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Advances on determination methods of flavonoids in Chinese herbal medicine YANG Hui,YANG Tianrun,MA Ziyun Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 9-13.   DOI: 10.3969/j.issn.1674-490X.2022.03.002 Abstract （683）      PDF（pc） （436KB）（501）       Knowledge map    Save Flavonoids are a kind of natural organic compounds widely existing in plants and are abundant in many Chinese herbal medicines. As an effective component of many traditional Chinese medicines, flavonoids play an important role in the treatment of diseases due to their extensive physiological or pharmacological activities, and are widely used in clinical practice. Therefore, the determination of such compounds in Chinese herbal medicine is one of the important links in drug quality control. In this paper, different determination methods of flavonoids in Chinese herbal medicine are reviewed. Reference | Related Articles | Metrics | Comments（0）

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Current situation and development strategy of community hospice care in China JIN Yan, QIAO Yanhua Journal of Hebei Medical College for Continuing Education    2022, 39 (1): 54-60.   DOI: 10.3969/j.issn.1674-490X.2022.01.008 Abstract （666）      PDF（pc） （489KB）（496）       Knowledge map    Save By combing the development model and experience of community hospice care in China, this paper analyzes the main problems existing in the development of community hospice care, and puts forward reasonable suggestions for the development of community hospice care in China, such as increasing support and guarantee, strengthening the construction of talent team, establishing a correct concept of life and death so as to promote the faster and better development of domestic community hospice care services. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (6): 36-43.   DOI: 10.3969/j.issn.1674-490X.2021.06.006 Abstract （363）      PDF（pc） （515KB）（387）       Knowledge map    Save Osteoporosis is a skeletal disease which is susceptible to middle-aged and elderly people. It is characterized by decreased bone density, destruction of bone microstructure, increased bone fragility, and prone to fractures.Drug therapy is an important means to effectively prevent osteoporosis and reduces fractures, but there are problems such as long treatment period and adverse drug reactions. However, physical therapy has the advantages of outstanding curative effect and low side effects. This review mainly describes the application of physical therapy in the treatment of osteoporosis, aiming to provide a basis for clinically formulating high-quality rehabilitation strategies for prevention and treatment of osteoporosis. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (4): 8-17.   DOI: 10.3969/j.issn.1674-490X.2021.04.002 Abstract （602）      PDF（pc） （771KB）（383）       Knowledge map    Save Coronary artery bifurcation lesions are common in coronary intervention. Due to the greatly individual differentiation of coronary artery bifurcation lesions, complex surgical procedures, high intraoperative risk, many postoperative complications, and poor long-term prognosis, a standard process is hard to follow to solve all bifurcation lesions. The classification rules, evaluation methods, and treatment strategies of coronary bifurcation lesions are systematically reviewed in order to get more comprehensively understanding of coronary bifurcation lesions. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (4): 73-80.   DOI: 10.3969/j.issn.1674-490X.2021.04.011 Abstract （591）      PDF（pc） （483KB）（379）       Knowledge map    Save This article reviews the current status of HPV vaccination, the theoretical framework and intervention methods of HPV vaccination intervention. It is recommended that future studies build a multi-level social support system(including government level, medical staff level and parent level, etc.)based on internet technology, and enrich publicity methods(narrative dissemination)to improve the health awareness and health behaviors of the age-appropriate population for HPV vaccination and prevent HPV infection. Reference | Related Articles | Metrics | Comments（0）

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Role of binocular vision function in the progression of myopia GAO Chunting, YUAN Hui, DU Junhui Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 14-20.   DOI: 10.3969/j.issn.1674-490X.2022.03.003 Abstract （392）      PDF（pc） （476KB）（348）       Knowledge map    Save Myopia is a common disease in the population, and its incidence is increasing year by year, especially in children and adolescents, seriously affecting their physical and mental health. Binocular vision refers to that two eyes see at the same time, while external objects fall on the retina, forming retinal images, nerve excitatory transmission go to the brain higher center, so that the visual signals of two eyes merge into a single perceptual object. When viewing stereoscopic objects, due to the difference of normal pupil distance and the angle of faxation, the images formed on the retina of the two eyes are not completely symmetrical and have certain horizontal difference. This phenomenon is called Binocular Parallax, which gives us stereoscopic perception. Many studies have shown that binocular vision functions such as accommodation, convergence, stereoscopic vision and the development of myopia interact.The purpose of this article is to review the developments of binocular vision function and myopia in order to provide reference for the prevention and control of myopia to choose effective and appropriate programs. Reference | Related Articles | Metrics | Comments（0）

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HAO's clinical experience of traditional Chinese medicine in Baoding in ophthalmology MENG Hongwei Journal of Hebei Medical College for Continuing Education    2022, 39 (4): 45-54.   DOI: 10.3969/j.issn.1674-490X.2022.04.007 Abstract （560）      PDF（pc） （515KB）（341）       Knowledge map    Save HAO's ophthalmology of traditional Chinese Medicine(TCM)is the specialty of TCM in Baoding. HAO Dexin is a renowned Chinese ophthalmologist at the Hebei Institute of Traditional Chinese Medicine in Baoding in ancestral ophthalmology.HAO is a representative of traditional Chinese medicine ophthalmology.He has rich experience in diagnosis and treatment of diseases such as fulminant blindness, myopia and fundus oculi diseases.The curative effect is remarkable.HAO is good at treating eye diseases with traditional Chinese medicine and acupuncture.He has unique experience in the application of Chinese medicine prescription and the manipulation of acupoints.The diagnosis and treatment of ophthalmologic diseases should be based on the three Jing of Xin,Gan and Shen. Reference | Related Articles | Metrics | Comments（0）

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Advances on radiomics in adrenal adenoma WU Chunmei, YIN Xiaoping Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 29-34.   DOI: 10.3969/j.issn.1674-490X.2022.03.005 Abstract （284）      PDF（pc） （426KB）（305）       Knowledge map    Save Adrenal adenoma is a common tumor in clinical practices. At present, initial progress has been made in the identification of adrenal benign and malignant tumors, functional adrenal adenoma subtypes, lipid adenoma and pheochromocytoma. Studies on adrenal adenoma are mainly carried out through texture analysis and histogram analysis, which can effectively evaluate tumor atypia and provide effective help in clinical decision-making.In addition, the normogram model combining clinical features and imaging features has a good identification effect for functional adrenal adenoma subtypes. The purpose of this article is to review the current status, problems and prospects of imaging in the diagnosis and differential diagnosis of adrenal adenoma, and the prediction, monitoring and prognosis of treatment strategies. Reference | Related Articles | Metrics | Comments（0）

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Challenges and countermeasures of population aging to public health service CHENG Huaizhi, GUO Bin, SONG Jiawei, LI Yu Journal of Hebei Medical College for Continuing Education    2022, 39 (1): 49-53.   DOI: 10.3969/j.issn.1674-490X.2022.01.007 Abstract （1022）      PDF（pc） （430KB）（297）       Knowledge map    Save China is facing a huge medical challenge from its aging problem. By 2050, China's population aged 65 and above will reach 400 million, of which the population aged 80 and above will reach 150 million. This paper reviews the evolution and current situation of population aging systematically through literature review, and analyzes some public health problems caused by China's aging population from the perspective of economic: underutilization of health service, the rapid rise of health costs, the huge demand for nursing service. It is suggested that we should strengthen health education for the elderly, expand nursing service, provide individual nursing care for them, further improve the medical security system and build a sustainable long-term care insurance system. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (3): 62-69.   DOI: 10.3969/j.issn.1674-490X.2021.03.011 Abstract （621）      PDF（pc） （963KB）（291）       Knowledge map    Save Objective To analyze the research hotspot, frontier and future development trends in the field of nursing psychology in the past six years, and provide reference suggestions for the development and application of related research in the field of nursing psychology.Methods Through the CNKI database, using “psychology” as the search term, retrieve the papers published in ten core nursing journals from 2015 to 2020, and use the CiteSpace visualization software to perform metrological analysis of authors, institutions, and keywords.Results A total of 2 341 papers on nursing psychology published in ten core nursing journals from 2015 to 2020 were included.The number of papers published in the past 6 years has shown a slight fluctuation trend.The publishing organizations are relatively concentrated, mostly from major universities, and there is little cooperation between authors.Key words such as qualitative research,quality of life, influencing factors, and have been the research hotspots of nursing psychology in the past six years, and ICU Nurses,psychological distress,psychological perplexity and mediation effect are the research frontiers.Conclusion Visualized analysis of nursing psychology papers published in core nursing journals in the past six years can help us to understand the research hotspot and frontier trends of nursing psychology related research, and promote the further development of nursing psychology research in teaching, clinical, and management levels. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (3): 1-6.   DOI: 10.3969/j.issn.1674-490X.2021.03.001 Abstract （412）      PDF（pc） （439KB）（286）       Knowledge map    Save Umbilical cord blood has gradually become an important source of stem cells in allogeneic stem cell transplantation.Although the post-transplantation infective fatality rate is higher, the survival rate of cord blood transplantation is comparable to other types of stem cell transplantation due to the advantages of easy access and lower incidence of GVHD(graft-versus-host diseases, GVHD).The improvement of cord blood transplantation technology has also brought better curative effect to the patients. The clinical application of umbilical cord blood provides a new method for the treatment of many refractory diseases.This article reviews the improvement of cord blood transplantation in recent years, the selection of cord blood for transplantation and the application of umbilical cord blood in other related diseases. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (4): 61-66.   DOI: 10.3969/j.issn.1674-490X.2021.04.009 Abstract （434）      PDF（pc） （441KB）（282）       Knowledge map    Save This study introduced the concept of “Internet plus” and hospice care, analyzed the advantages of application of “Internet plus” in the field of hospice care, and synthesized the use of “Internet plus” in symptoms management, psychological and social support, education and information provision for hospice patients, and information support and work coordination for health professionals, and summarized the problems and development prospects, with the purpose of providing reference for the development and application of “Internet + hospice care” service delivery model in China. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (3): 70-80.   DOI: 10.3969/j.issn.1674-490X.2021.03.012 Abstract （405）      PDF（pc） （1519KB）（274）       Knowledge map    Save Objective To analyze the international research status of self-compassion in recent 11 years, so as to understand the research basis, hot spots and frontier of self-compassion related literature, help nursing and educators to enhance their understanding of self-compassion, and provide basis for further improving nursing and teaching concepts.Methods Using the core collection of web of science database as the platform, CiteSpace software was used to analyze the self compassion literatures collected from January 2010 to June 2020.Results A total of 1 677 articles were searched, and the number of published articles increased year by year.The research level of nursing and education should be improved, Classic literature on self compassion focuses on self compassion theory, intervention methods and scale research.The research focuses are self-compassion theory research, intervention measures and scale use.The future research frontier is randomized controlled trials of self-compassion measurement and interventionmethods in different types of people.Conclusion Self-compassion as a positive psychological quality, and its measurement and intervention are important ways to improve the level of individual mental health.In the future nursing and teaching work, we should pay attention to measuring the level of self-compassion of different groups, and formulate intervention strategies to improve the level of self-compassion as the core in nursing work and daily teaching, so as to enhance the quality of nursing and teaching. Reference | Related Articles | Metrics | Comments（0）

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Current status of research on clinical progress management of benign prostatic hyperplasia JIANG Dongxu, ZOU Hao, SUN Min, ZHANG Linlin Journal of Hebei Medical College for Continuing Education    2022, 39 (1): 68-74.   DOI: 10.3969/j.issn.1674-490X.2022.01.010 Abstract （294）      PDF（pc） （469KB）（272）       Knowledge map    Save In recent years,with the acceleration of aging,the prevalence of benign prostatic hyperplasia(BPH)has shown an increasing trend,seriously affecting the quality of life of elderly men,and at the same time,it has brought an economic burden to the global medical care service system. In order to explore the current status of BPH management methods at home and abroad,an integrated analysis was carried out by searching relevant literature on BPH clinical progress management. At present,in order to delay and change the clinical progress of BPH patients,management methods combining clinical and non-clinical interventions have been adopted at home and abroad,and some results have been achieved,but there are still certain limitations. This paper analyzes and summarizes the current research status, and provides a reliable basis for the management of BPH clinical progress in the later stage. Reference | Related Articles | Metrics | Comments（0）

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Discussion on improving community home-based elderly care model based on appreciative inquiry SHANG Dongxu, LU Xiangyu, WANG Xinxin, WANG Lina, GUO Yufang Journal of Hebei Medical College for Continuing Education    2022, 39 (1): 61-67.   DOI: 10.3969/j.issn.1674-490X.2022.01.009 Abstract （258）      PDF（pc） （489KB）（259）       Knowledge map    Save The community home-based elderly care model is one of the elderly care models vigorously implemented in China. However, due to the particularity of the elderly group, there are some problems in the implementation of the community home-based elderly care model, such as the shortage of medical resources, the low degree of specialization and cooperation of service personnel, the poor interaction of multiple information, and the incomplete expression of the needs of the elderly. As a new way of organizational change, appreciative inquiry provides new ideas to solve the above problems. From the perspective of realizing the goal of appreciative inquiry, this paper puts forward relevant suggestions to improve the community home-based elderly care model in order to provide reference for improving the community home-based elderly care model. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (6): 27-35.   DOI: 10.3969/j.issn.1674-490X.2021.06.005 Abstract （410）      PDF（pc） （490KB）（253）       Knowledge map    Save Lung cancer is the most common cancer and the leading cause of cancer death worldwide. Early diagnosis of lung cancer can reduce mortality. Radiomics can extract the quantitative features of the images by computer software to explore more disease information of lung cancer and improve the early diagnosis rate. This article reviews the application of imaging omics in the early diagnosis of lung cancer in order to improve the understanding of the application of radiomics in the diagnosis of lung cancer. Reference | Related Articles | Metrics | Comments（0）

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The key role of Nrf2 in ischemic stroke ZHU Jianping, LI Yunman Journal of Hebei Medical College for Continuing Education    2022, 39 (2): 1-9.   DOI: 10.3969/j.issn.1674-490X.2022.02.001 Abstract （347）      PDF（pc） （693KB）（246）       Knowledge map    Save Ischemic stroke is one of the main causes of death and disability worldwide. Nuclear factor E2-related factor 2(Nrf2)is an important transcription factor that regulates the balance of the body's redox reaction. It participates in resisting endogenous or exogenous stress by coordinating a variety of cytoprotective genes. The Nrf2 signaling pathway not only strictly regulates the body's redox homeostasis, but also participates in the regulation of multiple processes in the body metabolism. Therefore, targeting Nrf2 has become a potential strategy for the prevention and treatment of central nervous system diseases including ischemic stroke. In this review, we first introduced the structural features of Nrf2 and Kelch-like ECH-related protein 1(Keap1), and briefly described the activation and regulation of the Nrf2 pathway. Next, we discussed the pathological and physiological mechanism, upstream regulators and downstream targets of the Nrf2 pathway. In this context, we extended the discussion to the role of Nrf2 after ischemic stroke and explored potential therapeutic directions. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (4): 67-72.   DOI: 10.3969/j.issn.1674-490X.2021.04.010 Abstract （361）      PDF（pc） （414KB）（246）       Knowledge map    Save 6S model is a practical concept in hospice care, the essence is person-centered palliative and it's aim is to promote patients' death with dignity. It has been verified that it could be applied to many aspects of nursing work to help patients and nurses. This model can provide some reference and guidance for promoting the domestic hospice care in the exploratory stage. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (6): 69-73.   DOI: 10.3969/j.issn.1674-490X.2021.06.010 Abstract （249）      PDF（pc） （423KB）（242）       Knowledge map    Save This paper summarizes the common unhealthy psychological characteristics of the elderly living in the pension institutions and the psychological needs of the elderly under the pension model of the pension institutions, which also discusses the importance of improving the quality of life and well-being of the elderly through the establishment of targeted and accurate nursing countermeasures, so as to provide a reference for the model of the nursing work of the pension institutions in the future. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (5): 51-58.   DOI: 10.3969/j.issn.1674-490X.2021.05.008 Abstract （277）      PDF（pc） （517KB）（237）       Knowledge map    Save Objective To clarify the concept of reproductive concerns among cancer patients through systematic analyzing of the development, attributes, cases, antecedents, and consequences of the concept of reproductive concerns among cancer patients.Methods Literature on reproductive concerns among cancer patients from the establishment of the database to March 4, 2021 were retrieved from CNKI, Wanfang, VIP, PubMed, Web of Science, PsycInfo, Walker and Avant's concept analysis method was used to analyze the connotation.Results By analyzing the relevant literature,the three concept attributes of the reproductive concerns among cancer patients were summarized:excessive cognition of fertility uncertainty; negative emotional reactions such as anger, guilt, and worry; conflicts between cancer and treatment and family fertility planning.Conclusion A systematic analysis of the concept of reproductive concerns among cancer patients can help medical staff to better identify the reproductive concerns among cancer patients during the process of diagnosis, treatment and nursing, and reduce their reproductive concerns to improve their quality of life through corresponding intervention measures. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (6): 8-14.   DOI: 10.3969/j.issn.1674-490X.2021.06.002 Abstract （312）      PDF（pc） （457KB）（232）       Knowledge map    Save Intestinal flora is currently a hot issue studied by scholars around the world. The structure and composition of intestinal flora will change after ischemic stroke, which may threaten the life and health of people after stroke. Intestinal flora affects the progression of the disease by increasing the production of pro-inflammatory cytokines and intestinal permeability. Through the flora and stroke-related inflammatory response, the changes in the intestinal flora of patients after ischemic stroke, the impact of the flora on the complications of stroke, and the possibility of the current intestinal flora for clinical treatment, the progress of the intestinal flora and ischemic stroke were reviewed. In the process of clinical diagnosis and treatment, the influence of intestinal flora should be considered so as not to affect the diagnosis and treatment of the disease. Reference | Related Articles | Metrics | Comments（0）

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Developments on risk factors of complications in joint replacement HE Zhenqiang,ZHU Lin,PANG Jingwen,YIN Xiujuan,JIAO Jianbao Journal of Hebei Medical College for Continuing Education    2022, 39 (1): 15-24.   DOI: 10.3969/j.issn.1674-490X.2022.01.003 Abstract （217）      PDF（pc） （507KB）（229）       Knowledge map    Save With the acceleration of China's aging process, the incidence of chronic bone and joint diseases is increasing year by year, and one of the most effective treatments is total joint arthroplasty. At present, total joint arthroplasty has been widely used in clinic, but some patients still have complications. Because the preoperative factors of total joint arthroplasty can affect the incidence of postoperative complications, by improving the preoperative risk factors, we can provide the patients with artificial joint replacement with the best operation opportunity and reduce the incidence of surgical complications. This paper introduces the influence of common preoperative risk factors of total joint arthroplasty on the incidence of postoperative complications, hoping to provide some guidance for orthopedic surgeons in preventing postoperative complications. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2023, 40 (4): 1-10.   DOI: 10.3969/j.issn.1674-490X.2023.04.001 Abstract （266）      PDF（pc） （830KB）（223）       Knowledge map    Save As a hormone secreted by white fat cells, leptin acts as a peripheral signal linking adipose tissue and the central nervous system networks, affecting feeding, energy balance, endocrine and immune functions. Through the analysis and summary of molecular structure and intracellular distribution of leptin and its receptor(LEPR), the recent developments on the regulation of lipid metabolism, inflammation and immunity, wound healing and tumor development are reviewed. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (6): 74-80.   DOI: 10.3969/j.issn.1674-490X.2021.06.011 Abstract （303）      PDF（pc） （635KB）（221）       Knowledge map    Save Objective To explore the application of the network-based Problem-based learning(PBL)combined with Multiple Disciplinary Team(MDT)mode in teaching medical undergraduate students during the Covid-19 epidemic to provide new suggestions for the teaching mode of medical undergraduates. Methods 117 clinical medicine undergraduates of grade 2018 in China Medical University were selected as the research objects and divided randomly into control group(61)and experimental group(56). The control group was taught by network PBL teaching,and the experimental group was taught by network-based PBL combined with MDT teaching Mode. At the end of the teaching, the case-studied summary and the satisfaction of the teaching mode of the two groups were analyzed. Results The questionnaire survey found that PBL+MDT teaching group's case-studied summary and the improvement of self-ability was significantly higher than that of the control group, the difference was statistically significant(P<0.05). Students' satisfaction of PBL+MDT teaching was higher, the difference was statistically significant(P<0.05). Conclusion Network-based PBL combined with MDT mode can improve the enthusiasm of medical undergraduates, cultivate students' evidence-based thinking and innovation ability, and have a positive effect on the training of medical undergraduates. Reference | Related Articles | Metrics | Comments（0）

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Application progress of Snyder's hope theory in the nursing of chronic non-malignant patients PANG Lin, JING Kunjuan Journal of Hebei Medical College for Continuing Education    2022, 39 (2): 48-53.   DOI: 10.3969/j.issn.1674-490X.2022.02.007 Abstract （243）      PDF（pc） （461KB）（220）       Knowledge map    Save Chronic non-malignant diseases refer to other chronic diseases other than cancer, which cause serious psychological burden to patients and their families due to the persistence of the disease. Hope, as an inner psychological force, can enhance the patient's self-confidence in the face of the disease. This paper introduces the connotation of Snyder's theory of hope, summarizes and analyzes the influencing factors of the hope level of chronic non-malignant patients and the application status of hope theory in the nursing of chronic non-malignant patients, and provides a reference for the development of targeted intervention measures for chronic non-malignant patients. Reference | Related Articles | Metrics | Comments（0）

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Effect of RG108 on proliferation and gene expression of HT22 cell line JIANG Le,WANG Xiaobing,HE Ershu,ZHENG Xiaoye,GONG Zhiting Journal of Hebei Medical College for Continuing Education    2022, 39 (4): 1-7.   DOI: 10.3969/j.issn.1674-490X.2022.04.001 Abstract （221）      PDF（pc） （809KB）（219）       Knowledge map    Save Objective To investigate the effect of DNA methyltransferase inhibitor RG108,on HT22 cells,a mouse hippocampal neuronal cell line cultured in vitro.Methods HT22 hippocampal neuronal cells cultured in vitro were treated with DNA methyltransferase inhibitor RG108 at concentrations of 0.5,5,and 50 μmol/L,and the cell viability was detected with CCK-8,and the expression of middle and downstream genes in the cells was detected using RT-qPCR.Results CCK-8 assay showed that 50 μmol/L RG108 could promote the proliferation of HT22 cells after 48 and 72 hours and the difference was statistically significant(P<0.05).RT-qPCR results demonstrated that the expression of synaptic plasticity-related genes nr1 and reln decreased in HT22 cells treated with 50 μmol/L RG108,and the difference was statistically significant(P<0.05).Conclusion DNA methyl transferase inhibitor RG108 can promote the proliferation of mouse hippocampal cell line HT22 cells and regulate the expression of neuroplasticity-related genes.Moreover,RG108 may affect synaptic plasticity,which may influence synaptic plasticity-related behaviors such as memory formation. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2023, 40 (2): 58-65.   DOI: 10.3969/j.issn.1674-490X.2023.02.009 Abstract （456）      PDF（pc） （478KB）（204）       Knowledge map    Save As a chronic lifelong disease, the long-term disease management of diabetes predisposes patients to increase physical and psychological burdens, resulting in negative psychological distress, which affects patients' disease progression and quality of life. This article reviews the current status of psychological distress in diabetes, psychological distress assessment tools and influencing factors, and presents its own reflections to provide a reference for identifying, preventing and implementing targeted interventions for psychological distress in diabetes, and to point out the way for future related research. Reference | Related Articles | Metrics | Comments（0）

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Prospect of treatment of retinal vein edema combined with macular edema HAO Jianzhang, ZHANG Hu Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 35-40.   DOI: 10.3969/j.issn.1674-490X.2022.03.006 Abstract （245）      PDF（pc） （453KB）（201）       Knowledge map    Save Retinal vein occlusion(RVO)is the most common retinal vascular disease and one of the most common causes of blindness. The incidence of RVO increases with age. Most patients are over 65 years old, but the age of onset of the disease is also getting younger because of changes in the Chinese diet. Macular edema, often accompanied by retinal vein occlusion, is also a major cause of vision loss in patients with the disease.At present, there are many treating approaches for the patients with retinal vein occlusion combined with macular edema. Each method has its different effects due to the individual differences of the patients. To date, different treatment schemes are conducted according to the patients' own conditions, and most of them are combined with several treatment methods. By consulting relevant literatures and personal experience in the process of treating patients, the author summarizes and discusses the prospects of the treatment methods, curative effects, prognosis and costs of retinal vein occlusion complicated with macular edema, so as to find potential problems and influencing factors and explore the best clinical treatment regimen. Reference | Related Articles | Metrics | Comments（0）

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Reproductive concern status and its influencing factors in gynecological cancer patients XU Li,LIU Wenjuan,ZHANG Li Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 67-73.   DOI: 10.3969/j.issn.1674-490X.2022.03.011 Abstract （194）      PDF（pc） （482KB）（200）       Knowledge map    Save Objective To understand the level of reproductive concern in gynecological cancer patients, and explore its status and influencing factors. Methods Reproductive Concerns after Cancer Scale(RCACs)and Self-perceived Burden Scale for Cancer Patients(SPBS-CP)were collected from 134 gynecologic cancer patients. Results Average RCAC score in gynecological cancer patients was 48.88±13.59.SPBS-CP score was 50.92±17.38.There were differences in reproductive concern levels among patients in different groups(age, willingness to bear children, number of children, content of communication, and self-perceived burden level)(P<0.01).Self-perceived burden and all dimensions were positively correlated with reproductive concern(P< 0.01). After multiple linear regression analysis:Fertility willingness and self-perceived burden were important independent influencing factors of reproductive concern in gynecological cancer patients(P< 0.01).Conclusion Gynecological cancer patients reproductive concern is above medium level. Attention should be paid to those with reproductive needs and heavy self-perceived burden. Taking effective measures to reduce the self-perceived burden of patients through the joint efforts of the government, the hospital and the family can alleviate their reproductive concern. Reference | Related Articles | Metrics | Comments（0）

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Advances on recurrence of secondary hyperparathyroidism after parathyroidectomy JIN Qiu, LIANG Yulong Journal of Hebei Medical College for Continuing Education    2022, 39 (1): 41-48.   DOI: 10.3969/j.issn.1674-490X.2022.01.006 Abstract （267）      PDF（pc） （471KB）（198）       Knowledge map    Save Disturbance of calcium and phosphorus metabolism in chronic renal failure patients with long-term dialysis can cause compensatory hyperplasia of parathyroid gland and the increase of intact parathyroid hormone(iPTH)known as renal hyperparathyroidism(HPT)or secondary hyperparathyroidism(SHPT),clinical manifestations can include high parathyroidin, high calcium or hypocalcemia, and persistent high phosphorus. It can lead to diseases of skeletal system, neuropsychiatric system, blood system and cardio-cerebrovascular system, seriously affecting the quality of life and life span. The 2017 Global Guidelines for Kidney Disease recommend Chronic Kidney Disease(CKD)stage 3-5 complicated with severe hyperparathyroidism that does not respond to drug therapy, and parathyroidectomy is recommended. The problem of postoperative recurrence rate affects the further promotion of surgery. Although ultrasound and radionuclide scanning techniques have become more sophisticated in the past few years, it is still not possible to ensure complete preoperative localization of all parathyroids, especially those with less hyperplasia. The recurrence rate of subtotal resection and total resection plus autologous transplantation is higher than that of total resection, so total resection is more recommended for the prevention of recurrence. In addition, the improvement of preoperative localization, thymotomy, intraoperative parathyroid hormone monitoring and intraoperative nerve monitoring also contributed to the reduction of postoperative recurrence. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2023, 40 (1): 1-9.   DOI: 10.3969/j.issn.1674-490X.2023.01.001 Abstract （138）      PDF（pc） （1228KB）（194）       Knowledge map    Save Objective To investigate the effect of ginsenoside Rg1 on the proliferation of adriamycin(ADR)-resistant K562/ADR cells in human chronic myeloid leukemia(CML)and its reversal of drug resistance in K562/ADR cells. Methods CCK-8 assay was used to detect the effects of different concentrations of ginsenoside Rg1 on the proliferation of K562/ADR cells. CCK-8 assay was used to detect the effects of ginsenoside Rg1 combined with ADR on the proliferation of K562/ADR cells, and the half maximal inhibitory concentration(IC50)and reversal fold were calculated. Colony formation assay was used to detect the effects of ginsenoside Rg1 combined with ADR on the colony formation ability of K562/ADR cells. Flow cytometry was used to detect the effects of ginsenoside Rg1 combined with ADR on the cell cycle of K562/ADR cells. Results Compared with the control group, the proliferation inhibition rate of K562/ADR cells treated with 120 μg/ml ginsenoside Rg1 for 48 h was significantly increased(P<0.001). Compared with the ADR alone group, the IC50 value of ginsenoside Rg1 combined with ADR for 48 h decreased significantly in K562/ADR cells(P<0.05), and the fold reversal of ginsenoside Rg1 resistance to K562/ADR cells was 2.34. Compared with the control group and ADR or ginsenoside Rg1 alone group, ginsenoside Rg1 combined with ADR could significantly inhibit K562/ADR cell colony formation(P<0.05). Compared with the ADR or ginsenoside Rg1 alone group, ginsenoside Rg1 combined with ADR could arrest the cell cycle in G0/G1 phase. Conclusion Ginsenoside Rg1 combined with ADR can significantly inhibit the proliferation of K562/ADR cells and reverse the resistance of K562/ADR cells to ADR, which may be related to the cell cycle arrest in G0/G1 phase. Reference | Related Articles | Metrics | Comments（0）

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Simple obesity and application of TCM Piwei theory ZHANG Jinghui,ZHAO Hanqing,WANG Zewen,XIANG Hongwei,GE Shaoqin Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 54-59.   DOI: 10.3969/j.issn.1674-490X.2022.03.009 Abstract （235）      PDF（pc） （453KB）（191）       Knowledge map    Save Simple obesity refers to obesity without obvious disease inducement, which is caused by genetic factors and environmental factors.Clinical practice shows that the TCM treatment of simple obesity has the advantages of small side effects, significant curative effect and high degree of patient acceptance.The theory of Piwei plays an important role in the treatment of simple obesity as an important practical theoretical basis in the clinical application of TCM.This paper analyzes the etiology and pathogenesis of simple obesity by combining the clinical experience of the treatment of simple obesity in recent years, and systematically discusses the application of Piwei theory in the clinical treatment of simple obesity, so as to provide some reference for the guidance of clinical practice. Reference | Related Articles | Metrics | Comments（0）

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Developments on radiogenomics based on MRI in lung cancer brain metastases SUI Lianyu, YIN Xiaoping, WANG Jianing Journal of Hebei Medical College for Continuing Education    2022, 39 (1): 25-34.   DOI: 10.3969/j.issn.1674-490X.2022.01.004 Abstract （312）      PDF（pc） （528KB）（190）       Knowledge map    Save Brain metastases are intracranial malignant tumors with high incidence and poor prognosis, brain metastases from lung cancer are the most common in clinical practice. MR is the preferred imaging diagnosis method for intracranial tumors, and MRI imagingomics is gradually applied to the precise and individualized diagnosis and treatment of brain metastases. With the continuous in-depth research on the connection between genes and tumors, tumor diagnosis is extended to the direction of molecular genetics. Radiogenomics is a method of fusing imaging phenotypes with genes and molecules, using non-invasive and accurate methods to detect tumors. The molecular genetic changes of the disease have been widely used in tumor discovery, treatment guidance and prognosis prediction, etc. This article reviews the feasibility and research progress of MRI radiogenomics radio genomics in brain metastases. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (5): 36-44.   DOI: 10.3969/j.issn.1674-490X.2021.05.006 Abstract （450）      PDF（pc） （466KB）（189）       Knowledge map    Save The malnutrition in patients with cancer has a high incidence, which is closely related to the poor treatment results and prognosis.So nutritional supplementation is significant extremely.Oral nutritional supplements are the first choice for nutritional supplements for cancer patients with basically normal gastrointestinal function.For cancer patients during treatment, oral nutritional supplements can help them maintain weight, improve body composition, improve nutritional status, reduce postoperative infection risks, enhance the tolerance of anti-cancer treatment reduce short-term readmission rates, and improve short-term survival.Moreover, the earlier the nutritional intervention, the more beneficial to the treatment and prognosis of patients.However, the effects of oral nutritional supplements in shortening the length of hospitalization, improving the quality of life and reducing mortality are controversia, and further in-depth research is still needed. This study mainly reviewed the effects of oral nutritional supplements used by cancer patients, and provided a basis for increasing the importance of oral nutritional supplements by hospitals, patients and their families. Reference | Related Articles | Metrics | Comments（0）

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Mediating effect of nurses' practicing environment on safety attitude and occupational well-being WANG Bei,MENG Jia,DU Xiaojing,WANG Weiming,QI Xinrong Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 60-66.   DOI: 10.3969/j.issn.1674-490X.2022.03.010 Abstract （262）      PDF（pc） （503KB）（188）       Knowledge map    Save Objective To explore the mediating effect of nurse practice environment on safety attitude and occupational well-being and give analysis of the role of working environment on safety attitude-occupational well-being. Methods From October to December,2021,cluster sampling was used to select 1 939 nurses from 5 tertiary hospitals in Baoding City as study subjects. The Nursing Work Index-Revised,the revised Chinese version of Safety Attitude Questionnaire(SAQ),and medical workers' occupational well-being scale were used to collect the data through “Question Star” on nurses' practicing environment and safety attitude and occupational well-being and analyze their correlation and mediating effect. Results 1939 nurses had a mean practicing environment score of 68.81±27.79,the mean SAQ score was 111.28±14.38, and the mean occupational well-being score of 62.43±28.17. Nurses' practicing environment and safety attitude,occupational well-being and safety attitude,occupational well-being and nurses' practicing environment were all significantly positively correlated(r=0.626,0.690,0.699,all P <0.05).Both of nurses' practicing environment and safety attitude could significantly predict occupational well-being. The mediating effect of nurses' practicing environment between occupational well-being and safety attitude was 0.268,which accounted for 42.405 percent of the total effect. Conclusion The nurses' practicing environment,safety attitude and occupational well-being of the third-grade hospitals in Baoding are not satisfactory. As part of the intermediary variables,the practice environment indirectly influences the relationship between safety attitudes and occupational well-being. Therefore, it is necessary to improve the nurse's working environment, strengthen the safety attitude, and promote the nurses' occupational happiness. Reference | Related Articles | Metrics | Comments（0）

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Advances on cancer-related fatigue and its influencing factors in patients with cervical cancer GUO Xinran, JING Kunjuan, ZHANG Lingling, WANG Bei Journal of Hebei Medical College for Continuing Education    2022, 39 (1): 75-80.   DOI: 10.3969/j.issn.1674-490X.2022.01.011 Abstract （259）      PDF（pc） （436KB）（187）       Knowledge map    Save This paper summarizes the current situation of cancer-related fatigue in patients with cervical cancer, and analyzes the impact of different factors on cancer-related fatigue, which is helpful to help nurses implement targeted and scientific nursing intervention, effectively alleviate cancer-related fatigue and improve the quality of life of patients. Reference | Related Articles | Metrics | Comments（0）

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Advances on vasculogenic mimicry in breast cancer WEI Yali,SUN Chengcheng,WANG Xiaochun Journal of Hebei Medical College for Continuing Education    2022, 39 (2): 16-23.   DOI: 10.3969/j.issn.1674-490X.2022.02.003 Abstract （257）      PDF（pc） （496KB）（185）       Knowledge map    Save Vasculogenic mimicry is a special model of angiogenesis. This structure is composed of tumor cells instead of traditional endothelial cells, and provides nutrition for tumor growth, invasion and metastasis. In recent years, it has been found that vasculogenic mimicry is related to the prognosis, invasion, metastasis and drug resistance of many kinds of malignant tumors. It is generally believed that vasculogenic mimicry and angiogenesis depend on some common mechanisms. And some people believe that the formation of vasculogenic mimicry is one of the reasons leading to the development of resistance to anti-angiogenic drugs. The mechanism of vasculogenic mimicry in breast cancer, including related signaling pathways, as well as tumor stem cells, epithelial mesenchymal and anti angiogenesis therapy, are reviewed. The significance and future direction of vasculogenic mimicry as a therapeutic target for breast cancer will be prospected. Reference | Related Articles | Metrics | Comments（0）

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Application of ultrasound monitoring of inferior vena cava diameter in critically ill patients HUANG Jiahui, FU Tingfei, LIANG Lu Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 41-46.   DOI: 10.3969/j.issn.1674-490X.2022.03.007 Abstract （229）      PDF（pc） （433KB）（181）       Knowledge map    Save Ultrasound monitoring of the inferior vena cava is a non-invasive, safe and repeatable technique, which can avoid adverse reactions such as infection due to invasive operations. Its diameter is correlated with central venous pressure, can reflect the patient's capacity status, assess the patient's condition development timely and accurately, and grasp the best treatment opportunity, which has guiding significance for the treatment of critically ill patients. Reference | Related Articles | Metrics | Comments（0）

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A bibliometric analysis of 10 years in the hot research and development trend of Yishui school based on CiteSpace XU Heng, ZHANG Jinmin, ZHANG Yaqi, LIU Dasheng, LI Fuhai, GE Shaoqin, ZHAO Hanqing Journal of Hebei Medical College for Continuing Education    2022, 39 (2): 29-40.   DOI: 10.3969/j.issn.1674-490X.2022.02.005 Abstract （289）      PDF（pc） （2036KB）（180）       Knowledge map    Save In order to analyze and discuss the research hotspots and development trends of the Yishui school in the field of domestic scholars in the past 10 years, the relevant literature of the Yishui school in CNKI, Wanfang, VIP in the recent 10 years were explored using bibliometrics. The CiteSpace software was applied to draw a knowledge map, and the amount of articles, research teams, issuing organizations, and keywords were visually analyzed and retrieved. The study included 2 397 related documents, 3 649 keywords, 17 keyword clusters; 53 authors published more than 5 articles, and found that Zhang Baochun and Ren Beida, Liu Guirong and Yao Wenxuan, Li Fuping and Dong Shangpu and other scholars were the three major academically influential teams represented mainly focus on Li Dongyuan and Piwei theory. In the past five years, they had begun to pay attention to other Yishui school representatives during the Ming and Qing Dynasties. In the past two years, we had produced certain results in the context of new coronavirus pneumonia, but the overall analysis of the internal organs identification theory and other researches were slightly insufficient, and the research methods were slightly outdated, suggesting that in the future we should strengthen the research on the traceability of the Yishui school and further improve the inheritance system of the Yishui school. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2021, 38 (6): 22-26.   DOI: 10.3969/j.issn.1674-490X.2021.06.004 Abstract （363）      PDF（pc） （426KB）（172）       Knowledge map    Save Objective To explore and compare the clinical efficacy of conventional chemotherapy combined with moxifloxacin or levofloxacin in the treatment of patients with multi-drug resistant pulmonary tuberculosis. Methods 98 patients with MDR-TB were selected from November 2019 to February 2021. According to the random digital table method, the patients in observation group were divided into two groups, 49 patients in observation group were treated with conventional chemotherapy and moxifloxacin, 49 cases in control group were treated with conventional chemotherapy and levofloxacin, and then compared after treatment. The clinical efficacy, immune function, focus absorption rate, sputum bacteria negative rate, cavity closure rate and adverse reactions were observed in the two groups. Results After treatment, the total effective rate of the observation group was 71.43%, which was significantly higher than that of the control group(P<0.05). After 18 months of treatment, the sputum negative conversion rate, lesion absorption rate and cavity closure rate of the observation group were 42.86%, 40.82% and 46.94%, respectively, which were significantly higher than those of the control group(P<0.05). After 18 months of treatment, the CD4+ in the observation group was(41.83±9.02)%, IgA was(4.08±0.62)g/L, IgG was(19.84±3.40)g/L,which were significantly higher than the control group. CD8+ was(29.83±5.62)%, which was significantly lower than that of the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups during the treatment(P>0.05). Conclusion The treatment of multi-drug resistant tuberculosis patients with conventional chemotherapy combined with moxifloxacin can significantly improve the immune function of patients, control the occurrence of adverse reactions, and the effects are accurate, which are worth popularizing and adopting in clinical practices. Reference | Related Articles | Metrics | Comments（0）