical treatment of simple obesity, so as to provide some reference for the guidance of clinical practice.

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Mediating effect of nurses' practicing environment on safety attitude and occupational well-being

WANG Bei,MENG Jia,DU Xiaojing,WANG Weiming,QI Xinrong

Journal of Hebei Medical College for Continuing Education 2022, 39 (3): 60-66. DOI: 10.3969/j.issn.1674-490X.2022.03.010

Abstract （328）

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Objective To explore the mediating effect of nurse practice environment on safety attitude and occupational well-being and give analysis of the role of working environment on safety attitude-occupational well-being. Methods From October to December,2021,cluster sampling was used to select 1 939 nurses from 5 tertiary hospitals in Baoding City as study subjects. The Nursing Work Index-Revised,the revised Chinese version of Safety Attitude Questionnaire(SAQ),and medical workers' occupational well-being scale were used to collect the data through “Question Star” on nurses' practicing environment and safety attitude and occupational well-being and analyze their correlation and mediating effect. Results 1939 nurses had a mean practicing environment score of 68.81±27.79,the mean SAQ score was 111.28±14.38, and the mean occupational well-being score of 62.43±28.17. Nurses' practicing environment and safety attitude,occupational well-being and safety attitude,occupational well-being and nurses' practicing environment were all significantly positively correlated(r=0.626,0.690,0.699,all P <0.05).Both of nurses' practicing environment and safety attitude could significantly predict occupational well-being. The mediating effect of nurses' practicing environment between occupational well-being and safety attitude was 0.268,which accounted for 42.405 percent of the total effect. Conclusion The nurses' practicing environment,safety attitude and occupational well-being of the third-grade hospitals in Baoding are not satisfactory. As part of the intermediary variables,the practice environment indirectly influences the relationship between safety attitudes and occupational well-being. Therefore, it is necessary to improve the nurse's working environment, strengthen the safety attitude, and promote the nurses' occupational happiness.

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Reproductive concern status and its influencing factors in gynecological cancer patients

XU Li,LIU Wenjuan,ZHANG Li

Journal of Hebei Medical College for Continuing Education 2022, 39 (3): 67-73. DOI: 10.3969/j.issn.1674-490X.2022.03.011

Abstract （263）

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Objective To understand the level of reproductive concern in gynecological cancer patients, and explore its status and influencing factors. Methods Reproductive Concerns after Cancer Scale(RCACs)and Self-perceived Burden Scale for Cancer Patients(SPBS-CP)were collected from 134 gynecologic cancer patients. Results Average RCAC score in gynecological cancer patients was 48.88±13.59.SPBS-CP score was 50.92±17.38.There were differences in reproductive concern levels among patients in different groups(age, willingness to bear children, number of children, content of communication, and self-perceived burden level)(P<0.01).Self-perceived burden and all dimensions were positively correlated with reproductive concern(P< 0.01). After multiple linear regression analysis:Fertility willingness and self-perceived burden were important independent influencing factors of reproductive concern in gynecological cancer patients(P< 0.01).Conclusion Gynecological cancer patients reproductive concern is above medium level. Attention should be paid to those with reproductive needs and heavy self-perceived burden. Taking effective measures to reduce the self-perceived burden of patients through the joint efforts of the government, the hospital and the family can alleviate their reproductive concern.

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The influence of learning style characteristics on the effect of laparoscopic camera navigation training

ZHAI Bo, ZHU Qiankun, LI Xiaodong, HU Fengli, JIN Xin

Journal of Hebei Medical College for Continuing Education 2022, 39 (3): 74-80. DOI: 10.3969/j.issn.1674-490X.2022.03.012

Abstract （261）

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Objective To analyze the learning styles of medical students and explore the influence of different learning styles on the training of laparoscopic camera navigation training. Methods Before the laparoscopic camera navigation training of camera assistants, 60 interns and 40 postgraduates were assessed with Kolb learning style scale; then the differences of learning style characteristics between interns and postgraduates were analyzed and compared, as well as the influence of different learning style characteristics on the laparoscopic camera navigation training. Results There were significant differences in learning styles characteristics between interns and postgraduates(P<0.001). In the Intern Group, the diverging learning style is the main one, while in the postgraduate group, the converging learning style is the main one(P<0.001). Learning style characteristics have a significant impact on the effect of laparoscopic camera navigation training. The average number of errors in each cycle of centering, neutral horizon and optimum distance of interns and postgraduates with the converging learning style were significantly less than those with diverging, assimilating and accommodating learning styles(P<0.001). Conclusion There are significant differences among medical students in learning style characteristics. Learning style characteristics have a significant impact on the training effects in laparoscopic camera navigation training. In medical education, we should give full consideration to the differences in learning style characteristics, and give full play to the advantages of students' learning styles.

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Effect of RG108 on proliferation and gene expression of HT22 cell line

JIANG Le,WANG Xiaobing,HE Ershu,ZHENG Xiaoye,GONG Zhiting

Journal of Hebei Medical College for Continuing Education 2022, 39 (4): 1-7. DOI: 10.3969/j.issn.1674-490X.2022.04.001

Abstract （301）

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Objective To investigate the effect of DNA methyltransferase inhibitor RG108,on HT22 cells,a mouse hippocampal neuronal cell line cultured in vitro.Methods HT22 hippocampal neuronal cells cultured in vitro were treated with DNA methyltransferase inhibitor RG108 at concentrations of 0.5,5,and 50 μmol/L,and the cell viability was detected with CCK-8,and the expression of middle and downstream genes in the cells was detected using RT-qPCR.Results CCK-8 assay showed that 50 μmol/L RG108 could promote the proliferation of HT22 cells after 48 and 72 hours and the difference was statistically significant(P<0.05).RT-qPCR results demonstrated that the expression of synaptic plasticity-related genes nr1 and reln decreased in HT22 cells treated with 50 μmol/L RG108,and the difference was statistically significant(P<0.05).Conclusion DNA methyl transferase inhibitor RG108 can promote the proliferation of mouse hippocampal cell line HT22 cells and regulate the expression of neuroplasticity-related genes.Moreover,RG108 may affect synaptic plasticity,which may influence synaptic plasticity-related behaviors such as memory formation.

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Advances on pathophysiological mechanism of postoperative delirium in elderly patients

GAO Qi,SUN Tianpei,WU Guangyi

Journal of Hebei Medical College for Continuing Education 2022, 39 (4): 8-13. DOI: 10.3969/j.issn.1674-490X.2022.04.002

Abstract （346）

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Postoperative delirium(POD)is characterized by decreased attention,consciousness and cognitive disorders and perceptual disorders.It tends to occur in elderly patients,and is closely related to prolonged hospital stay,increased economic burden,reduced quality of life and increased postoperative mortality.At present,the pathophysiology and pathogenesis of POD have not been fully defined,and there are no effective biological and clinical indicators,which affects the early diagnosis and prevention of POD to a certain extent.This paper reviews the pathogenesis of POD in recent years in order to have a clearer understanding of POD from the physiological mechanism and provide more effective methods for the prevention and treatment of POD in clinic.

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Effect of enhanced sensory stimulation-oriented facilitation technique in the rehabilitation of upper limb function after stroke

XIE Ruijuan, DENG Yun, LIU Juan, YANG Nan,ZHANG Kun

Journal of Hebei Medical College for Continuing Education 2022, 39 (4): 14-21. DOI: 10.3969/j.issn.1674-490X.2022.04.003

Abstract （286）

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Objective To explore the influence of strengthening facilitation technique guided by sensory stimulation on the rehabilitation effect of upper limb function in stroke patients on occupational therapy. Methods Sixty patients with paraplegia and spasms during stroke that were treated in our department from June 2018 to May 2020 were selected as the subjects of the study. These patients were divided into therapy group(n=30)and control group(n=30). Both groups received routine rehabilitation on this basis. The therapy group were given strenghening facilitation techniques such as Brunnstrom technique, Bobath technique, Rood technique, PNF(propriceptive neuromuscular facilitation)technique, especially strengthening the application of the sense of stimulation ingredients to stimulate multi-sensory paths such as visual hearing, shallow sensations, ontogenal sensations, composite sensations and by password, brushing, tapping, pressing, extrusion, stretching, cold water, warm water, resistance, control and other measures, the treatment period was 12 weeks. Fugl-Meyer Assessmont Scnle(FMA)-upper limb was used to examine the rate the motor function of 2 groups of patients before and 6 weeks and 12 weeks after treatment. Ability of ADL(activities of daily living)was scored in 2 groups of patients before and 6 weeks and 12 weeks after treatment using an improved Barthel index scale(modified Barthel index, MBI). In strumental ADL ability 2 groups half a year after discharge using Functional Activity Questionnaires(FAQ), the Brunnstrom stage was used to determine the rate the proportion of partial separation exercise period and separation exercise period at 12 weeks of treatment in 2 groups. Results 2 groups after 6 weeks and 12 weeks had significant effects compared to pre-treatment,and the exercise ability and ADL ability of the therapy group were better than that of the control group, the exercise ability and ADL ability of the two groups after 12 weeks were better than those of the group after 6 weeks(all P<0.01). In strumental ADL ability of the therapy group was better than that of the control group(P<0.01). In 2 groups half a year after discharge, there were significantly more cases of patients with upper limb movement function recovery up to Brunnstrom 4 and above treatment group than in 2 groups(all P<0.01), it was shown that strengthening sensory stimulation in rehabilitation training could enable the patients to obtain better rehabilitation results. Conclusion The use of facilitation technique in occupational therapy, especially the strengthening of the sensational stimulation component of facilitation technique, can significantly promote the process of motor function rehabilitation in patients with paraplegia with stroke paraplegia, significantly improve the movement function of the upper limbs of patients, and improve ADL ability.

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Development on digital orthopedic technology in clinical work

YANG Xuping, LI Xingyong

Journal of Hebei Medical College for Continuing Education 2022, 39 (4): 22-29. DOI: 10.3969/j.issn.1674-490X.2022.04.004

Abstract （418）

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Digital medicine is an emerging discipline that combines scientific informatics with medical technology, including 3D printing, finite element analysis and computer-aided orthopedic technology, and its application in the field of orthopedics is very extensive. Based on the many advantages of digital orthopedic technology in clinical work, it helps to solve the difficulties encountered in clinical work and has considerable application prospects, and its effective application in the clinic can benefit the majority of patients.

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Advances on artificial intelligence in the diagnosis and treatment of urinary calculi

ZHAN Xiaofei, CUI Zhenyu, ZHAO Chunli

Journal of Hebei Medical College for Continuing Education 2022, 39 (4): 30-38. DOI: 10.3969/j.issn.1674-490X.2022.04.005

Abstract （352）

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As healthcare systems continue to digitize and medical data continue to increase, clinicians face significant challenges in making accurate diagnoses, developing personalized treatment plans, and determining prognoses. There are some problems such as unknown formation factors, complex components, and large anatomical differences in the occurrence sites of urinary calculi, which hinder the personalized diagnosis and treatment of patients with calculi. Artificial intelligence can flexibly analyze and learn different data types, providing new ideas for the accurate diagnosis and treatment of urinary calculi. This paper reviews the research content of artificial intelligence in the diagnosis and treatment of urinary calculi to improve the understanding of the application of artificial intelligence in the diagnosis and treatment of urinary calculi.

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Developments on telemedicine in management of senile hypertension

HUANG Shengnan,ZHAO Rui,XIAO Nuan

Journal of Hebei Medical College for Continuing Education 2022, 39 (4): 39-44. DOI: 10.3969/j.issn.1674-490X.2022.04.006

Abstract （413）

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Essential hypertension is one of the most common chronic diseases in the elderly, and it is also the most common risk factor of acute cardiovascular and cerebrovascular diseases.As a new hypertension management model, telemedicine plays an important role in medication compliance and hypertension control rate of patients with hypertension.This paper summarizes telemedicine and its concept in the management of senile hypertension, the application status of telemedicine in the management of senile hypertension and the suggestions to speed up the development of telemedicine management model.

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HAO's clinical experience of traditional Chinese medicine in Baoding in ophthalmology

MENG Hongwei

Journal of Hebei Medical College for Continuing Education 2022, 39 (4): 45-54. DOI: 10.3969/j.issn.1674-490X.2022.04.007

Abstract （767）

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HAO's ophthalmology of traditional Chinese Medicine(TCM)is the specialty of TCM in Baoding. HAO Dexin is a renowned Chinese ophthalmologist at the Hebei Institute of Traditional Chinese Medicine in Baoding in ancestral ophthalmology.HAO is a representative of traditional Chinese medicine ophthalmology.He has rich experience in diagnosis and treatment of diseases such as fulminant blindness, myopia and fundus oculi diseases.The curative effect is remarkable.HAO is good at treating eye diseases with traditional Chinese medicine and acupuncture.He has unique experience in the application of Chinese medicine prescription and the manipulation of acupoints.The diagnosis and treatment of ophthalmologic diseases should be based on the three Jing of Xin,Gan and Shen.

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