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    Advances on determination methods of flavonoids in Chinese herbal medicine
    YANG Hui,YANG Tianrun,MA Ziyun
    Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 9-13.   DOI: 10.3969/j.issn.1674-490X.2022.03.002
    Abstract683)      PDF(pc) (436KB)(501)       Save
    Flavonoids are a kind of natural organic compounds widely existing in plants and are abundant in many Chinese herbal medicines. As an effective component of many traditional Chinese medicines, flavonoids play an important role in the treatment of diseases due to their extensive physiological or pharmacological activities, and are widely used in clinical practice. Therefore, the determination of such compounds in Chinese herbal medicine is one of the important links in drug quality control. In this paper, different determination methods of flavonoids in Chinese herbal medicine are reviewed.
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    HAO's clinical experience of traditional Chinese medicine in Baoding in ophthalmology
    MENG Hongwei
    Journal of Hebei Medical College for Continuing Education    2022, 39 (4): 45-54.   DOI: 10.3969/j.issn.1674-490X.2022.04.007
    Abstract560)      PDF(pc) (515KB)(341)       Save
    HAO's ophthalmology of traditional Chinese Medicine(TCM)is the specialty of TCM in Baoding. HAO Dexin is a renowned Chinese ophthalmologist at the Hebei Institute of Traditional Chinese Medicine in Baoding in ancestral ophthalmology.HAO is a representative of traditional Chinese medicine ophthalmology.He has rich experience in diagnosis and treatment of diseases such as fulminant blindness, myopia and fundus oculi diseases.The curative effect is remarkable.HAO is good at treating eye diseases with traditional Chinese medicine and acupuncture.He has unique experience in the application of Chinese medicine prescription and the manipulation of acupoints.The diagnosis and treatment of ophthalmologic diseases should be based on the three Jing of Xin,Gan and Shen.
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    Journal of Hebei Medical College for Continuing Education    2023, 40 (2): 58-65.   DOI: 10.3969/j.issn.1674-490X.2023.02.009
    Abstract456)      PDF(pc) (478KB)(204)       Save
    As a chronic lifelong disease, the long-term disease management of diabetes predisposes patients to increase physical and psychological burdens, resulting in negative psychological distress, which affects patients' disease progression and quality of life. This article reviews the current status of psychological distress in diabetes, psychological distress assessment tools and influencing factors, and presents its own reflections to provide a reference for identifying, preventing and implementing targeted interventions for psychological distress in diabetes, and to point out the way for future related research.
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    Role of binocular vision function in the progression of myopia
    GAO Chunting, YUAN Hui, DU Junhui
    Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 14-20.   DOI: 10.3969/j.issn.1674-490X.2022.03.003
    Abstract392)      PDF(pc) (476KB)(348)       Save
    Myopia is a common disease in the population, and its incidence is increasing year by year, especially in children and adolescents, seriously affecting their physical and mental health. Binocular vision refers to that two eyes see at the same time, while external objects fall on the retina, forming retinal images, nerve excitatory transmission go to the brain higher center, so that the visual signals of two eyes merge into a single perceptual object. When viewing stereoscopic objects, due to the difference of normal pupil distance and the angle of faxation, the images formed on the retina of the two eyes are not completely symmetrical and have certain horizontal difference. This phenomenon is called Binocular Parallax, which gives us stereoscopic perception. Many studies have shown that binocular vision functions such as accommodation, convergence, stereoscopic vision and the development of myopia interact.The purpose of this article is to review the developments of binocular vision function and myopia in order to provide reference for the prevention and control of myopia to choose effective and appropriate programs.
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    Research status of fear disease progression in stroke patients
    HUANG Xianyi, LIU Shuang, LIU Yan, YUE Jie, CHEN Li
    Journal of Hebei Medical College for Continuing Education    2022, 39 (5): 68-74.   DOI: 10.3969/j.issn.1674-490X.2022.05.011
    Abstract327)      PDF(pc) (453KB)(139)       Save
    Stroke patients are prone to fear of disease or disease progression when faced with complex treatment periods, long recovery periods and unpredictable changes in the condition. Fear of disease progression will damage the physical and mental health, and social function of stroke patients, and eventually reduce the patient's rehabilitation and prognosis. This article reviews the concept, measurement tools, research status at home and abroad and influencing factors of fear disease progression, so as to provide reference for clinical nurses to deeply understand the present situation of fear disease progression of stroke patients and carry out relevant nursing practice and clinical management.
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    Journal of Hebei Medical College for Continuing Education    2022, 39 (6): 24-28.   DOI: 10.3969/j.issn.1674-490X.2022.06.004
    Abstract307)      PDF(pc) (458KB)(27)       Save
    Objective To compare the therapeutic effect of oral compound thrombolysis capsules combined with retinal photocoagulation, intravitreal injection ranibizumab and oral compound thrombolysis capsules combined with retinal photocoagulation in the treatment of retinal branch vein occlusion and macular edema. Methods A retrospective analysis was conducted in 42 patients with 42 eyes diagnosed with retinal branch vein occlusion and macular edema, and the patients were divided into two groups according to different treatment regimens: the experimental group(21 eyes)was treated with intravitreal injection ranibizumab combined with compound oral thrombolysis capsules and retinal photocoagulation, the control group(21 eyes)was given the compound thrombolysis capsule combined with retinal laser photocoagulation, the experimental group received ranibizumab intravitreal injection, while oral thrombolysis capsule, and retinal laser photocoagulation was performed 3 months later. The two groups underwent simple retinal photocoagulation and oral thrombosis capsules. The optimal corrected visual acuity of the two groups was examined during the 6-month treatment period, the changes of macular foveal retinal thickness were determined.Results After 6 months of treatment, the optimal corrected visual acuity of both groups was improved, and the treating effects of the experimental group was better than that of the control group, and the ophthalmic optical coherence tomography showed that the macular foveal thickness was reduced by 415.51 μm(61.45%)in the combination treatment group and 120.51 μm(27.40%)in the control group, which indicated that the treating effects of the experimental group was better than that of the controls. Conclusion Intravitreal injection of ranibizumab combined with oral compound thrombolysis capsule and retinal photocoagulation is safe and effective in the treatment of retinal branch vein occlusion and macular edema.
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    Development on digital orthopedic technology in clinical work
    YANG Xuping, LI Xingyong
    Journal of Hebei Medical College for Continuing Education    2022, 39 (4): 22-29.   DOI: 10.3969/j.issn.1674-490X.2022.04.004
    Abstract303)      PDF(pc) (516KB)(133)       Save
    Digital medicine is an emerging discipline that combines scientific informatics with medical technology, including 3D printing, finite element analysis and computer-aided orthopedic technology, and its application in the field of orthopedics is very extensive. Based on the many advantages of digital orthopedic technology in clinical work, it helps to solve the difficulties encountered in clinical work and has considerable application prospects, and its effective application in the clinic can benefit the majority of patients.
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    Journal of Hebei Medical College for Continuing Education    2023, 40 (1): 76-80.   DOI: 10.3969/j.issn.1674-490X.2023.01.012
    Abstract300)      PDF(pc) (393KB)(85)       Save
    The class of western medicine learning traditional Chinese medicine in Hebei Provincial School for Advanced Study of Traditional Chinese Medicineis was the earliest provincial-level educational institution of western medicine learning traditional Chinese medicine in Hebei province. In 1958, it was incorporated into Hebei College of Traditional Chinese Medicine and became the first batch students majoring in western medicine learning Chinese medicine Class(department)in Hebei College of Traditional Chinese Medicine. Through study of western medicine combined with learning traditional Chinese medicine education a large number of excellent talents for traditional Chinese medicine has been trained, which is one of the important forms of traditional Chinese medicine education. The class of western medicine learning traditional Chinese medicine in Hebei Provincial School for Advanced Study of Traditional Chinese Medicine was an active exploration of the standardized education of traditional Chinese medicine in western medicine learning traditional Chinese medicine, which has successfully trained some well-known persons, e.g. LIU Wenming, LI Huamin, SHU Jingzong etc. Collecting historical materials and the information of the class of western medicine learning traditional Chinese medicine in Hebei Provincial School for Advanced Study of Traditional Chinese Medicine, studying its teaching mode, can provide some successful experience for the development of traditional Chinese medicine education.
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    Advances on radiomics in adrenal adenoma
    WU Chunmei, YIN Xiaoping
    Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 29-34.   DOI: 10.3969/j.issn.1674-490X.2022.03.005
    Abstract284)      PDF(pc) (426KB)(305)       Save
    Adrenal adenoma is a common tumor in clinical practices. At present, initial progress has been made in the identification of adrenal benign and malignant tumors, functional adrenal adenoma subtypes, lipid adenoma and pheochromocytoma. Studies on adrenal adenoma are mainly carried out through texture analysis and histogram analysis, which can effectively evaluate tumor atypia and provide effective help in clinical decision-making.In addition, the normogram model combining clinical features and imaging features has a good identification effect for functional adrenal adenoma subtypes. The purpose of this article is to review the current status, problems and prospects of imaging in the diagnosis and differential diagnosis of adrenal adenoma, and the prediction, monitoring and prognosis of treatment strategies.
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    Developments on Kümmell's disease
    ZHANG Yin'en, JIAO Jianbao
    Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 47-53.   DOI: 10.3969/j.issn.1674-490X.2022.03.008
    Abstract277)      PDF(pc) (461KB)(143)       Save
    Kümmell's disease(KD)is a delayed form of vertebral ischemic necrosis after minor trauma. KD shows delayed vertebral compression fracture, and the most common lesion is at the junction of thoracolumbar spine. Patients with KD often have a history of minor trauma. Although the postoperative pain disappears, the symptoms often relapse and worsen, and kyphosis deformity occurs many years later.The diagnosis of KD depends not only on imaging technology, but also on the comprehensive analysis of patients' medical history and clinical symptoms. Intraspinal fracture caused by trauma is considered to be the most important feature in the diagnosis of KD. Patients with KD can adopt different treatment schemes according to whether there is nerve defect. Patients with KD without nerve defect can be treated with conservative treatment, percutaneous vertebroplasty(PVP), percutaneous kyphoplasty(PKP)and other methods.However, the above methods are often accompanied by leakage of bone cement.With the development of modern medicine and technology, in order to reduce the leakage of bone cement, clinicians have made a series of improvements to the operation on the basis of PVP, PKP, anterior reconstruction and posterior osteotomy, which effectively reduces the occurrence of complications and improves the quality of life of patients.
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    YIN Sizhen's experience in gynecology
    MENG Hongwei
    Journal of Hebei Medical College for Continuing Education    2022, 39 (5): 39-48.   DOI: 10.3969/j.issn.1674-490X.2022.05.007
    Abstract267)      PDF(pc) (537KB)(117)       Save
    This paper introduces YIN Sizhen's experience in diagnosis and treatment of gynecological diseases.YIN Sizhen was a famous gynecologist in Dingzhou of Baoding in the 1950s, ancestral Chinese medicine gynecology in three generations, practicing medicine for decades, with a wealth of clinical experience. This article is based on the oral contents of YIN Sizhen compiled by GUO Zhongyuan and ZHANG Fengchi of Hebei Academy of Traditional Chinese Medicine in 1960 to introduce his experience in gynecology. YIN Sizhen made an in-depth study of FU Qingzhu Nüke, payed attention to pulse-taking, realized that the focus of the book for the ups and downs of Yin and Yang. It is believed that most gynecological Re Zheng are based on deficiency of Yin and body fluid, rarely using antipyretic drugs with bitter cold; most of the gynecological Han Zheng are due to the insufficiency of Huo of Mingmen and Xinbao Luo and good at using of Yang warming drugs; good at Liqi and Huoxue drugs to regulate menstruation, as Yin and Yang, Qi and Xue are at peace, all syndromes can be cured.
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    Journal of Hebei Medical College for Continuing Education    2023, 40 (4): 1-10.   DOI: 10.3969/j.issn.1674-490X.2023.04.001
    Abstract266)      PDF(pc) (830KB)(223)       Save
    As a hormone secreted by white fat cells, leptin acts as a peripheral signal linking adipose tissue and the central nervous system networks, affecting feeding, energy balance, endocrine and immune functions. Through the analysis and summary of molecular structure and intracellular distribution of leptin and its receptor(LEPR), the recent developments on the regulation of lipid metabolism, inflammation and immunity, wound healing and tumor development are reviewed.
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    Mediating effect of nurses' practicing environment on safety attitude and occupational well-being
    WANG Bei,MENG Jia,DU Xiaojing,WANG Weiming,QI Xinrong
    Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 60-66.   DOI: 10.3969/j.issn.1674-490X.2022.03.010
    Abstract262)      PDF(pc) (503KB)(188)       Save
    Objective To explore the mediating effect of nurse practice environment on safety attitude and occupational well-being and give analysis of the role of working environment on safety attitude-occupational well-being. Methods From October to December,2021,cluster sampling was used to select 1 939 nurses from 5 tertiary hospitals in Baoding City as study subjects. The Nursing Work Index-Revised,the revised Chinese version of Safety Attitude Questionnaire(SAQ),and medical workers' occupational well-being scale were used to collect the data through “Question Star” on nurses' practicing environment and safety attitude and occupational well-being and analyze their correlation and mediating effect. Results 1939 nurses had a mean practicing environment score of 68.81±27.79,the mean SAQ score was 111.28±14.38, and the mean occupational well-being score of 62.43±28.17. Nurses' practicing environment and safety attitude,occupational well-being and safety attitude,occupational well-being and nurses' practicing environment were all significantly positively correlated(r=0.626,0.690,0.699,all P <0.05).Both of nurses' practicing environment and safety attitude could significantly predict occupational well-being. The mediating effect of nurses' practicing environment between occupational well-being and safety attitude was 0.268,which accounted for 42.405 percent of the total effect. Conclusion The nurses' practicing environment,safety attitude and occupational well-being of the third-grade hospitals in Baoding are not satisfactory. As part of the intermediary variables,the practice environment indirectly influences the relationship between safety attitudes and occupational well-being. Therefore, it is necessary to improve the nurse's working environment, strengthen the safety attitude, and promote the nurses' occupational happiness.
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    Journal of Hebei Medical College for Continuing Education    2022, 39 (6): 53-57.   DOI: 10.3969/j.issn.1674-490X.2022.06.009
    Abstract258)      PDF(pc) (411KB)(68)       Save
    Liu Wansu is a representative of the Hejian School, and his academic system is dominated by the theories of “restraining excessiveness to acquire harmony” and “fire-heat theory.” The concept of “restraining excessiveness to acquire harmony” first appeared in Suwen(Plain Questions), and its specific connotation has been continuously expanded by subsequent generations. For example, Liu Wansu used various phenological phenomena in nature as the foundation for further linking the pathophysiological phenomena of the body. At the same time, Liu Wansu highly values his theory of disease caused by fire-heat pathogens. He re-exposed the theory of disease caused by “six Qi” based on “pathogenesis item 19.”He not only greatly expanded the types of fiery diseases, but also creatively proposed the conclusion that “six exogenous pathogenic factors transfer from fire”. Through researching a large amount of data, we believes that the “stagnation syndrome theory” is the internal bridge linking the “restraining excessiveness to acquire harmony” theory and the “fire-heat theory” theory. Based on the idea, subsequent generations of doctors consistently supplement the depression syndrome theory. As a result, the following discussion is based on this, and we believe that combining related theories will be more conducive to Liu Wansu's academic thoughts research, and better apply them to clinical practice.
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    Journal of Hebei Medical College for Continuing Education    2023, 40 (1): 10-21.   DOI: 10.3969/j.issn.1674-490X.2023.01.002
    Abstract252)      PDF(pc) (703KB)(151)       Save
    Retinitis pigmentosa(RP)is an inherited disease of progressive damage to visual cells with genotypic and phenotypic heterogeneity. Up to now, 103 RP pathogenic genes have been identified, among which there is a type of genes(PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, RP9, and DHX38)that is related to pre-mRNA splicing. This type of genes is widely expressed throughout the body, but its mutation, the mechanism behind the disease that causes this tissue-specific phenotype of RP is currently unclear. This paper summarized the research progress in recent years,introduced the splicing process of pre-mRNA, the role of pre-mRNA splicing factors in the splicing process, and the disease model of RP caused by pre-mRNA splicing factors, and discussed the mutations of pre-mRNA splicing factors contribute to the pathogenic mechanism of RP.
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    Developments on telemedicine in management of senile hypertension
    HUANG Shengnan,ZHAO Rui,XIAO Nuan
    Journal of Hebei Medical College for Continuing Education    2022, 39 (4): 39-44.   DOI: 10.3969/j.issn.1674-490X.2022.04.006
    Abstract248)      PDF(pc) (459KB)(168)       Save
    Essential hypertension is one of the most common chronic diseases in the elderly, and it is also the most common risk factor of acute cardiovascular and cerebrovascular diseases.As a new hypertension management model, telemedicine plays an important role in medication compliance and hypertension control rate of patients with hypertension.This paper summarizes telemedicine and its concept in the management of senile hypertension, the application status of telemedicine in the management of senile hypertension and the suggestions to speed up the development of telemedicine management model.
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    Advances on chronic obstructive pulmonary disease associated pulmonary hypertension
    WANG Jing, HAN Li, ZHANG Zeming
    Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 21-28.   DOI: 10.3969/j.issn.1674-490X.2022.03.004
    Abstract247)      PDF(pc) (486KB)(160)       Save
    Chronic obstructive pulmonary disease(COPD)has become a global public health problem due to its large number of patients, high mortality rate and heavy social and economic burden. Pulmonary hypertension, pulmonary heart disease and heart failure caused by COPD seriously threaten life health and quality of life of patients. The quality of life can be improved if the disease can be controlled in time, effectively controlled and slowed down. This article reviews the pathogenesis, clinical manifestations, diagnosis and treatment of COPD associated pulmonary hypertension.
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    Research status of sexual health of graduate students in China
    LUO Xiaofeng, ZHANG Liyuan, WAN Yijing, ZHENG Qingyong, ZHU Qingshuang, HUANG Yichen
    Journal of Hebei Medical College for Continuing Education    2022, 39 (5): 49-52.   DOI: 10.3969/j.issn.1674-490X.2022.05.008
    Abstract247)      PDF(pc) (465KB)(101)       Save
    Graduate students are an important talent reserve team in China. Their bodies and minds are relatively mature and they are in a period of active sexual activity, and they receive more free and flexible education. It is very necessary to understand the current situation of sexual health of graduate students. In this paper, 96 relevant literatures were collected from CNKI, Wanfang Data and VIP for visual analysis and content review. The research on sexual health of graduate students was not comprehensive, the students only knew the general knowledge of sex, and high-risk sexual behavior occured from time to time. The majority of scholars should pay more attention to the sexual health of postgraduates in their research work, and educational institutions such as colleges and universities should also pay attention to postgraduates' sex education.
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    Prospect of treatment of retinal vein edema combined with macular edema
    HAO Jianzhang, ZHANG Hu
    Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 35-40.   DOI: 10.3969/j.issn.1674-490X.2022.03.006
    Abstract245)      PDF(pc) (453KB)(201)       Save
    Retinal vein occlusion(RVO)is the most common retinal vascular disease and one of the most common causes of blindness. The incidence of RVO increases with age. Most patients are over 65 years old, but the age of onset of the disease is also getting younger because of changes in the Chinese diet. Macular edema, often accompanied by retinal vein occlusion, is also a major cause of vision loss in patients with the disease.At present, there are many treating approaches for the patients with retinal vein occlusion combined with macular edema. Each method has its different effects due to the individual differences of the patients. To date, different treatment schemes are conducted according to the patients' own conditions, and most of them are combined with several treatment methods. By consulting relevant literatures and personal experience in the process of treating patients, the author summarizes and discusses the prospects of the treatment methods, curative effects, prognosis and costs of retinal vein occlusion complicated with macular edema, so as to find potential problems and influencing factors and explore the best clinical treatment regimen.
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    Construction of curriculum system of rehabilitation treatment technology specialty based on post standard
    LI Ruiming, DUAN Kaixuan, CUI Dandan, GUO Yu
    Journal of Hebei Medical College for Continuing Education    2022, 39 (4): 73-80.   DOI: 10.3969/j.issn.1674-490X.2022.04.011
    Abstract240)      PDF(pc) (441KB)(164)       Save
    The curriculum system is the basic guarantee for the quality of talent training. The post standard has the dual effect of testing the quality of talent training and talent employment screening.At present, the curriculum system of rehabilitation technology specialty in China is not consistent enough, which restricts the realization of talent training objectives and specifications, and affects the efficient implementation of healthy China strategy.The basic premise of ensuring the quality of talent training is to reconstruct the curriculum system of rehabilitation technology specialty, reorganize the teaching content and compile integrated teaching materials according to the post standards of rehabilitation treatment.
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    Simple obesity and application of TCM Piwei theory
    ZHANG Jinghui,ZHAO Hanqing,WANG Zewen,XIANG Hongwei,GE Shaoqin
    Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 54-59.   DOI: 10.3969/j.issn.1674-490X.2022.03.009
    Abstract235)      PDF(pc) (453KB)(191)       Save
    Simple obesity refers to obesity without obvious disease inducement, which is caused by genetic factors and environmental factors.Clinical practice shows that the TCM treatment of simple obesity has the advantages of small side effects, significant curative effect and high degree of patient acceptance.The theory of Piwei plays an important role in the treatment of simple obesity as an important practical theoretical basis in the clinical application of TCM.This paper analyzes the etiology and pathogenesis of simple obesity by combining the clinical experience of the treatment of simple obesity in recent years, and systematically discusses the application of Piwei theory in the clinical treatment of simple obesity, so as to provide some reference for the guidance of clinical practice.
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    Application of ultrasound monitoring of inferior vena cava diameter in critically ill patients
    HUANG Jiahui, FU Tingfei, LIANG Lu
    Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 41-46.   DOI: 10.3969/j.issn.1674-490X.2022.03.007
    Abstract229)      PDF(pc) (433KB)(181)       Save
    Ultrasound monitoring of the inferior vena cava is a non-invasive, safe and repeatable technique, which can avoid adverse reactions such as infection due to invasive operations. Its diameter is correlated with central venous pressure, can reflect the patient's capacity status, assess the patient's condition development timely and accurately, and grasp the best treatment opportunity, which has guiding significance for the treatment of critically ill patients.
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    Journal of Hebei Medical College for Continuing Education    2023, 40 (1): 46-51.   DOI: 10.3969/j.issn.1674-490X.2023.01.007
    Abstract228)      PDF(pc) (428KB)(98)       Save
    Objective To explore the changes in the physical health of college students from 2019 to 2020 and make suggestions on the healthy lifestyle of college students. Methods Through researching literature, testing, and mathematical statistics, comparing the physical fitness test results of college students, freshmen to seniors of Hebei University in 2019 and 2020 were surveyed and tested according to the method of Physical Fitness and Health Surveillance of Chinese Students. Results 25 603 participants were tested in 2019, including 10 192 boys and 15 411 girls. In 2020, 32 757 students participated in the test, including 13 308 boys and 19 449 girls. T test results showed that under the epidemic, the BMI index and flexibility of boy students increased(P<0.01); the physical function and strength of boys decreased(P<0.01); the flexibility of girls, upper limb strength increased(P<0.05), speed quality, endurance quality, lower limb strength decreased, and the differences were statistically significant(P<0.01). Conclusion From 2019 to 2020, the body shape, physical function, and physical fitness of college students have declined significantly. The physical health of college students changed in 2020. Educational institutions should design post-epidemic sports programs in response to the decline in the physical health of college students to improve their physical health.
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    Advances on pathophysiological mechanism of postoperative delirium in elderly patients
    GAO Qi,SUN Tianpei,WU Guangyi
    Journal of Hebei Medical College for Continuing Education    2022, 39 (4): 8-13.   DOI: 10.3969/j.issn.1674-490X.2022.04.002
    Abstract225)      PDF(pc) (442KB)(114)       Save
    Postoperative delirium(POD)is characterized by decreased attention,consciousness and cognitive disorders and perceptual disorders.It tends to occur in elderly patients,and is closely related to prolonged hospital stay,increased economic burden,reduced quality of life and increased postoperative mortality.At present,the pathophysiology and pathogenesis of POD have not been fully defined,and there are no effective biological and clinical indicators,which affects the early diagnosis and prevention of POD to a certain extent.This paper reviews the pathogenesis of POD in recent years in order to have a clearer understanding of POD from the physiological mechanism and provide more effective methods for the prevention and treatment of POD in clinic.
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    Effect of RG108 on proliferation and gene expression of HT22 cell line
    JIANG Le,WANG Xiaobing,HE Ershu,ZHENG Xiaoye,GONG Zhiting
    Journal of Hebei Medical College for Continuing Education    2022, 39 (4): 1-7.   DOI: 10.3969/j.issn.1674-490X.2022.04.001
    Abstract221)      PDF(pc) (809KB)(219)       Save
    Objective To investigate the effect of DNA methyltransferase inhibitor RG108,on HT22 cells,a mouse hippocampal neuronal cell line cultured in vitro.Methods HT22 hippocampal neuronal cells cultured in vitro were treated with DNA methyltransferase inhibitor RG108 at concentrations of 0.5,5,and 50 μmol/L,and the cell viability was detected with CCK-8,and the expression of middle and downstream genes in the cells was detected using RT-qPCR.Results CCK-8 assay showed that 50 μmol/L RG108 could promote the proliferation of HT22 cells after 48 and 72 hours and the difference was statistically significant(P<0.05).RT-qPCR results demonstrated that the expression of synaptic plasticity-related genes nr1 and reln decreased in HT22 cells treated with 50 μmol/L RG108,and the difference was statistically significant(P<0.05).Conclusion DNA methyl transferase inhibitor RG108 can promote the proliferation of mouse hippocampal cell line HT22 cells and regulate the expression of neuroplasticity-related genes.Moreover,RG108 may affect synaptic plasticity,which may influence synaptic plasticity-related behaviors such as memory formation.
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    Advances on artificial intelligence in the diagnosis and treatment of urinary calculi
    ZHAN Xiaofei, CUI Zhenyu, ZHAO Chunli
    Journal of Hebei Medical College for Continuing Education    2022, 39 (4): 30-38.   DOI: 10.3969/j.issn.1674-490X.2022.04.005
    Abstract220)      PDF(pc) (523KB)(161)       Save
    As healthcare systems continue to digitize and medical data continue to increase, clinicians face significant challenges in making accurate diagnoses, developing personalized treatment plans, and determining prognoses. There are some problems such as unknown formation factors, complex components, and large anatomical differences in the occurrence sites of urinary calculi, which hinder the personalized diagnosis and treatment of patients with calculi. Artificial intelligence can flexibly analyze and learn different data types, providing new ideas for the accurate diagnosis and treatment of urinary calculi. This paper reviews the research content of artificial intelligence in the diagnosis and treatment of urinary calculi to improve the understanding of the application of artificial intelligence in the diagnosis and treatment of urinary calculi.
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    The influence of learning style characteristics on the effect of laparoscopic camera navigation training
    ZHAI Bo, ZHU Qiankun, LI Xiaodong, HU Fengli, JIN Xin
    Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 74-80.   DOI: 10.3969/j.issn.1674-490X.2022.03.012
    Abstract213)      PDF(pc) (620KB)(103)       Save
    Objective To analyze the learning styles of medical students and explore the influence of different learning styles on the training of laparoscopic camera navigation training. Methods Before the laparoscopic camera navigation training of camera assistants, 60 interns and 40 postgraduates were assessed with Kolb learning style scale; then the differences of learning style characteristics between interns and postgraduates were analyzed and compared, as well as the influence of different learning style characteristics on the laparoscopic camera navigation training. Results There were significant differences in learning styles characteristics between interns and postgraduates(P<0.001). In the Intern Group, the diverging learning style is the main one, while in the postgraduate group, the converging learning style is the main one(P<0.001). Learning style characteristics have a significant impact on the effect of laparoscopic camera navigation training. The average number of errors in each cycle of centering, neutral horizon and optimum distance of interns and postgraduates with the converging learning style were significantly less than those with diverging, assimilating and accommodating learning styles(P<0.001). Conclusion There are significant differences among medical students in learning style characteristics. Learning style characteristics have a significant impact on the training effects in laparoscopic camera navigation training. In medical education, we should give full consideration to the differences in learning style characteristics, and give full play to the advantages of students' learning styles.
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    Advances on the enrichment of heavy metals in traditional Chinese medicine
    MA Xiaoli, WANG Hu, LIANG Cuiyun, ZHANG Yi
    Journal of Hebei Medical College for Continuing Education    2022, 39 (5): 31-38.   DOI: 10.3969/j.issn.1674-490X.2022.05.006
    Abstract212)      PDF(pc) (511KB)(143)       Save
    As a special drug for disease prevention and treatment, traditional Chinese medicine has been paid more and more attention by people all over the world. However, the absorption and accumulation of heavy metals in medicinal plants pose a potential threat to human health. In this paper, the contents of heavy metals in traditional Chinese medicine and the rules of absorption and accumulation are summarized in order to provide references for the research and safe production of heavy metals in traditional Chinese medicine.
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    Exploration on the application of modular teaching method in medical imaging specialty curriculum
    LIU Ning, LÜ Xiaohong, SUN Yu, ZHANG Xianglin
    Journal of Hebei Medical College for Continuing Education    2022, 39 (5): 75-80.   DOI: 10.3969/j.issn.1674-490X.2022.05.012
    Abstract197)      PDF(pc) (462KB)(153)       Save
    Objective To explore and clarify the necessity and practicability of modular teaching reform in medical imaging technology and medical imaging equipment. Methods The students of medical imaging major of grade 2019 were divided into the experimental group and the control group, the teaching contents of medical imaging examination technology course and medical imaging equipment course were divided into modules. The experimental group used modular teaching method to teach, while the control group used traditional teaching mode to teach.The final examination scores of the two groups of students and their satisfaction with the teaching effect were analyzed. Results The results of final examination and teaching effect satisfaction survey of the experimental group were higher than those of the control group(P<0.05). Conclusion The courses of the medical imaging technology and medical imaging equipment, the implementation of the modular helps to build students' knowledge system, cultivate the students' subjective initiative, the training goal of medical image practical talents, further medical imaging technology and equipment, the practical problems in teaching.
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    Reproductive concern status and its influencing factors in gynecological cancer patients
    XU Li,LIU Wenjuan,ZHANG Li
    Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 67-73.   DOI: 10.3969/j.issn.1674-490X.2022.03.011
    Abstract194)      PDF(pc) (482KB)(200)       Save
    Objective To understand the level of reproductive concern in gynecological cancer patients, and explore its status and influencing factors. Methods Reproductive Concerns after Cancer Scale(RCACs)and Self-perceived Burden Scale for Cancer Patients(SPBS-CP)were collected from 134 gynecologic cancer patients. Results Average RCAC score in gynecological cancer patients was 48.88±13.59.SPBS-CP score was 50.92±17.38.There were differences in reproductive concern levels among patients in different groups(age, willingness to bear children, number of children, content of communication, and self-perceived burden level)(P<0.01).Self-perceived burden and all dimensions were positively correlated with reproductive concern(P< 0.01). After multiple linear regression analysis:Fertility willingness and self-perceived burden were important independent influencing factors of reproductive concern in gynecological cancer patients(P< 0.01).Conclusion Gynecological cancer patients reproductive concern is above medium level. Attention should be paid to those with reproductive needs and heavy self-perceived burden. Taking effective measures to reduce the self-perceived burden of patients through the joint efforts of the government, the hospital and the family can alleviate their reproductive concern.
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    Effect of enhanced sensory stimulation-oriented facilitation technique in the rehabilitation of upper limb function after stroke
    XIE Ruijuan, DENG Yun, LIU Juan, YANG Nan,ZHANG Kun
    Journal of Hebei Medical College for Continuing Education    2022, 39 (4): 14-21.   DOI: 10.3969/j.issn.1674-490X.2022.04.003
    Abstract192)      PDF(pc) (508KB)(129)       Save
    Objective To explore the influence of strengthening facilitation technique guided by sensory stimulation on the rehabilitation effect of upper limb function in stroke patients on occupational therapy. Methods Sixty patients with paraplegia and spasms during stroke that were treated in our department from June 2018 to May 2020 were selected as the subjects of the study. These patients were divided into therapy group(n=30)and control group(n=30). Both groups received routine rehabilitation on this basis. The therapy group were given strenghening facilitation techniques such as Brunnstrom technique, Bobath technique, Rood technique, PNF(propriceptive neuromuscular facilitation)technique, especially strengthening the application of the sense of stimulation ingredients to stimulate multi-sensory paths such as visual hearing, shallow sensations, ontogenal sensations, composite sensations and by password, brushing, tapping, pressing, extrusion, stretching, cold water, warm water, resistance, control and other measures, the treatment period was 12 weeks. Fugl-Meyer Assessmont Scnle(FMA)-upper limb was used to examine the rate the motor function of 2 groups of patients before and 6 weeks and 12 weeks after treatment. Ability of ADL(activities of daily living)was scored in 2 groups of patients before and 6 weeks and 12 weeks after treatment using an improved Barthel index scale(modified Barthel index, MBI). In strumental ADL ability 2 groups half a year after discharge using Functional Activity Questionnaires(FAQ), the Brunnstrom stage was used to determine the rate the proportion of partial separation exercise period and separation exercise period at 12 weeks of treatment in 2 groups. Results 2 groups after 6 weeks and 12 weeks had significant effects compared to pre-treatment,and the exercise ability and ADL ability of the therapy group were better than that of the control group, the exercise ability and ADL ability of the two groups after 12 weeks were better than those of the group after 6 weeks(all P<0.01). In strumental ADL ability of the therapy group was better than that of the control group(P<0.01). In 2 groups half a year after discharge, there were significantly more cases of patients with upper limb movement function recovery up to Brunnstrom 4 and above treatment group than in 2 groups(all P<0.01), it was shown that strengthening sensory stimulation in rehabilitation training could enable the patients to obtain better rehabilitation results. Conclusion The use of facilitation technique in occupational therapy, especially the strengthening of the sensational stimulation component of facilitation technique, can significantly promote the process of motor function rehabilitation in patients with paraplegia with stroke paraplegia, significantly improve the movement function of the upper limbs of patients, and improve ADL ability.
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    Journal of Hebei Medical College for Continuing Education    2023, 40 (2): 52-57.   DOI: 10.3969/j.issn.1674-490X.2023.02.008
    Abstract187)      PDF(pc) (464KB)(110)       Save
    CUI Mingyuan was a famous Chinese medicine practitioner in Baoding in the 1950s, whose survival data in treating diseases were extremely rare. The contents of the newly discovered notes in CUI Mingyuan's medical records were compiled in order to introduce his clinical experience in diagnosis and treatment of exogenous diseases. CUI Mingyuan had made an in depth study of Yishui school academic thinking in traditional Chinese medicine, who was good at applying the experience of Yishui school in the diagnosis and treatment of exogenous diseases. He paid attention to the theory of medicine channel-tropism, used Sanfeng drugs to drive out the pathogenic factors, adjusted the body Qi and mechanism, and paid attention to clinical practice to get mutual regulation by using both Han and Wen. At the same time, he paid attention to protecting the Pi and Wei, attaching importance to Yangqi, and he had unique experience in the diagnosis and treatment of exogenous diseases.
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    Qualitative research on learning experience of medical students' professional accomplishment education based on palliative medicine
    CUI Meng,LI Na,WANG Yumei
    Journal of Hebei Medical College for Continuing Education    2022, 39 (4): 55-60.   DOI: 10.3969/j.issn.1674-490X.2022.04.008
    Abstract185)      PDF(pc) (483KB)(99)       Save
    Objective To explore the learning experience of medical students on the teaching mode of professional accomplishment education based on palliative medicine.Methods The semi-structured interview method was adopted to interview 12 medical undergraduates who participated in this course.The data were analyzed with Colaizzi 7-step analysis method.Results Five themes were extracted from the learning experience of medical students,namely,enhanced altruism;enhanced professional values;increasing knowledge and learning ability;improving recognition of the concept of death and developing empathy ability.Conclusion The professional accomplishment education based on palliative medicine is beneficial to improve medical students' professional values,enhance their learning ability and initiative,then improve their professional accomplishment.
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    Application of scene introduction combined with case-based learning model in anesthesiology teaching
    WEI Fusheng, YE Lingling, HUANG Yuanlu, MA Longxian, YANG Lei
    Journal of Hebei Medical College for Continuing Education    2022, 39 (4): 61-65.   DOI: 10.3969/j.issn.1674-490X.2022.04.009
    Abstract185)      PDF(pc) (428KB)(89)       Save
    Objective To explore the effect of scene introduction strategy combined with case-based leaning(CBL)in anesthesiology teaching.Methods The undergraduate students majoring in anesthesiology in Nanchang University were randomly divided into control group and observation group according to the random number table method.The control group(26 students)was taught by the CBL,and the observation group(27 students)was taught by the scene introduction strategy combined with the CBL.And the class room test was conducted after each class.At the end of the semester,the scores of the two groups in theoretical test,experimental test and classroom test were compared,and a questionnaire survey was conducted according to the students' satisfaction with the teaching effect.Results The scores of the observation group in classroom test,theoretical test and experimental test were significantly higher than those of the control group,the difference was statistically significant(P<0.05).The questionnaire survey showed that the satisfaction rate of the observation group was significantly higher than that of the control group in improving academic performance,stimulating learning interest,promoting active learning,improving learning efficiency and students' satisfaction with teaching methods,with statistical significance(P<0.05).The questionnaire survey showed that the satisfaction rate of students in the observation group was significantly higher than that in the control group(P<0.05).Conclusion The application of the scene introduction strategy combined with the CBL in clinical anesthesiology teaching can significantly improve the theoretical level and clinical practice ability of anesthesia students.The application of this mode in anesthesiology teaching has achieved good teaching results,which is worthy of popularization and application in teaching.
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    The effect of interferon-α2b on PD-1/PD-L1 signaling pathway of HEL cells
    QI Lin,CHENG Zhiyong,ZHANG Lijun,WANG Meng,WANG Baoyan
    Journal of Hebei Medical College for Continuing Education    2022, 39 (3): 1-8.   DOI: 10.3969/j.issn.1674-490X.2022.03.001
    Abstract178)      PDF(pc) (848KB)(125)       Save
    Objective To study the effects of interferon-α2b(IFN-α2b)on proliferation and apoptosis and the influence with programmed death-1(PD-1)and programmed death ligand-1(PD-L1)of JAK2 V617F positive human erythroleukemia HEL cells. Methods Different concentrations of IFN-α2b were applied to human erythroleukemia HEL cell lines. CCK-8 was used to detect cell viability and caspase-3/7 activity was detected by caspase-3/7 activity assay kit. The expression levels of JAK2, PD-1 and PD-L1 mRNA were detected by fluorescence quantitative PCR. Flow cytometry was used to detect the effects of different concentrations of interferon-α2b on the expression of PD-1 and PD-L1 protein in HEL. Results Different concentrations of IFN-α2b could inhibit HEL cell proliferation in time and dose-dependent manner. IFN-α2b could increase caspase-3/7 activity of HEL cells in a dose and time-dependent manner; IFN-α2b could reduce JAK2 V617F mutation in a dose-dependent manner,inhibit the expression of PD-1 mRNA and protein, and slightly increase the expression of PD-L1.Conclusion IFN -α2b may inhibit HEL proliferation and participate in the regulation of PD-1/PD-L1 expression.
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    Journal of Hebei Medical College for Continuing Education    2022, 39 (6): 1-8.   DOI: 10.3969/j.issn.1674-490X.2022.06.001
    Abstract176)      PDF(pc) (591KB)(38)       Save
    Objective To explore the classic prescriptions of Tibetan medicine for the treatment of Langxiu disease(eczema), and sort out and improve the classic theory of the famous prescription Wuwei Jianghuang ointment which is widely used and has good curative effects, and examines its effects on the eczema mouse model, and analyzes and evaluates its effects on the eczema mouse model, then acute toxic effects on the skin. Methods Fifty BALB/c mice,10 mice were randomly selected as blank group, and the other 40 mice were prepared to model eczema. The mice were sensitized twice with 7% high concentration DNCB acetone olive oil solution, and then stimulated once with 0.5% low concentration DNCB acetone olive oil solution 20 μL. Acute dermatitis such as erythema, edema and exudation of back skin were observed. After successful modeling, 40 eczema mice were randomly divided into 4 groups, which were model group,the hydrocortisone butyrate cream group Wuwei Jianghuang ointment high-dose group and Wuwei Jianghuang ointment low-dose group, with 10 mice in each group. Except the model group, the other 3 groups were treated with corresponding drugs for 36 days, respectively, to determine the drug efficacy. Another 16 New Zealand rabbits were selected and divided into 4 groups by random number table method. Continuous observation went on for 14d, 2 times a day. Results Blind scoring of the back skin of mice in each group found that the high and low dose groups of Wuwei Jianghuang ointment had a good healing effect on the back skin lesions of mice. Compared with the model group, the high-dose and low-dose Wuwei Jianghuang ointment groups and the hydrocortisone butyrate cream group had statistical significance in the skin lesion scores on the 15th and 30th days(P<0.01), and had statistical significance in the ear swelling thickness(P<0.01). And had statistical significance in the spleen index of mice(P<0.01). Compared with the model group, the high and lowdose groups of Wuwei Jianghuang ointment and hydrocortisone butyrate cream groups had statistical significance in reducing the serum TNF-α level of mice(P<0.01). There were no statistical significance in decreasing serum IL-6 in mice between the high and low dose groups of Wuwei Jianghuang ointmenthad(P>0.05). Wuwei Jianghuang ointment had no obvious toxicity. Conclusion After the positive control study of Wuwei Jianghuang ointment and hydrocortisone butyrate ointment, the curative effects of Wuwei Jianghuang ointment in the treatment of Langxiu disease(eczema)is confirmed to be second only to hydrocortisone butyrate ointment, and the efficacy of Wuwei Jianghuang ointment in ancient Tibetan medicine books on the treatment of Langxiu disease(eczema)is confirmed too. Wuwei Jianghuang ointment can be used in normal dosage for normal skin and damaged skin.
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    Development of a training needs assessment tool for advance care planning for health care professionals
    DONG Tiaoxia, HE Chunju, TAN Jin, YANG Shan, DENG Renli
    Journal of Hebei Medical College for Continuing Education    2022, 39 (5): 53-61.   DOI: 10.3969/j.issn.1674-490X.2022.05.009
    Abstract167)      PDF(pc) (545KB)(70)       Save
    Objective To provide the research basis for the next step of training needs investigation. Methods The item pool of advance care planning training needs assessment tool was initially constructed by literature analysis and data review. Then the English items were translated and adjusted according to the Brislin translation model, and the items were revised by Delphi expert consultation and pre-survey. Results After literature analysis and data review, 23 items were identified, involving three themes: basic knowledge, specialized knowledge and communication skills. After translation and back translation, the overall semantic evaluation of the scale was high, the semantic equivalence of the items was 78.6% to 100.0%, and the semantic equivalence of the scale was 82.6% to 100.0%. After two rounds of consultation, the enthusiasm of experts was 100%, the degree of expert authority was 0.87, the coordination coefficient of expert consultation was 0.271 and 0.353, the mean importance of each item ranged from 4.29 to 5.00, and the coefficient of variation ranged from 0.05 to 0.11. Among the 40 medical staff who evaluated the face validity of the scale, the recognition of each item of the scale was 87.5% to 100.0%. Conclusion The developed training needs assessment tool of advance care planning for medical workers is reasonable as a whole. The Chinese-translated items can provide a research basis for the next step of training needs investigation.
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    The role of microRNA in high phosphorus induced vascular calcification
    JIA Juan, LIANG Si, CHEN Hengli, WANG Hongjie
    Journal of Hebei Medical College for Continuing Education    2022, 39 (5): 1-6.   DOI: 10.3969/j.issn.1674-490X.2022.05.001
    Abstract166)      PDF(pc) (370KB)(80)       Save
    Vascular calcification is the pathological basis of the occurrence and development of cardiovascular disease in patients with chronic kidney disease. Hyperphosphatemia is the most important risk factor for vascular calcification in patients with chronic kidney disease. It has been found that under high phosphorus conditions, microRNA(miRNA)plays a role in regulating vascular calcification by negatively regulating the expression of target cells after transcription to promote or inhibit calcification factors. Therefore, identifying the abnormal production of miRNA under hyperphosphatemia is helpful to identify epigenetic changes, which can be used as a target for the prevention and treatment of hyperphosphatemia induced vascular calcification. In this review, miRNA and their mechanisms related to high phosphate induced vascular calcification are reviewed.
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    Journal of Hebei Medical College for Continuing Education    2023, 40 (4): 67-74.   DOI: 10.3969/j.issn.1674-490X.2023.04.011
    Abstract163)      PDF(pc) (796KB)(87)       Save
    Objective To summarize and analyze the application of transitional caring in discharged patients with diabetic foot. Methods According to methodology framework. PubMed, Cochrane Library, CINAHL, Web of Science, Embase, CNKI, Wanfang, VIP, and CBM databases were searched until December 5, 2022. To sum up and analyze the included literature. Results A total of 1934 articles were screened, and 21 articles were finally included. The main forms of transitional nursing include telephone follow-up, home follow-up, outpatient follow-up and Internet-based follow-up. The content covers self-management guidance, disease knowledge and skills guidance, psychological support, peer support, contact with medical staff. The main outcome types were health clinical outcome, health economic outcome, patient satisfaction and psychological status. Conclusion Transitional nursing plays an active role in the discharge of patients with diabetic foot. In future studies, intervention programs should be constructed based on patient needs and theoretical framework, the division of labor and authority of team members should be clarified when multidisciplinary teams would be established, the hospital-community-family linkage nursing mode should be advocated, and the training of nurses specialized in diabetic foot wound should be increased to provide support for the out-of-hospital health management of Chinese diabetic foot patients.
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    The application of formative evaluation and case-based learning in practice teaching of laboratory medicine technology
    WANG Dongping,WU Yang,WEI Lianhua,YAN Li,LI Keke,YE Hua,LI Shaohua,SUN Yanqing
    Journal of Hebei Medical College for Continuing Education    2022, 39 (4): 66-72.   DOI: 10.3969/j.issn.1674-490X.2022.04.010
    Abstract161)      PDF(pc) (536KB)(83)       Save
    Objective To explore the practice and effect of the combined application of formative evaluation and case-based learning(CBL)in the clinical education of laboratory medicine technology. Methods A total of 135 laboratory interns were randomly divided into three groups(group A, group B and group C). Group A:summative evaluation+lecture-based learning. group B: summative evaluation+ CBL. group C: formative evaluation+CBL. The teaching quality of the three groups was evaluated from two aspects of teaching content assessment and teaching effect questionnaire survey. Results The total score and theoretical score in group B and group C were higher than those in group A, and the difference was statistically significant(P<0.05).Conclusion The combination of formative evaluation and CBL can stimulate their interest in learning,cultivate students' ability to think and solve problems independently, increase teaching flexibility, arouse students' enthusiasm for learning,improve the teaching quality, and is suitable for clinical teaching.
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